Mechanisms of contraction/relaxation of airway smooth muscle : relationship between β-antagonist and Rho-kinase pathway
| Project/Area Number |
19591804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIBATA Osamu Nagasaki University, 病院, 准教授 (80136671)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ラット / 気道平滑筋 / β遮断薬 / Rhoキナーゼ / Rhoキナーゼ阻害薬 / 連続性フィールド電気刺激 / ファスジル / アスジル / ベータ遮断薬 / PIレスポンス |
|---|
| Research Abstract |
The results suggest that high concentrations of landiolol could cause airway smooth muscle contraction through the Rho-kinase pathway, but not through the PI response coupled with muscarinic M3 receptors, 5-HT receptors or the activation of L-type Ca(2+) channels.
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Report
(4 results)
Research Products
(10 results)
