Estimation of intra-blood substance concentration using evanescent wave fluorescence

• Project/Area Number: 19591785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: DOL Matsuyuki Hamamatsu University School of Medicine, 医学部附属病院, 講師 (10155616)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Seiji 浜松医科大学, 光量子医学研究センター, 准教授 (60144094) ; MIYAKAWA Atsuo 静岡大学, 工学部, 学術研究員 (10283376)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 光テクノロジー / 血管内カテーテル / 血中濃度測定

Research Abstract

(1)エバネッセント蛍光測定法に適した血液内物質を検索し,プロポフォール,リボフラビン,インドシアニングリーンの蛍光を検出した。
(2)エバネッセント蛍光測定用血管内カテーテルのプロトタイプモデルを試作した。リボフラビン水溶液にて530nmの蛍光が発生していることを観察できたが,コアから蛍光を検出することはできなかった。蛍光強度が微弱であるので,モデルの改良と検出器の感度増強が必要との結論に達した。

Research Products

• [Journal Article] Evanescent wave catheter: new phototechnology in anaesthesia and intensive care. (2007)
  • Author(s): Matsuyuki Doi
  • Journal Title: Journal of Clinical Monitoring and Computing 21 Pages: 177-179
  • Peer Reviewed
• [Presentation] Estimation of intra-blood substance concentrations using clinical fibre-optic catheter. (2007)
  • Author(s): Matsuyuki Doi
  • Organizer: 15th ASEAN Congress of Anesthesiologists
  • Place of Presentation: Thiland
  • Year and Date: 2007-11-13
• [Presentation] Estimation of intra-blood substance concentrations using clinical fibre-optic catheter. (2007)
  • Author(s): Matsuyuki Doi
  • Organizer: Advance in anaesthesia and intensive care
  • Place of Presentation: Glasgow, United Kingdom
  • Year and Date: 2007-09-07
• [Presentation] Estimation of infra-blood substance concentrations using clinical fibre-optic catheter (2007)
  • Author(s): Matsuyuki Doi
  • Organizer: Advance in anaesthesia and intensive care
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2007-09-07