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Human placental transfer of volatile anesthetic and its effect on the transfer of other drugs

Research Project

Project/Area Number 19591826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHyogo College of Medicine

Principal Investigator

SHIMODE Noriko  Hyogo College of Medicine, 医学部, 助教 (00351809)

Co-Investigator(Kenkyū-buntansha) TASHIRO Chikara  兵庫医科大学, 医学部, 病院長 (20107048)
UEKI Ryusuke  兵庫医科大学, 医学部, 助教 (10340986)
TATARA Tsuneo  兵庫医科大学, 医学部, 准教授 (30207039)
KARIYA Nobutaka  兵庫医科大学, 医学部, 准教授 (20305642)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords麻酔薬 / 胎盤移行 / 還流 / 産科麻酔 / 揮発性麻酔薬 / 灌流 / 産科 / 潅流
Research Abstract

We studied placental transfer of Sevoflurane(S) and Isoflurane(I) with human placental cotyledon model. We summarized the study of five extracted placenta. As the result, the average(SD) of concentration ratio between maternal artery and fetal vein was 0.145(±0.07) in S, 0.144(±0.06) in I, then there was no significant difference(p=0.992). By examination of further study, we succeed getting samples from seven placentas to calculate antipyrine clearance. Now, we are writing the report.

Report

(5 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Products Report
  • Research Products

    (8 results)

All 2014 2010 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Effect of decreased fetal perfusion on placental clearance of volatile anesthetics in a dual perfused human placental cotyledon model2014

    • Author(s)
      Ryusuke Ueki, Tsuneo Tatara, Nobutaka Kariya, Noriko Shimode, Munetaka Hirose, Chikara Tashiro
    • Journal Title

      Journal of Anesthesia

      Volume: 28 Issue: 4 Pages: 635-638

    • DOI

      10.1007/s00540-013-1777-3

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] Comparison of placental transfer for local anesthetics in the different perfusate pH in the human cotyledon model2009

    • Author(s)
      Ueki R, Tatara T, Kariya N, Shimode N, Tashiro C
    • Journal Title

      Journal of Anesthesia

      Pages: 526-529

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体監視装置2008

    • Author(s)
      狩谷 伸享
    • Journal Title

      ペリネイタルケア 345(増刊)

      Pages: 30-32

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 婦人科領域(子宮外妊娠,卵巣嚢腫,茎捻転)の緊急手術の麻酔2007

    • Author(s)
      狩谷 伸享
    • Journal Title

      救急・集中治療 19

      Pages: 1438-1443

    • Related Report
      2007 Annual Research Report
  • [Presentation] 太城力良ヒト胎盤小葉灌流モデルにおけるセボフルラン、イソフルランの胎盤移行性の検討2009

    • Author(s)
      植木隆介、狩谷伸享、大杉聡宏、下出典子、多田羅恒雄
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト胎盤小葉灌流モデルにおけるセボフルラン、イソフルランの胎盤移行性の検討2009

    • Author(s)
      植木隆介、狩谷伸亨、大杉聡宏、下出典子、多田羅恒雄、太城力良
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-17
    • Related Report
      2009 Annual Research Report
  • [Book] 検証責任エフェドリンかフェニレフリンか2010

    • Author(s)
      狩谷伸享、池本進一郎、井手岳、小濱華子、駒澤伸泰、富田有毅彦、山岡樹里、大杉聡宏、長尾嘉晃、井谷基、宮川慈子、植木隆介、下出典子、岡野紫、多田羅恒雄、太城力良
    • Publisher
      臨床麻酔
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.hyo-med.ac.jp/department/anes/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2021-08-25  

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