| Project/Area Number |
19591759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIROSE Jun Kumamoto University, 医学部附属病院, 講師 (40433007)
|
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTA Hirosi 熊本大学, 大学院・生命科学研究部, 教授 (60174025)
ONIKI Yasunari 熊本大学, 医学部附属病院, 助教 (20423684)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
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| Keywords | 変形性関節症 / 糖尿病 / 糖化最終産物 / 糖化最終産物(AGEs) / receptor for AGEs(RAGE) / receptor for AGEs (RAGE) |
|---|
| Research Abstract |
To clarify the molecular based relationship of osteoarthritis (OA) and diabetes mellitus (DM), we evaluated accumulations of advanced glycation end products (AGEs) in joint tissues. DM rats showed similar AGE accumulations and the expression of mRNA and proteins related with OA on both cartilage and synovium compared with normal rats. There was also no difference of AGE accumulations among cultured chondrocytes treated with various concentrations of glucose. Moreover, susceptibility of OA induced by knee ligament resection was similar between DM and normal rats. These results indicate indistinguishable associations with OA and DM from the point of view of AGEs.
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