The tumor suppression effect of anti-angiogenic therapy and antibody therapy for osteosarcoma
| Project/Area Number |
19591744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
SUGIURA Hideshi Aichi Cancer Center Research Institute, 分子病態学部, 研究員 (50303615)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Osamu 愛知県がんセンター(研究所), 分子病態学部, 室長 (00142167)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨 / 軟部腫瘍学 / 骨肉腫 / 転移抑制 / LM8 / PC61 / 抗IL-2モノクローナル抗体 / 抗体療法 / CD25 / Treg / 血管新生抑制 / Angiotensin type1 / Candesartan |
|---|
| Research Abstract |
肺転移を好発するマウス骨肉腫LM8を用いて、アンギオテンシンIIによる血管収縮を抑制するAngiotensin II receptor antagonist (Candesartan (CV-11974))の抗腫瘍効果及び抗体療法として抗IL-2レセプターα (CD25)モノクローナル抗体(PC61)や抗IL-2モノクローナル抗体(S4B6)を投与した場合における抗腫瘍効果が確認された。
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Preparation of fully activated dendritic cells capable of priming tumor-specific cytotoxic T lymphocytes in patients with metastatic cancer using penicillin-killed streptococcus pyogenes (OK432) and anti-CD40 antibody2007
Author(s)
Kontani K, Teramoto K, Ozaki Y, Sawai S, Tezuka N, Ishida H, Kajino K, Fujino S, Yamauchi A, Taguchi O, Kannagi R, Yokomise H, Ogasawara K
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Journal Title
Oncol Rep. 17
Pages: 895-902
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[Journal Article] Successful tumor eradication was achieved by collaboration of augmented cytotoxic activity and anti-angiogenic effects following therapeutic vaccines containing helper-activating analog-loaded dendritic cells and tumor antigen DNA2007
Author(s)
Teramoto, K, Kontani, K, Fujita, T, Ozaki, Y, Sawai, S, Tezuka, N, Fujino, S, Itoh, Y, Taguchi, O, Kannagi, R, Ogasawara, K
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Journal Title
Cancer Immunol. Immunother 56
Pages: 331-342
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[Presentation] 全国骨・軟部腫瘍登録電子化の歩みと今後の展望2008
Author(s)
川井章, 上田孝文, 平賀博明, 生越章, 石井猛, 杉浦英志, 松峯昭彦, 中山富貴, 下瀬省二, 田仲和宏, 横山良平
Organizer
第81回日本整形外科学会学術総会
Place of Presentation
札幌
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