Nitric oxide involving in the opiod-induced paraplegia
| Project/Area Number |
19591809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
KAKINOHANA Manabu University of the Ryukyus, 医学部, 准教授 (20274897)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Seiya 国立大学法人琉球大学, 医学部附属病院, 講師 (00363680)
SAIKAWA Satoko 国立大学法人琉球大学, 医学部附属病院, 助教 (20404569)
HIGA Tasuya 国立大学法人琉球大学, 医学部附属病院, 助教 (10404568)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 対麻痺 / 脊髄虚血 / オピオイド / 一酸化窒素 / 痙性対麻痺 / cGMP / 麻薬 / モルヒネ |
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| Research Abstract |
Our previous study showed that opioid receptor activation even after short-lasting spinal cord ischemia in the rat could cause irreversible paraplegia. This study elucidated the relationship between nitric oxide and morhine inducing paraplegia after spinal cord ischemia. While IT morphine alone could induce irreversible paraplegia, the combination between IT morphine and ODQ failed to induce neurological deficit. Our results suggested that nitric oxide-guanylate cyclase-cGMP pathway should be involved in the inducing paraplegia.
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Report
(4 results)
Research Products
(20 results)
