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Molecular analysis of the mechanisms for articular cartilage degeneration induced by metabolic syndrome

Research Project

Project/Area Number 19591754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KOTO Tsuyoshi  Tokyo Medical and Dental University, 医学部附属病院, 助教 (80447490)

Co-Investigator(Kenkyū-buntansha) ASO Yoshinori  東京医科歯科大学, 医歯学総合研究科, 寄附講座講師 (50345279)
下地 尚  (財)癌研究会, ゲノムセンター遺伝子発現解析部門, 研究員 (40370150)
竹田 秀  東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30376727)
四宮 謙一  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20111594)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsob / obマウス / 高脂肪食 / 網羅的解析 / 変形性関節症 / 脂質代謝 / 糖代謝
Research Abstract

Leptin deficiency apparently affected articular chondrocyte metabolism independent of the effect of mechanical stress alteration or sympathetic nerve regulation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Leptin regulation of articular chondrocyte is independent of mechanical stress or sympathetic nerve stimuraltion2009

    • Author(s)
      T. Kato, H. OCHI, S. Takeda, K. Tsuji, D. Koga, Y. Hara, M. Tagawa, K. Shinomiya, Y. Asou
    • Organizer
      米国骨代謝学会
    • Related Report
      2009 Final Research Report
  • [Presentation] Leptin regulation of articular chondrocyte is independent of mechanical stress or sympathetic nerve stimuraltion.2009

    • Author(s)
      加藤剛、麻生義則, ほか
    • Organizer
      米国骨代謝学会
    • Place of Presentation
      米国・デソバー
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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