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The influences of various anesthetics on the circadian rhythm of melatonin.

Research Project

Project/Area Number 19591811
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYokohama City University

Principal Investigator

KIKUCHI Yatsuaki  Yokohama City University, 附属病院, 准教授 (70285138)

Co-Investigator(Kenkyū-buntansha) INAGAWA Gaku  横浜市立大学, 医学研究科, 客員准教授 (60336584)
Research Collaborator MIHARA Takahiro  横浜市立大学, 医学研究科, 大学院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords麻酔薬 / メラトニン / マイクロダイアリシス / 日内リズム / 麻酔 / 日内変動 / 松果体
Research Abstract

作用機序の異なる麻酔薬(ケタミンおよびペントバルビタール)でラットの頭部手術を行った後の松果体からのメラトニン遊離に与える影響を投与時間による差異に着目してマイクロダイアリシス法を用いて調べた。ケタミン麻酔で手術を行った場合、昼間(ラットの休息期)の手術後はメラトニン上昇の位相に変化はなかったが、夜間(ラットの活動期)の手術後は位相の前方へのシフトが見られた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Lidocaine Concentration in Cerebrospinal Fluid after Epidural Administration : A Comparison between Epidural and Combined Spinal-Epidural Anesthesia2009

    • Author(s)
      Kamiya Y, Kikuchi T, Inagawa G, Miyazaki H, Miura M, Morita S, Goto T
    • Journal Title

      Anesthesiology 110(5)

      Pages: 1127-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Randomized prospective study comparing the laryngeal tube suction II with the ProSeal laryngeal mask airway in anesthetized and paralyzed patients2008

    • Author(s)
      Kikuchi T, Kamiya Y, Ohtsuka T, Miki T, Goto T
    • Journal Title

      Anesthesiology 109(1)

      Pages: 54-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Lidocaine concentration in cerebrospinal fluid after epidural administration : A comparison between epidural and combined spinal-epidural anesthesia2009

    • Author(s)
      Kamiya Y, Kikuchi T, Inagawa G, Miyazaki H, Goto T.
    • Organizer
      Euroanesthesia 2009
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2009-06-08
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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