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Synaptic mechanism in emotional nervous system under establishment of chronic pain

Research Project

Project/Area Number 19591736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

IKEDA Ryo  Jikei University School of Medicine, 医学部, 助教 (20439772)

Co-Investigator(Kenkyū-buntansha) KATO Fusao  東京慈恵会医科大学, 医学部, 教授 (20169519)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords筋 / 神経病学 / 扁桃体 / 慢性痛 / シナプス伝達 / 神経因性疼痛
Research Abstract

New modalities of synaptic plasticity distinct from acute pain occurred in the amygdala under establishment of neuropathic pain. Moreover, this potentiation was dependent on the structural changes of synapse in the amygdala. It was thought that this result became important for establishing a new treatment method to relief chronic pain.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (28 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (23 results)

  • [Journal Article] Synaptic potentiation in the central amygdala involves different mechanisms depending on pain model2009

    • Author(s)
      高橋由香里、池田亮、加藤総夫
    • Journal Title

      Pain Research 24巻

      Pages: 137-146

    • NAID

      10025639149

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic potentiation in the central amygdala involves different mechanisms depending on pain model2009

    • Author(s)
      高橋由香里、池田亮、加藤総夫
    • Journal Title

      PAIN RESEARCH 24

      Pages: 137-146

    • NAID

      10025639149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みの記憶と扁桃体シナプス可塑性2008

    • Author(s)
      加藤総夫、高橋由香里、池田亮
    • Journal Title

      Clinical Neuroscience 26巻

      Pages: 398-401

    • Related Report
      2009 Final Research Report
  • [Journal Article] 痛みの記憶と扁桃体シナプス可塑性2008

    • Author(s)
      加藤総夫, 高橋由香里, 池田亮
    • Journal Title

      Clinical Neuroscience 26

      Pages: 398-401

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 痛みモデル依存的扁桃体中心核シナプス増強機構の差異

    • Author(s)
      高橋由香里, 池田亮, 加藤総夫
    • Journal Title

      Pain Research (印刷中)

    • NAID

      10025639149

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 慢性痛における扁桃体内シナプス伝達増強機構の解明2009

    • Author(s)
      池田亮、高橋由香里、岩瀬中尾綾乃加藤総夫、丸毛啓史
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Morphofunctional evidence for consolidated synaptic potentiation in the nociceptive amygdala following neuropathic pain2009

    • Author(s)
      Takahashi Y, Nakao-Iwase A, Dong Y, Ikeda R, Shigemoto R, Kato F
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Related Report
      2009 Final Research Report
  • [Presentation] Properties of quantal excitatory events in thecentral amygdala in neuropathic rats.2009

    • Author(s)
      高橋由香里, 中尾(岩瀬)彩乃, Dong Yulin, 池田亮, 重本隆一, 加藤総夫
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Pre- and postsynaptic characteristics of the potentiated synaptic transmission in nociceptive amygdala in neuropathic rat.2009

    • Author(s)
      Takahashi Y, Hara M, Nakao-Iwase A, Ikeda R, Kato F
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Pre- and postsynaptic characteristics of the potentiated synaptic transmission in nociceptive amygdala in neuropathic rat.2009

    • Author(s)
      Takahashi Y, Hara M, Nakao-Iwase A, Ikeda R, Kato F.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences (IUPS2009).
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Morphofunctional evidence for consolidated synaptic potentiation in the nociceptive amygdala following neuropathic pain2009

    • Author(s)
      Takahashi Y, Nakao-Iwase A, Dong Y, Ikeda R, Shigemoto R, Kato F.
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience.
    • Place of Presentation
      Chicago
    • Related Report
      2009 Annual Research Report
  • [Presentation] Properties of quantal excitatory events in the central amygdala inneuropathic rats.2009

    • Author(s)
      高橋由香里, 中尾(岩瀬)彩乃, Dong Yulin, 池田亮, 重本隆一, 加藤総夫.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性痛の形成に関与する経時的扁桃体内シナプス伝達可塑的変化2008

