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Development of functional imaging in joint abnormalities for sensitive assessment of drug efficacy

Research Project

Project/Area Number 19591757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

NISHII Takashi  Osaka University, 医学系研究科, 寄附講座准教授 (70304061)

Co-Investigator(Kenkyū-buntansha) KURODA Kagayaki  東海大学, 情報理工学部, 准教授 (70205243)
SUGANO Nobuhiko  大阪大学, 医学系研究科, 教授 (70273620)
TANAKA Hisashi  大阪大学, 医学系研究科, 講師 (40294087)
SATO Yoshinobu  大阪大学, 医学系研究科, 准教授 (70243219)
SAKAI Takashi  大阪大学, 医学部附属病院, 助教 (00444539)
MATSUOKA Yuichirou  先端医療振興財団, 分子イメージング研究グループ, 研究員 (80372150)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords関節病学 / 変形性関節症 / MRI / T2 mapping / 関節軟骨 / 機能的イメージング
Research Abstract

To allow sensitive evaluation of early cartilage abnormalities in the hip or knee joints, we developed quantitative MR imaging system under in-situ loading system. By experimental and clinical studies, cartilage T2 mapping by loading was indicated as a promising index for evaluating early cartilage abnormalities and abnormal biomechanical conditions around the articular cartilage.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (18 results)

  • [Journal Article] Loading in situ MRIを用いた股関節T2マッピング2009

    • Author(s)
      西井孝, 塩見俊行, 坂井孝司, 高尾正樹, 中原一郎, 津田晃佑, 吉川秀樹, 菅野伸彦
    • Journal Title

      Hip Joint 35

      Pages: 635-638

    • NAID

      10026119855

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loading and knee-alignment have significant influence on cartilage T2 in porcine knee joints2009

    • Author(s)
      Toshiyuki Shiomi, et al.
    • Journal Title

      Osteoarthritis Cartilage 17 supple

      Pages: 204-204

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loading in situ MRIを肺いた股関節T2マッピング2009

    • Author(s)
      西井孝, ほか
    • Journal Title

      Hip Joint 35

      Pages: 635-638

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 関節軟骨のT2マッピングによる臨床研究2009

    • Author(s)
      西井 孝, ほか
    • Journal Title

      ルーチンクリニカル 40

      Pages: 90-96

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia.2008

    • Author(s)
      Nishii T, Tanaka H, Sugano N, Sakai T, Hananouchi T, Yoshikawa H.
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 227-33

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change in knee cartilage T2 in response to mechanical loading.2008

    • Author(s)
      Nishii T, Kuroda K, Matsuoka Y, Sahara T, Yoshikawa H.
    • Journal Title

      J Magn Reson Imaging 28

      Pages: 175-80

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia.2008

    • Author(s)
      Takashi Nishii, et al
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 227-233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in knee cartilage T2 in response to mechanical loading2008

    • Author(s)
      Takashi Nishii, et al
    • Journal Title

      J Magn Reson Imaging 28

      Pages: 175-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パラメトリックマッピングによる関節軟骨の定量評価 -T2マッピングを中心に2008

    • Author(s)
      西井 孝, ほか
    • Journal Title

      INNERVISION 23

      Pages: 17-20

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia.2008

    • Author(s)
      Takashi Nishii
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 227-233

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T2緩和時間による股関節MRIの関節軟骨質的評価2007

    • Author(s)
      西井孝, 菅野伸彦, 坂井孝司, 花之内健仁, 吉川秀樹
    • Journal Title

      Hip Joint 33

      Pages: 163-166

    • NAID

      10019754557

    • Related Report
      2009 Final Research Report
  • [Journal Article] Disorders of acetabular labrum and articular cartilage in hip dysplasia: evaluation using isotropic high-resolutional CT arthrography with sequential radial reformation.2007

    • Author(s)
      Takashi Nishii
    • Journal Title

      Osteoarthritis Cartilage 15

      Pages: 251-257

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 変形性股関節症における軟骨変性の画像評価2007

    • Author(s)
      西井 孝
    • Journal Title

      関節外科 26

      Pages: 12-19

    • Related Report
      2007 Annual Research Report
  • [Journal Article] T2緩和時間による股関節MRIの関節軟骨質的評価2007

    • Author(s)
      西井 孝
    • Journal Title

      Hip Joint 33

      Pages: 163-166

    • NAID

      10019754557

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Influence of Knee Positions on T2, T2*, and dGEMRIC Mapping in Porcine Knee Cartilage.

    • Author(s)
      Shiomi T, Nishii T, Myoui A, Yoshikawa H, Sugano N.
    • Journal Title

      Magn Reson Imaging (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loaded Cartilage T2 Mapping in Patients with Hip Dysplasia.

