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The effect of bone marrow stem cell transplantation for chronic pain model in the rat

Research Project

Project/Area Number 19591796
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHiroshima University

Principal Investigator

SARADA Kazuhiro  Hiroshima University, 病院, 理学療法士 (20423353)

Co-Investigator(Kenkyū-buntansha) ITO Yoshihiro  広島大学, 病院, 理学療法士 (60397958)
KIMURA Hiroaki  広島大学, 病院, 講師 (60363074)
SHIMADA Noboru  広島大学, 病院, 理学療法士 (20467773)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsCRPS / 骨髄幹細胞移植 / 神経因性疼痛 / 慢性疼痛
Research Abstract

複合性局所疼痛症候群(Complex Regional Pain Syndrome : 以下CRPS)の実験系としてラットの疼痛過敏モデルであるChungモデルを作製した。Chungモデルを無作為に骨髄細胞移植群と対照群に分けた。骨髄細胞移植群には骨髄幹細胞を, 対象群には生理食塩水をくも膜下腔に注入した。注入後から痛覚過敏の評価を経時的に実施した。経時的な疼痛抑制効果において, 有意に骨髄幹細胞移植群で痛覚過敏の早期低下を認めた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (1 results)

All 2009

All Presentation (1 results)

  • [Presentation] Intrathecal administration of bone marrow for the treatment of neuropathic pain2009

    • Author(s)
      木村浩彰
    • Organizer
      ISPRM
    • Place of Presentation
      イスタンブール,トルコ
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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