    • Author(s)
      池田亮、高橋由香里、加藤総夫、丸毛啓史
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Ryo Ikeda Chronic pain as consolidated synaptic potentiation between networks underlying pain sensation and negative emotion2008

    • Author(s)
      Fusao Kato, Yukari Takahashi, Ayano Nakao-Iwase
    • Organizer
      Neuro 2008
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Amygdala synaptic plasticity in neuropathic pain2008

    • Author(s)
      Fusao Kato, Yukari Takahashi, Ayano Nakao-Iwase, Ryo Ikeda
    • Organizer
      The 3rd asian pain symposium
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] Biphasic potentiation of central amygdala synapse in rat neuropathic pain model.2008

    • Author(s)
      Takahashi Y, Ikeda R, Kato F
    • Organizer
      The 6th Forum of European Neuroscience
    • Place of Presentation
      Geneva
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 神経因性疼痛ラット扁桃体中心核シナプス増強のシナプス機構2008

    • Author(s)
      中尾(岩瀬)彩乃、高橋由香里、池田亮、加藤総夫
    • Organizer
      第31回日本神経科学学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 痛みの情動成分を担う脚傍核-扁桃体中心核シナプス伝達増強の分子基盤2008

    • Author(s)
      中尾(岩瀬)彩乃、高橋由香里、池田亮、加藤総夫
    • Organizer
      第30回日本疼痛学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ラット神経因性疼痛モデルにおける扁桃体中心核シナプス伝達の可塑的変化2008

    • Author(s)
      高橋由香里、中尾(岩瀬)彩乃、池田亮、加藤総夫
    • Organizer
      第30回日本疼痛学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ラット神経因性疼痛モデル扁桃体中心核シナプス伝達増強の二相性成立過程2008

    • Author(s)
      高橋由香里、岩瀬彩乃、池田亮、加藤総夫
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット神経因性疼痛モデル扁桃体中心核シナプス伝達増強に及ぼすNMDA受容体遮断の影響2008

    • Author(s)
      高橋由香里、岩瀬彩乃、池田亮、加藤総夫
    • Organizer
      第81回日本薬理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Amygdala synaptic plasticity in neuropathic pain2008

    • Author(s)
      Fusao Kato, Yukari Takahashi, Ayano Nakao-Iwase, Ryo Ikeda
    • Organizer
      The 3^<rd> asian pain symposium
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronic pain as consolidated synaptic potentiation between networks underlying pain sensation and neaative emotion2008

    • Author(s)
      Fusao Kato, Yukari Takahashi, Ayano Nakao-Iwase, Ryo Ikeda
    • Organizer
      Neuro 2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット神経因性痺痛モデル扁桃体中心核シナプス伝達増強の二相性成立過程2008

    • Author(s)
      高橋 由香里、岩瀬 彩乃、池田 亮、加藤 総夫
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 扁桃体における疼痛情報処理機構-神経因性慢性疼痛モデルを用いた電気生理学的検討-2007

    • Author(s)
      池田亮、加藤総夫、丸毛啓史
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-25
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Early establishment of synaptic potentiation in the central amygdala in the rat model of Neuropathic pain.2007

    • Author(s)
      Takahashi, Y., Ikeda, R., Kato, F.
    • Organizer
      37th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経因性疼痛ラット扁桃体中心核におけるシナプス可塑的変化形成過程2007

    • Author(s)
      高橋由香里、池田亮、井村泰子、加藤総夫
    • Organizer
      第30回日本神経科学大会、第50回日本神経化学会、第17回日本神経回路学会大会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Early establishment of synaptic potentiation in the central amygdala in the rat model of Neuropathic pain.2007

    • Author(s)
      Takahashi, Y., Ikeda, R.& Kato, F.
    • Organizer
      37th Annual meeting of the Society for Neuroscience,
    • Place of Presentation
      San Diego,USA
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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