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Spinal cord regeneration with infusion of ch-ABC and transplantation of bone marrow stem cells

Research Project

Project/Area Number 19591718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

MATSUYAMA Yukihiro  Nagoya University, 大学院・医学系研究科, 准教授 (20312316)

Co-Investigator(Kenkyū-buntansha) SAKAI Yoshihito  名古屋大学, 大学院・医学系研究科, 特任講師 (70378107)
ITO Zenya  名古屋大学, 医学部附属病院, 医員 (50447819)
IMAGAMA Shiro  名古屋大学, 医学部・附属病院, 医員 (40467288)
KATAYAMA Ryouji  名古屋大学, 医学部・附属病院, 医員 (40378104)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脊髄再生 / SSEP / MEP / コンドロイチナーゼABC / 骨髄間質細胞 / Nucleofection / 遺伝子導入 / 神経再生
Research Abstract

コンドロイチナーゼABCの脊髄損傷後の運動、知覚機能不全の改善作用につき明らかにすることを目的として研究を行った。脊髄損傷後における、脊髄再生において、コンドロイチナーゼABC0.05U/200Lが運動機能回復に置いて至適投与量であった。またこの酵素は脊髄損傷後に発症する痛みにも効果を認める事ができた。現在椎間板ヘルニアにたいしての臨床応用が可能となってきており、脊髄損傷患者にいち早く臨床応用可能と考えている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (22 results)

All 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (7 results)

  • [Journal Article] Surgical Results and Related Factors for Ossification of Posterior Longitsudinal Ligament of the Thorachic Spine2008

    • Author(s)
      Morio Matsumoto, Kazuhiro Chiba,Yukihiro Matsuyama
    • Journal Title

      Multi Institutional Retrospective Study 33

      Pages: 1034-1041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Muscle Relaxant on the Paraspinal Muscle Blood Flow2008

    • Author(s)
      Yoshihito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Ktayama, Shiro Imagama, Zenya Ito, Akira Okamoto
    • Journal Title

      33

      Pages: 581-587

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Segmental pedicle screwing for idiopathic scoliosis using computer-assisted surgery2008

    • Author(s)
      Yoshito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro
    • Journal Title

      J Spinal Disord Tech 21

      Pages: 181-186

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and Radiographic Outcomes of Posterolateral Lumbar Spine Fusion in Humans using Recombinant Human Bone Morphogenetic Protein-2 An Average Five-Year Follow-up Study2008

    • Author(s)
      Yoshito Katayama, Yukihiro Matsuyama, Hisatake Yoshihara, Yoshihito Sakai,Hiroshi Nakamura,Shiro Imagama,Zenya Ito,Norimitsu Wakao,Mitsuhiro Kamiya,YasutsuguYukawa, Tokumi Kanemura, Koji Sato, Hisashi Iwata, Naoki Ishiguro
    • Journal Title

      International Orthopaedics (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic predictictors for the development of myelopathy in patients with ossification of the posterior longitudinal2008

    • Author(s)
      Shunji Matsunaga,Kozo Nakamura,Atsushi Seich, Yukihiro Matsuyama
    • Journal Title

      ligament-A multicenter cohort study 33

      Pages: 2648-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chondrotinase ABC enhances axonal regeneration across nerve gaps2008

    • Author(s)
      Tatsuya Hattori, Yukihiro Matsuyama, Yoshihito Sakai, Naoki Ishiguro, Hitoshi Hirata, Ryogo Nakamura
    • Journal Title

      J Clin Neurosci 15

      Pages: 185-191

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative changes in spinal cord signal intensity in patients with cervical compression myelopathy : comparison between preoperative and postoperative magnetic resonance images2008

    • Author(s)
      Yasutsugu Yukawa Fumihiko Kato, Keigo Ito, Yumiko Horie,Tetsurou Hida,Masaaki Machino,ZenyaIto,YukihiroMatsuyama
    • Journal Title

      J Neurosurg 8

      Pages: 524-528

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy2008

    • Author(s)
      Keigo Ito,Yukihiro Matsuyama, Fumihiko Kato,Naoki Ishiguro
    • Journal Title

