Importance of treatment of cerebral white matter damage following acute cerebral ischemia

• Project/Area Number: 19591825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kansai Medical University
• Principal Investigator: NAKAO Shinichi Kansai Medical University, 医学部, 准教授 (10207714)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 全脳虚血 / 脳灰白質 / 脳白質 / 神経軸索 / 海馬 / エダラボン / 活性酸素 / 神経細胞体 / ミクログリア / βAPP / 心停止 / 脳虚血 / CA1

Research Abstract

ラット5分間心肺停止モデルによる全脳虚血1 週間後に、海馬CA1に限定された神経細胞体の傷害とミクログリアの活性化が認められたが、神経軸索の傷害は見られなかった。虚血2週間後には、神経細胞体傷害の新たな広がりや重症化は認められなかったが、著明な神経軸索の傷害が認められた。これらの神経細胞体傷害と神経軸索傷害は、心肺再開60分後に投与した抗酸化薬エダラボンにより、コントロールレベルにまで抑制された。

Research Products

• [Journal Article] An unusual case of airway obstruction at the tip of an endotracheal tube caused by insertion of a nasogastric tube (2008)
  • Author(s): Kubo K, Nakao S, Kawabata Y, Nishimae H, Masuko S, Shingu K
  • Journal Title: J Anesth 22 Pages: 52-4
  • NAID: 10024128652
  • Peer Reviewed
• [Journal Article] 急性脳虚血における脳白質保護の重要性 (2008)
  • Author(s): 中尾慎一、宮本悦子、阪本幸世、上村幸子、増澤宗洋、久保古寿江、叶多知子、新宮興
  • Journal Title: 蘇生 27 Pages: 1-6
  • NAID: 10025707031
  • Peer Reviewed
• [Journal Article] 急性脳虚血における脳白質保護の重要性 (2008)
  • Author(s): 中尾 慎一
  • Journal Title: 蘇生 27 Pages: 1-6
  • NAID: 10025707031
  • Peer Reviewed
• [Journal Article] Massive prosthetic valve thrombus in a patient with idiopathic hypereosinophillic syndrome (2007)
  • Author(s): Mizota T, Miyawaki I, Enoki T, Nakao S
  • Journal Title: J Cardiothorac Vasc Anesth 21 Pages: 434-5
  • Peer Reviewed
• [Journal Article] 臨床医学の展望 (2007)
  • Author(s): 中尾慎一、新宮興
  • Journal Title: 麻酔科学 : 医事新報 4319 Pages: 28-32
• [Journal Article] Edaravone, a free radical scavenger, mitigates both gray and white matter damage after global cerebral ischemia in rats
  • Author(s): Kubo K, Nakao S, Jomura S, Sakamoto S, Miyamoto E, Xu Y, Tomimoto H, Inada T, Shingu K
  • Journal Title: Brain Res (in press)
  • Peer Reviewed
• [Presentation] ラット心肺停止・再濯流モデルにおけるエダラボンのミクロクリア活性化と神経細胞傷害に対する影響 (2009)
  • Author(s): 久保古寿江
  • Organizer: 第13回日本神経麻酔・集中治療学会
  • Place of Presentation: 大阪(日本)
  • Year and Date: 2009-03-28
• [Presentation] ラット心肺停止・再灌流モデルにおけるエダラボンのミクログリア活性化と神経細胞傷害に対する影響 (2009)
  • Author(s): 久保古寿江、上村幸子、宮本悦子、阪本幸世、中尾慎一、新宮興
  • Organizer: 第13回日本神経麻酔・集中治療学会
  • Place of Presentation: 大阪
• [Presentation] Axonal damage follows neuronal damage in the rat hippocampus by global cerebral ischemia (2008)
  • Author(s): Kozue Kubo
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Orland (USA)
  • Year and Date: 2008-10-27
• [Presentation] ラットの心肺停止再濯流モデルでは、海馬CA1領域で神経細胞が障害され、βAPPの蓄積も亢進する (2008)
  • Author(s): 久保古寿江
  • Organizer: 日本麻酔学会第55回学術集会
  • Place of Presentation: 横浜(日本)
  • Year and Date: 2008-06-14
• [Presentation] The rat hippocampal CAI astrocytes were activated after transientglobal cerebral ischemia by cardiac arrest (2008)
  • Author(s): Kozue Kubo
  • Organizer: The 14th World Congress of Anaesthesiologists
  • Place of Presentation: Cape Town(South Africa)
  • Year and Date: 2008-03-04
• [Presentation] The rat hippocampal CA1 astrocytes were activated after transient global cerebral ischemia by cardiac arrest (2008)
  • Author(s): Kubo K, Jomura S, Nakao S, Shingu K
  • Organizer: The 14th World Congress of Anaesthesiologists
  • Place of Presentation: Cape Town
• [Presentation] Sevoflurane causes more prolongation of the QT interval in the aged than younger people (2008)
  • Author(s): Nakao S, Hatano K, Sumi C, Nikaido Y, Shingu K
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Orland
• [Presentation] The effect of sevoflurane and propofol with or without droperidol on the QT interval (2008)
  • Author(s): Sumi C, Nakao S, Hatano K, Ikeda S, Shingu K
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Orland
• [Presentation] Axonal damage follows neuronal damage in the rat hippocampus by global cerebral ischemia (2008)
  • Author(s): Kubo K, Jomura S, Miyamoto E, Shingu K, Nakao S
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Orland
• [Presentation] ラットの心肺停止再灌流モデルでは、海馬CA1領域で神経細胞が障害され、β-amyloid precursor protein(βAPP)の蓄積も亢進する (2008)
  • Author(s): 久保古寿江、上村幸子、宮本悦子、阪本幸世、中尾慎一、新宮興
  • Organizer: 日本麻酔科学会第55回学術集会
  • Place of Presentation: 横浜
• [Presentation] The effects ofpropofol on the sigma-1 receptor (2007)
  • Author(s): Shinichi Nakao
  • Organizer: World Congress of Total Intravenous Anesthesia
  • Place of Presentation: Venetia(Italy)
  • Year and Date: 2007-09-28
• [Presentation] 高血圧自然発症ラットにおける低二酸化炭素血症の大脳白質への影響 (2007)
  • Author(s): 宮本 悦子
  • Organizer: 日本麻酔科学会第548学術集会
  • Place of Presentation: 札幌(日本)
  • Year and Date: 2007-06-01
• [Presentation] The effects of propofol on the sigma-1 receptor (2007)
  • Author(s): Nakao S
  • Organizer: World congress of total intravenous anesthesia
  • Place of Presentation: Venice