| Project/Area Number |
19591792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Osaka University |
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Principal Investigator |
MIYAMOTO Yoshikazu Osaka University, 医学系研究科, 助教 (70278844)
|
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| Co-Investigator(Kenkyū-buntansha) |
IWANE Atsuko 大阪大学, 生命機能研究科, 准教授 (30252638)
YANAGIDA Toshio 大阪大学, 生命機能研究科, 教授 (30089883)
MAHIMO Takashi 大阪大学, 医学系研究科, 教授 (10110785)
NISHIYAMA Masayoshi 京都大学, 理学研究科, 助教 (10346075)
真下 節 大阪大学, 医学系研究科, 教授 (60157188)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 揮発性麻酔薬 / 麻酔メカニズム / モーター蛋白 / キネシン / 微小管 / アクチン / ミオシン |
|---|
| Research Abstract |
By using in vitro motility assay, we determined the direct effects of inhalational anesthetics sevoflurane and isoflurane on microtubule-based kinesin motility. By applying inhalational anesthetics, most of the microtubules stopped sliding movements, and their motility almost recovered after washing out of the anesthetics.
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