| Project/Area Number |
19591772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
TANAKA Shinya University of Occupational and Environmental Health, Japan, 医学部, 講師 (20412645)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中村 利孝 産業医科大学, 医学部, 教授 (50082235)
酒井 昭典 産業医科大学, 医学部, 准教授 (90248576)
大西 英生 産業医科大学, 医学部, 講師 (20279342)
内田 宗志 産業医科大学, 医学部, 助教 (60330990)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 高脂血症 / 高脂質食 |
|---|
| Research Abstract |
The high-fat diet increases neuropeptideY mRNA expression in the hypothalamus and peripheral dopaminergic neuron activity and which results in decreases of the cancellous bone and the osteoblastic bone formation and increases in osteoclastic bone resorption in ovariectomized mice in relation with the increased expression of noggin and rankl mRNA in the bone marrow adherent cells.
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