| Project/Area Number |
19591791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Osaka University |
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Principal Investigator |
TAKASHINA Masaki Osaka University, 医学部附属病院, 講師 (30221352)
|
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| Co-Investigator(Kenkyū-buntansha) |
HAGIHIRA Satoshi 大阪大学, 医学部附属病院, 講師 (90243229)
NAKAE Aya 大阪大学, 医学部附属病院, 特任准教授 (60379170)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | セロトニン2C受容体 / RNA編集 / 神経因性疼痛モデル / 脊髄障害性モデル / 脊髄障害性疼痛 / 脊髄障害性疼痛モデル / 核小体低分子RNA / RBII-52 / SCI / 選択的スプライシング / 脊髄坐滅モデル / 神経因性疼痛 |
|---|
| Research Abstract |
We investigated the effects on 5HT2C receptor RNA editing efficiency of contusive SCI. Using cloning followed by sequence analysis on spinal cord samples takes, we compared mRNA editing. Our results might be evidence of functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn.
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