Mechanisms of contraction/relaxation of airway smooth muscle : relationship between β-antagonist and Rho-kinase pathway

• Project/Area Number: 19591804
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: SHIBATA Osamu Nagasaki University, 病院, 准教授 (80136671)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: ラット / 気道平滑筋 / β遮断薬 / Rhoキナーゼ / Rhoキナーゼ阻害薬 / 連続性フィールド電気刺激 / ファスジル / アスジル / ベータ遮断薬 / PIレスポンス

Research Abstract

The results suggest that high concentrations of landiolol could cause airway smooth muscle contraction through the Rho-kinase pathway, but not through the PI response coupled with muscarinic M3 receptors, 5-HT receptors or the activation of L-type Ca(2+) channels.

Research Products

• [Journal Article] Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity in isolated rat trachea (2009)
  • Author(s): Matsunaga S, Shibata O, Nishioka K, Tsuda A, Makita T, Sumikawa K
  • Journal Title: J Anesth 23(3) Pages: 385-91
  • NAID: 10027264183
• [Journal Article] Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity in isolated rat trachea. (2009)
  • Author(s): Matsunaga S
  • Journal Title: J Anesth. 23 Pages: 385-91
  • Peer Reviewed
• [Journal Article] High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway (2008)
  • Author(s): Shibata O, Nishioka K, Yamaguchi M, Makita T, Sumikawa K
  • Journal Title: J Anesth 22(1) Pages: 21-6
  • NAID: 10024128507
• [Journal Article] Hyperosmolarity attenuates the contraction of rat trachea hrough the inhibition of phosphatidylinositol response (2008)
  • Author(s): Saito M, Shibata O, Tsuda A, Makita T, Sumikawa K
  • Journal Title: ActaMedicaNagasakiensia 52 Pages: 107-110
• [Journal Article] High concentrations of landiolol, a β1-adrenoceptor antagonist, stimulates smooth muscle contraction of the rat trachea through the Rho-kinase pathway (2008)
  • Author(s): Osamu Shibata
  • Journal Title: J Anesth 22 Pages: 21-26
  • Peer Reviewed
• [Presentation] ラット気管平滑筋における連続性フィールド電気刺激誘発性収縮に対するセボフルレンおよびRhoキナーゼ阻害薬ファスジルの影響 (2009)
  • Author(s): 柴田治
  • Organizer: 第56日本麻酔科学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-08-17
• [Presentation] Fasudil, a Rho-kinase inhibitor, potentiates the relaxant effect of sevoflurane on continuous electrical field stimulation-induced smooth muscle contraction of rat trachea (2009)
  • Author(s): O. Shibata, S. Matsunaga, A. Tsuda, T. Makita, K. Sumikawa
  • Organizer: Eur J Anaesthesiol
• [Presentation] ラット気管平滑筋における連続性フィールド電気刺激誘発性収縮に対するセボフルレンおよびRhoキナーゼ阻害薬ファスジルの影響 (2009)
  • Author(s): 柴田治、松永祥志、津田敦、槙田徹次、澄川耕二
  • Organizer: 日本麻酔科学会56
  • Place of Presentation: 神戸
• [Presentation] ラット気管平滑筋におけるElectrical field stimulation誘発性収縮に対するRhoキナーゼ阻害薬フアスジルの影響 (2008)
  • Author(s): 柴田 治
  • Organizer: 日本麻酔科学会第5 5回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-12
• [Presentation] ラット気管平滑筋におけるElectrical field stimulation誘発性収縮に対するRhoキナーゼ阻害薬ファスジルの影響 (2008)
  • Author(s): 柴田治、松永祥志、津田敦、槙田徹次、澄川耕二
  • Organizer: 日本麻酔科学会55
  • Place of Presentation: 横浜