      J Spinal Disord Tech 21

      Pages: 145-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Muscle Relaxant on the Paraspinal Muscle Blood Flow2008

    • Author(s)
      Yoshihito Sakai
    • Journal Title

      Spine 33

      Pages: 581-587

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segmental pedicle screwing for idiopathic scoliosis using computer-assisted surgery2008

    • Author(s)
      Yoshihito Sakai
    • Journal Title

      J Spinal Disord Tech 21

      Pages: 181-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABC enhances axonal regeneration across nerve gaps2008

    • Author(s)
      Tatsuya Hattori
    • Journal Title

      J Clin Neurosci 15

      Pages: 185-191

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminoplasty and skip laminectomy for cervical compressive myelopathy : range of motion2007

    • Author(s)
      Yasutsugu Yukawa, Fumihiko Kato, Keigo Ito, Yumiko Horie ,Zenya Ito,Yukihiro Matsuyama
    • Journal Title

      postoperative neck pain, and surgical outcomes in a randomized prospective study 32

      Pages: 1980-1985

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 expression in ependymoma of the spinal cord2007

    • Author(s)
      Takahiro Naruse, Yukihiro Matsuyama, Naoki Ishiguro
    • Journal Title

      Journal of Neurosurgery 6

      Pages: 240-246

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Gene polymorphisms with Intervertebral Disc Degeneration and Vertebral Osteoplyte Formation2007

    • Author(s)
      Yoshihito Sakai, Yukihiro Matsuyama, Yukiharu Hasegawa, Hisatake Yoshihara, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro, Nobuyuki Hamajima
    • Journal Title

      21

      Pages: 1279-86

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] New artificial nerve conduits made with photocrosslinked hyaluronic acid for peripheral nerve regeneration2007

    • Author(s)
      Yoshihito Sakai, Yukihiro Matsuyama, Katsuya Takahashi, Tomoya Sato, Tatsuya Hattori, Shojiro Nakashima, Naoki Ishiguro
    • Journal Title

      Bio-Medical Materials and Engineering 17

      Pages: 191-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 側彎症手術の術中脊髄モニタリングの実態 : 脊椎脊髄病学会モニタリング委員会による多施設調査2008

    • Author(s)
      松山幸弘
    • Organizer
      日本側弯症学会
    • Place of Presentation
      奈良
    • Related Report
      2008 Final Research Report
  • [Presentation] 脊髄モニタリング中にいつ術者にアラームすべきか2008

    • Author(s)
      伊藤全哉
    • Organizer
      日本側弯症学会
    • Place of Presentation
      奈良
    • Related Report
      2008 Final Research Report
  • [Presentation] 脊椎ナビゲーション手術においてsurface matichingは必要か2008

    • Author(s)
      酒井義人
    • Organizer
      日本脊椎インストゥルメンテーション学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 自家腸骨移植と局所骨移植で後方経路腰椎椎体間固定術(PLIF)の椎体間骨癒合に差はあるか2008

    • Author(s)
      伊藤全哉
    • Organizer
      同一施設による自家腸骨と局所骨の比較検討、日本脊椎インストゥルメンテーション学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Keratan sulfate is associated with functional disturbance after spinal cord injury2008

    • Author(s)
      Zenya Ito, Kenji Kadomatsu, Yukihiro Matsuyama, Naoki Ishiguro
    • Organizer
      Annual Meeting of the Orthopaedic ResearchSociety
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Back exercise for the management of flexion and extension-provoked low back pain2007

    • Author(s)
      Yoshihito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro
    • Organizer
      International Society for the Study of the Lumbar Spine Annual Meeting
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Final Research Report
  • [Presentation] What is the risk factor worsening low back pain2007

    • Author(s)
      Zenya Ito, Yukihiro Matsuyama, Yoshihito Sakai, Hiroshi Nakamura, Shiro Imagama, Noaki Ishiguro, Hasegawa Yukiharu
    • Organizer
      A longitudinal study in a year, International Society for the Study of the Lumbar Spine Annual Meeting
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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