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Link between estrogen and TGF-beta signaling in intervertebral disc metabolism - possible therapeutic target for degenerative disc disease

Research Project

Project/Area Number 19591734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

CHIBA Kazuhiro  Keio University, 医学部, 准教授 (80179952)

Co-Investigator(Kenkyū-buntansha) TAKAISHI Hironari  慶應義塾大学, 医学部, 助教 (60236180)
TSUJI Takashi  慶應義塾大学, 医学部, 助教 (60296639)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsエストロゲン / 椎間板 / 軟骨 / 2型コラーゲン / TGF-β / MAPK / 腰痛 / 椎間板変性 / 骨粗鬆症 / Smad
Research Abstract

軟骨細胞において、エストロゲンはエストロゲン受容体α(ERα)依存性にTGF-β下流のp38MAPキナーゼシグナルと相乗的に作用することで、II型コラーゲン遺伝子発現を誘導することが明らかになった。卵巣摘出モデルおよびERα欠損マウスの表現型から、リガンド結合型ERαは椎体軟骨終板および椎間板基質の恒常性維持に寄与していることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (15 results)

  • [Journal Article] Novel apatite fiber scaffolds can promote three-dimensional proliferation of osteoblasts in rodent bone regeneration models2009

    • Author(s)
      Morisue H, Matsumoto M, Chiba K, Matsumoto H, Toyama Y, Aizawa M, Kanzawa N, Fujimi TJ, Uchida H, Okada I
    • Journal Title

      J Biomed Mater Res A. Epub ahead of print

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel apatite fiber scaffolds can promote three-dimensional proliferation of osteoblasts in rodent bone regeneration models.2009

    • Author(s)
      Morisue H, Matsumoto M, Chiba K, Matsumoto H, Toyama Y, Aizawa M, Kanzawa N, Fujimi TJ, Uchida H, Okada I.
    • Journal Title

      J Biomed Mater Res A. (Epub ahead of print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor-A is a survival for nucleus pulposus cells in the intervertebral disc2008

    • Author(s)
      Fujita N, Chiba K
    • Journal Title

      Biochem Biophys Res Commun 372巻

      Pages: 367-372

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation2008

    • Author(s)
      Hirose Y, Chiba K
    • Journal Title

      Am J Hum Genet 82巻

      Pages: 1122-1129

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale : Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association, Japan2008

    • Author(s)
      Fukui M, Chiba K
    • Journal Title

      J Orthop Sci 13巻

      Pages: 173-179

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical results and related factors for ossification of posterior longitudinal ligament of the thoratic spine : a multi-institutional retrospective study2008

    • Author(s)
      Matsumoto M, Chiba K
    • Journal Title

      Spine 33巻

      Pages: 1034-1041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for closure of lamina after open-door laminoplasty2008

    • Author(s)
      Matsumoto M, Chiba K
    • Journal Title

      J Neurosurg Spine 9巻

      Pages: 530-537

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A compound heterozygote of novel and recurrent DTDST mutations results in a novel intermediate phenotype of Desbuquois dysplasia, diastrophic dysplasia, and recessive form of multiple epiphyseal dysplasia2008

    • Author(s)
      Miyake A, Nishimura G, Futami T, Ohashi H, Chiba K, Toyama Y, Furuichi T, Ikegawa S
    • Journal Title

      J Hum Genet

      Pages: 367-372

    • NAID

      10021929219

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical treatment of intramedullary spinal cord tumors : prognosis and complications2008

    • Author(s)
      Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K
    • Journal Title

      Spinal Cord 46巻

      Pages: 282-286

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor-A is a survival for nucleus pulposus cells in the intervertebral disc.2008

    • Author(s)
      Fujita N, Chiba K
    • Journal Title

      Biochem Biophys Res Commun 372

      Pages: 367-372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.2008

    • Author(s)
      Hirose Y, Chiba K
    • Journal Title

      Am J Hum Genet 82

      Pages: 1122-1129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale : Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association, Japan.2008

    • Author(s)
      Fukui M, Chiba K
    • Journal Title

      J Orthop Sci 13

      Pages: 173-179

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical results and related factors for ossification of posterior longitudinal ligament of the thoratic spine : a multi-institutional retros pective study.2008

    • Author(s)
      Matsumoto M, Chiba K
    • Journal Title

      Spine 33

      Pages: 1034-1041

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for closure of lamina after open-door laminoplasty.2008

    • Author(s)
      Matsumoto M, Chiba K
    • Journal Title

      J Neurosurg Spine 9

      Pages: 530-537

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A compound heterozygote of novel and recurrent DTDST mutations results in a novel intermediate phenotvpe of Desbuquois dysplasia, diastrophic dysplasia, and recessive form of multiple epiphyseal dysplasia.2008

