| Project/Area Number |
19591743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
KAWAI Akira National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所及び東病院臨床開発センター, 研究員 (90252965)
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| Co-Investigator(Kenkyū-buntansha) |
KONDOU Tadashi 国立がんセンター, 研究所及び東病院臨床開発センター, プロジェクトリーダー (30284061)
ICHIKAWA Hitoshi 国立がんセンター, 研究所及び東病院臨床開発センター, プロジェクトリーダー (30201924)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨軟部腫瘍 / バイオマーカー / 網羅的発現解析 / タンパク質 / 遺伝子 / 悪性骨軟部腫瘍 / 二次元電気泳動 |
|---|
| Research Abstract |
In the current study a number of novel prognostic factors and factors determining the biological characteristics of gastrointestinal stromal tumor (GIST), Ewing's sarcoma, and synovial sarcoma were identified. For GIST, a novel prognostic marker "pfetin" was identified on 2D-DIGE, and its usefulness was verified by performing immunostaining for samples from multiple facilities. As for Ewing's sarcoma, "nucleophosmin" was identified as a novel prognostic marker.
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