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The searching a mechanism of general anesthesia modulated by non-synaptic communication of nitric oxide in the brain

Research Project

Project/Area Number 19591787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

ADACHI Yushi  Hamamatsu University School of Medicine, 医学部附属病院, 助教 (80420355)

Co-Investigator(Kenkyū-buntansha) SATO Shigehito  浜松医科大学, 医学部, 教授 (30143176)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords麻酔学 / 一酸化窒素 / 麻酔薬 / ペントバルビタール / ケタミン / マイクロダイアリシス法 / ニトログリセリン / ニトロプルシド
Research Abstract

全身麻酔は日常臨床の場において広く用いられているにも関わらず、その麻酔作用発揮のメカニズムは未知のままである。我々は、近年注目されている神経伝達物質である一酸化窒素と、その非シナプス型神経伝達に注目し、麻酔薬の作用機序解明を目指した。これまでに、麻酔薬が非シナプス型神経伝達をも抑制し、他の神経伝達物質の制御にも関わっている事を発見した。

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Book (1 results)

  • [Journal Article] 佐藤重仁アミトリプチリンとパロキセチンでともにセロトニン症候群が生じたと考えられた1例2009

    • Author(s)
      足立裕史, 山口昌一, 中島芳樹, 五十嵐寛
    • Journal Title

      日本ペインクリニック学会誌 16

      Pages: 23-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isoflurane anesthesia inhibits clozapine-and risperidone-induced dopamine release and anesthesia-induced changes in dopamine metabolism was modified by fluoxetine in the rat striatum: an in vivo microdialysis study.2009

    • Author(s)
      Adachi YU, Yamada S, Satomoto M, Higuchi H, Watanabe K, Kazama T, Mimuro S, Sato S.
    • Journal Title

      Eur J Anaesthesiol 26,45

      Pages: 100-1

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nafamostat prevents hypothermia and improves survival time after administration of lipopolysaccharide in a mouse surgical model2009

    • Author(s)
      Adachi YU, Obata Y, Suzuki K, Katoh H, Itagaki T, Doi M, Sato S.
    • Journal Title

      J Anesth 23

      Pages: 624-7

    • NAID

      10027265316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nafamostat prevents hypothermia and improves survival time after administration of lipopolysaccharide.2008

    • Author(s)
      Adachi YU, Obata Y, Suzuki K, Katoh H, ItagakiT, Doi M, Sato S.
    • Journal Title

      J Anesth 23

      Pages: 624-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pentobarbital-induced reduction of nitric oxide in the rat brain striatum was antagonized by nicotine and NMDA.2008

    • Author(s)
      Adachi YU, Itagaki T, Obata Y, Shiraishi Y, Sato S.
    • Journal Title

      Eur J Anaesthesiol 25,44

      Pages: 129-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Propofol-induced reduction of nitric oxide in rat brain was antagonized by neostigmine and arginine.2008

    • Author(s)
      Adachi YU, Kimura K, Mimuro S, Doi M, Sato S.
    • Journal Title

      Anesthesiology 109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isofurane anesthesia inhibits clozapine-and risperidone・induced dopamine release and anesthesia-induced changes in dopamine metabolism was modified by fluoxetine in the rat striatum:an in vivo microdialysis study2008

    • Author(s)
      Adachi YU, Yamada S, Satomoto M, et. al.
    • Journal Title

      Neurochemistry International 52

      Pages: 384-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ketamine Increased Nitric Oxide Release in the Rat Striatum Independent from Acetylcholine Release.2007

    • Author(s)
      Adachi YU, Mimuro S, Uraoka M, Shiraishi Y, Sato S.
    • Journal Title

      Anesthesiology 107

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pentobarbital inhibits the release of nitric oxide and the effect is antagonized by the application of neostigmine and magnesium-free perfusion in the rat striatum: an in vivo microdialysis study.2007

    • Author(s)
      Adachi YU, Mimuro S, Doi M, Sato S.
    • Journal Title

      Eur J Anaesthesiol 24,39

      Pages: 82-3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] The nitroglycerine-induced nitric oxide release was enhanced by propoofl in rats striatum-in vivo microdialysis study2009

    • Author(s)
      Adachi YU, Kimura K, Mimuro S, Doi M, Sato S.
    • Organizer
      Eur J Anaesthesiol 2009 ; 26 Supple 45:100 (7AP3-6)
    • Place of Presentation
      Milan, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adachi YU, Kimura K, Mimuro S, Doi M, Sato S. The release of nitricoxide was anhanced by GABAergic inhibition and NMDAergic potentiation and the both effects were antagonized by propofol and sevoflurane anesthesia in rats striatum2009

    • Author(s)
      Adachi YU, Kimura K, Mimuro S, Doi M, Sato S.
    • Organizer
      Eur J Anaesthesiol 2009 ; 26 Supple 45:100 (7AP3-6)
    • Place of Presentation
      Milan, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Nitroglycerine-Induced Nitric Oxide Release Was Enhanced by Propofol Not by Sevoflurane in Rats2009

    • Author(s)
      Adachi YU, Kimura K, Mimuro S, Itagaki T, Sato S.
    • Organizer
      American society of Anesthesiologists, Annual Meeting 2009
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Propofol-induced reduction of nitric oxide in rat brain was antagonized by neostigmine and arginine.2008

    • Author(s)
      Adachi YU, Kimura K, Mimuro S, Doi M, Sato S.
    • Organizer
      American Society of Anesthesiologists, Annual Meeting
    • Place of Presentation
      Orlando Florida
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] ぺンドバルビタールによるラツト脳線条体-酸化窒素放出抑制作用はニコンおよびNMDAによって拮抗される2008

    • Author(s)
      足立裕史
    • Organizer
      目本麻酔科学会第55回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pentobarbital-induced reduction of nitric oxide in the rat brain striatum was antagonized by nicotine and NMDA.2008

    • Author(s)
      Adachi YU, Itagaki T, Obata Y, Shiraishi Y, Sato S.
    • Organizer
      Euroanaesthesia 2008, The European Anaesthesiology Congress
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sevoflurane-induced reduction of nitric oxide in the rat brain striatum, is antagonized by nicotine and neostigmine, but not by NMDA.2008

    • Author(s)
      Itagaki T, Obata Y, Adachi YU, Shiraishi Y, Sato S.
    • Organizer
      Euroanaesthesia 2008, The European Anaesthesiology Congress
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ketamine Increased Nitric Oxide Release in the Rat Striatum Independent from Acetylcholine Release.2007

    • Author(s)
      Adachi YU, et. al.
    • Organizer
      American Society of Anesthesiologists, Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-10-13
    • Related Report
      2007 Annual Research Report
  • [Book] 土井松幸訳稲田英一監訳精神機能の異常in ICUブック(第3版メディカル・サイエンス・インターナショナル東京)2008

    • Author(s)
      足立裕史
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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