Effect of pretreatment with phospholipids on acute lung injury : especially effect of cardiolipin

• Project/Area Number: 19591793
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tottori University
• Principal Investigator: MOCHIDA Shinsuke Tottori University, 医学部附属病院, 助教 (70403433)
• Co-Investigator(Kenkyū-buntansha): MATSURA Tatsuya 鳥取大学, 医学部, 教授 (00199746) ; INAGAKI Yoshimi 鳥取大学, 医学部, 教授 (40184717) ; ISHIBE Yuichi 鳥取大学, 名誉教授 (40122014)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 急性肺傷害 / カルジオリピン / リポポリサッカライド / マクロファージ / リン脂質 / サイトカイン / 一酸化窒素

Research Abstract

In the present study, we investigated whether cardiolipin (CL) suppresses acute lung injury in mice induced by lipopolysaccharide (LPS). Ithas been demonstrated that CL prevents LPS-induced acute lung injury via the inhibition of production of proinflammatory mediators such as nitric oxide and tumor necrosis factor-α.

Research Products

• [Journal Article] Polaprezinc protects mice against endotoxin shock. (2010)
  • Author(s): Ohata S, Moriyama C, Yamashita A, Nishida T, Kusumoto C, Mochida S, Minami Y, Nakada J, Shomori K, Inagaki Y, Ohta Y, Matsura T.
  • Journal Title: J. Clin. Biochem. Nutr. Vol.46(3) Pages: 234-243
  • NAID: 130004466618
  • Peer Reviewed
• [Journal Article] Polaprezinc protects mice against endotoxin shock
  • Author(s): Ohata S, 他11名
  • Journal Title: J.Clin.Biochem. Nutr. (印刷中)
  • Peer Reviewed
• [Presentation] ポラプレジンクによるLPS誘導マウスエンドトキシンショックの抑制効果 (2008)
  • Author(s): 大畑修三、松浦達也、森山千尋、山下敦、太田好次、山田一夫
  • Organizer: 第16回生体パーオキサイド研究会
  • Place of Presentation: 仙台市
  • Year and Date: 2008-08-30
• [Presentation] ポラプレジンクによるLPS誘導マウスエンドトキシンショックの抑制効果 (2008)
  • Author(s): 大畑修三
  • Organizer: 第16回生体パーオキサイド研究会
  • Place of Presentation: 仙台市、勝山館
  • Year and Date: 2008-08-30
• [Presentation] Oral administration of polaprezinc, an anti-ulcer drug, protects mice against endotoxin shock (2008)
  • Author(s): T. Matsura, C. Moriyama, A. Yamashita, H. Morikawa, T. Nishida, S. Ohata, C. Kusumoto, J. Nakada, K. Yamada
  • Organizer: 47th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Seattle
  • Year and Date: 2008-03-19
• [Presentation] Protection by polaprezinc against lipopolysaccharide-induced macrophage activation and endotoxin shock in mice (2007)
  • Author(s): C. Moriyama, T. Matsura, A. Yamashita, H. Morikawa, T. Nishida, S. Ohata, C. Kusumoto, J. Nakada, K. Yamada
  • Organizer: 第80回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-14