    • Author(s)
      Nishii T, Shiomi T, Tanaka H, Yamazaki Y, Murase K, Sugano N.
    • Journal Title

      Radiology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 荷重下の関節軟骨MRI評価2009

    • Author(s)
      西井孝, 塩見俊行, 坂井孝司, 高尾正樹, 田中壽, 吉川秀樹, 菅野伸彦
    • Organizer
      第14回日本関節症研究会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Evaluation of Cartilage T2 Using Loading in situ MRI in Early Osteoarthritis with Hip Dysplasia.2009

    • Author(s)
      Nishii T., Shiomi T., Tanaka H., Murase K., Yamazaki Y., Sakai T., Takao M., Yoshikawa H, Sugano N.
    • Organizer
      ISMRM 17th Scientific Meeting & Exhibition
    • Place of Presentation
      Honolulu
    • Related Report
      2009 Final Research Report
  • [Presentation] Cartilage T2 mapping in hip dysplasia using loading in situ MRI.2009

    • Author(s)
      Nishii T; Shiomi T; Tanaka H; Murase K; Sakai T; Takao M; Yoshikawa H; Sugano N.
    • Organizer
      The 55rd Annual Meeting, Orthopaedic Research Society
    • Place of Presentation
      Las Vegas
    • Related Report
      2009 Final Research Report
  • [Presentation] Cartilage T2 mapping in hip dysplasia using loading in situ MRI2009

    • Author(s)
      西井孝, et al
    • Organizer
      The 55rd Annual Meeting, Orthopaedic Research Society
    • Place of Presentation
      Las Vegas,USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of Cartilage T2 Using Loading in situ MRI in Early Osteoarthritis with Hip Dysplasia2009

    • Author(s)
      西井孝, et al
    • Organizer
      ISMRM 17th Scientific Meeting & Exhibition
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膝関節障害例における荷重下MRIを用いた関節軟骨の差分T2 mapping2009

    • Author(s)
      西井孝, ほか
    • Organizer
      第37回日本磁気共鳴医学学会大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 荷重下MRIを用いた関節軟骨の差分T2 mapping -臼蓋形成不全例への応用2009

    • Author(s)
      西井孝, ほか
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cartilage T2 Mapping Using Loading in situ MRI in Early Osteoarthritis with Hip Dysplasia2009

    • Author(s)
      Takashi Nishii, et al
    • Organizer
      ISMRM Musculoskeletal Workshop
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Annual Research Report
  • [Presentation] MRIによる関節症進行と治療効果の予見性について2008

    • Author(s)
      西井孝, 吉川秀樹, 坂井孝司, 高尾正樹, 菅野伸彦
    • Organizer
      第23回日本臨床リウマチ学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 下肢圧迫デバイスを用いた荷重下股関節T2マッピング2008

    • Author(s)
      西井孝, 吉川秀樹, 坂井孝司, 高尾正樹, 菅野伸彦
    • Organizer
      第36回日本磁気共鳴医学学会大会
    • Place of Presentation
      旭川
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Loading in situ MRI を用いた股関節T2マッピング2008

    • Author(s)
      西井 孝, ほか
    • Organizer
      第35回日本股関節学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cartilage T2 relaxation time under loading condition in patients with normal and injured knee joints.2007

    • Author(s)
      Nishii T., Kuroda K., Matsuoka Y., Nakata K., Yoshikawa H.
    • Organizer
      2007World Congress on Osteoarthritis
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2009 Final Research Report
  • [Presentation] Cartilage T2 relaxation time under loading condition in patients with normal and injured knee joints2007

    • Author(s)
      Takashi Nishii
    • Organizer
      2007 World Congress on Osteoarthritis
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2007 Annual Research Report
  • [Presentation] Assessment of knee change T2 in response to mechanical loading at 3.0 T MR imaging2007

    • Author(s)
      Takashi Nishii
    • Organizer
      Workshop on Imaging-based Measures of Osteoarthritis
    • Place of Presentation
      Salzburg
    • Related Report
      2007 Annual Research Report
  • [Presentation] Change in knee cartilage T2 in response to mechanical loading at 3.0 T2007

    • Author(s)
      Takashi Nishii
    • Organizer
      Joint Annual Meeting ISMRM・ESMRMB
    • Place of Presentation
      Berlin
    • Related Report
      2007 Annual Research Report
  • [Presentation] 下肢圧迫デバイスを用いた膝関節軟骨の荷重下T2時間評価2007

    • Author(s)
      西井 孝
    • Organizer
      日本磁気共鳴医学学会大会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Presentation] 変形性関節症のMRI診断-早期病態の定性評価から定量評価へのトレンドー2007

    • Author(s)
      西井 孝
    • Organizer
      日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 3TMR装置用Wireless RF coilの開発2007

    • Author(s)
      佐原 朋広
    • Organizer
      日本磁気共鳴医学学会大会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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