    • Author(s)
      Miyake A, Nishimura G, Futami T, Ohashi H, Chiba K, Toyama Y, Furuichi T, Ikegawa s.
    • Journal Title

      J Hum Genet

      Pages: 367-372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical treatment of intramedullary spinal cord tumors : prognosis and complications.2008

    • Author(s)
      Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K.
    • Journal Title

      Spinal Cord. 46

      Pages: 282-286

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Possible Link between Estrogen and TGF-β Signaling in Intervertebral Disc Metabolism : Estrogen receptor α-Dependent Regulation of Type II Collagen Gene Expression in Chondrocytic Cells2009

    • Author(s)
      加藤雅敬, 高石官成, 千葉一裕
    • Organizer
      55^<th> Annual Meeting of Orthopaedic Researh Society
    • Place of Presentation
      アメリカ(ラスベガス)
    • Year and Date
      2009-02-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] A possible link betwee n estrogen and TGF-β signaling in intervert ebral disc metabolism : Estrogen receptor-alp ha-dependent regulation of type II collagen gene expression in chondrocytic cells2009

    • Author(s)
      Kato, M., et al.
    • Organizer
      55^<th> Annual Meeting of Orthopaedic Researh Society
    • Place of Presentation
      Sands Expo Convention Center NV USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣摘出ラットにおける椎間板変性機序の解析(第2報)ERαを介したII型コラーゲン遺伝子の転写制御について2008

    • Author(s)
      加藤雅敬(KATO MASANORI)
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣摘出ラットにおける椎間板変性機序の解析-第2報 : ERαを介しかII型コラーゲン遺伝子の転写制御について-2008

    • Author(s)
      加藤雅敬, 高石官成, 千葉一裕
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Estorgen Regulates Type II Collagen Gene Expression via ERalpha-dependent Genomic Actions in Rat Intervertebral Disc Cells2008

    • Author(s)
      Kato, M., et al.
    • Organizer
      第23回日本整形外科学会基礎学術集会2008年国際腰椎学会
    • Place of Presentation
      Geneva Switzerland
    • Year and Date
      2008-05-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Estorgen Regulates Type II Collagen Gene Expression via ERalpha-dependent Genomic Actions in Rat Intervertebral Disc Cells2008

    • Author(s)
      加藤雅敬, 高石官成, 千葉一裕
    • Organizer
      第35回国際腰椎学会
    • Place of Presentation
      ジュネーブ
    • Year and Date
      2008-05-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2008

    • Author(s)
      M. Kato, H. Takaishi, K. Chiba
    • Organizer
      54^Annual Meeting of Orthopaedic Researh Society.
    • Place of Presentation
      San Francisco,CA
    • Year and Date
      2008-03-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariecto mized Rats2008

    • Author(s)
      Kato, M., et al.
    • Organizer
      54^<th> Annual Meeting of Orthopaedic Researh Soci ety
    • Place of Presentation
      San Francisco, CA USA
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット卵巣摘出モデルにおいて椎間板変性経時的に進行する2007

    • Author(s)
      加藤 雅敬, 高石 官成, 千葉 一裕
    • Organizer
      第22回日本整形外科学会に基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2007

    • Author(s)
      M. Kato, H. Takaishi, K. Chiba
    • Organizer
      6^Combined Meeting of Orthopaedic Research Society.
    • Place of Presentation
      Honolulu,HI
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Degeneration of Intervertebral Disc in Ovariectomized Rats.2007

    • Author(s)
      M. Kato, H. Takaishi, K. Chiba
    • Organizer
      29^The American Society for Bone and Mineral Research.
    • Place of Presentation
      Honolulu,HI
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Degeneration of Inte rvertebral Disc in Ovariectomized Rats2007

    • Author(s)
      Kato, M. et al.
    • Organizer
      29^<th> The American Society for Bone and Mineral Research
    • Place of Presentation
      Hawaii Convention Center, HI USA
    • Year and Date
      2007-09-17
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット卵巣摘出モデルにおいて椎間板変性は経時的に進行する2007

    • Author(s)
      加藤雅敬(KATO MASANORI)
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット卵巣摘出モデルにおいて椎間板変性は経時的に進行する2007

    • Author(s)
      加藤 雅敬, 高石 官成, 千葉 一裕
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomi zed Rats2007

    • Author(s)
      Kato, M., et al.
    • Organizer
      6^<th> Combined Meeting of Orthopaedic Research Society
    • Place of Presentation
      Hawaii Convention Center, HI USA
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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