Fundamental research for clinical use of insulin-like growth factorin prostate cancer

• Project/Area Number: 19591833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: TSUCHIYA Norihiko Akita University, 医学部, 准教授 (70282176)
• Co-Investigator(Kenkyū-buntansha): YUASA Takeshi 秋田大学, 医学部, 講師 (00314162) ; KUMAZAWA Teruaki 秋田大学, 医学部, 助教 (60400488) ; INOUE Takamitsu 秋田大学, 医学部, 助教 (60375243)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 前立腺癌 / IGF-I / 遺伝子多型 / IGF-I受容体 / 遺伝子多 / 免疫染色

Research Abstract

IGF-I遺伝子多型の中でもpromoter領域に存在するCA反復多型、intron 2に存在するrs12423791、ハプロタイプブロック3に存在するrs7136446 とrs6220 は、進行性前立腺癌の癌特異的生存期間と全生存期間との間に有意な関連が認められ、これらが進行性前立腺癌の予後予測マーカーとして臨床応用される可能性が示された。

Research Products

• [Journal Article] Polymorphisms of fibroblastgrowth factor receptor 4 have associationwith the development of prostate cancer andbenign prostatic hyperplasia and theprogression of prostate cancer in a Japanesepopulation (2008)
  • Author(s): Ma Z, Tsuchiya N, Yuasa T, Inoue T,Kumazawa T, Narita S, Horikawa Y, TsurutaH, Obara T, Saito M, Satoh S, Ogawa O and Habuchi T
  • Journal Title: Int J Cancer 123 Pages: 2574-2579
  • Peer Reviewed
• [Journal Article] Prognostic significance ofHIF-1 alpha polymorphisms in transitionalcell carcinoma of the bladder (2008)
  • Author(s): Nadaoka J, Horikawa Y, Saito M,Kumazawa T, Inoue T, Narita S, Yuasa T,Satoh S, Nishiyama H, Ogawa O, TsuchiyaN and Habuchi T
  • Journal Title: Int J Cancer 122 Pages: 1297-1302
  • Peer Reviewed
• [Journal Article] A genetic polymorphism of theosteoprotegerin gene is associated with anincreased risk of advanced prostate cancer (2008)
  • Author(s): Narita N, Yuasa T, Tsuchiya N,Kumazawa T, Narita S, Inoue T, Ma Z, SaitoM, Horikawa Y, Satoh S, Ogawa O and Habuchi T
  • Journal Title: BMC Cancer 8 Pages: 224-232
  • Peer Reviewed
• [Journal Article] Candidate genes involved inenhanced growth of human prostate cancer (2008)
  • Author(s): Narita S, Tsuchiya N, Saito M, Inoue T,Kumazawa T, Yuasa T, Nakamura A and Habuchi T
  • Journal Title: under high fat feeding identified bymicroarray analysis. Prostate 68 Pages: 321-335
  • Peer Reviewed
• [Journal Article] Association ofgenetic polymorphisms at 8q24 with the riskof prostate cancer in a Japanese population (2008)
  • Author(s): Terada N, Tsuchiya N, Ma Z, Shimizu Y,Kobayashi T, Nakamura E, Kamoto T,Habuchi T and Ogawa O
  • Journal Title: Prostate 68 Pages: 1689-1695
  • Peer Reviewed
• [Journal Article] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prost ate cancer in a Japanese population (2008)
  • Author(s): Ma Z
  • Journal Title: Int J Cancer 123 Pages: 2574-2579
  • Peer Reviewed
• [Journal Article] Prognostic significance of HIF-1 alpha polymorphisms in transitional cell carcinoma of the bladder (2008)
  • Author(s): Nadaoka J
  • Journal Title: Int J Cancer 122 Pages: 1297-1302
  • Peer Reviewed
• [Journal Article] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer (2008)
  • Author(s): Narita N
  • Journal Title: BMC Cancer 8 Pages: 224-232
  • Peer Reviewed
• [Journal Article] Candidate genes involved in enhanced growth of human prostate cancer under high fat feeding identified by microarray analysis (2008)
  • Author(s): Narita S
  • Journal Title: Prostate 68 Pages: 321-335
  • Peer Reviewed
• [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population (2008)
  • Author(s): Terada N
  • Journal Title: Prostate 68 Pages: 1689-1695
  • Peer Reviewed
• [Journal Article] Prognostic significance of HIF-1 alpha polymorphisms in transitional cell carcinoma of the bladder. (2008)
  • Author(s): Nadaoka J, Horikawa Y, Saito M, Kumazawa T, et. al.
  • Journal Title: Int J Caner 15 Pages: 1297-1302
  • Peer Reviewed
• [Journal Article] Clinical implication of vascularendothelial growth factor T-460Cpolymorphism in the risk and progression ofprostate cancer (2007)
  • Author(s): Fukuda H, Tsuchiya N, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O and Habuchi T
  • Journal Title: Oncol Rep 18 Pages: 1155-1163
  • Peer Reviewed
• [Journal Article] Lowconcentrations of the histone deacetylaseinhibitor, depsipeptide, enhance the effectsof gemcitabine and docetaxel in hormonerefractory prostate cancer cells (2007)
  • Author(s): Kanzaki M, Kakinuma H, Kumazawa T,Inoue T, Saito M, Narita S, Yuasa T,Tsuchiya N and Habuchi T
  • Journal Title: Oncol Rep 17 Pages: 761-767
  • Peer Reviewed
• [Journal Article] 立腺癌の遺伝子多型研究. 前立腺癌-基礎・臨床研究のアップデート- (2007)
  • Author(s): 土谷順彦
  • Journal Title: 日本臨牀 65 Pages: 60-64
• [Journal Article] Clinical implication of vascular endothehal growth factor T-460C polymorphism in the risk and progression of prostate cancer. (2007)
  • Author(s): Fukuda H, Tsuchiya N, Nahta S, et. al.
  • Journal Title: Oncol Rep. 18 Pages: 1155-1163
  • Peer Reviewed
• [Journal Article] Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells. (2007)
  • Author(s): Kanzaki M, Kakinuma H, Kumazawa T, et. al.
  • Journal Title: Oncol Rep. 17 Pages: 761-767
  • Peer Reviewed
• [Presentation] ホルモン不応性前立腺癌細胞株に対するGLI2アンチセンスオリゴの抗腫瘍効果 (2008)
  • Author(s): 成田伸太郎
  • Organizer: 日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] miRNA181aはポリコーム群遺伝子Mel-18の発現を修飾し前立腺癌の進展に関与する (2008)
  • Author(s): 湯浅健
  • Organizer: 日本癌治療学会
  • Place of Presentation: 名古屋
• [Presentation] Geneexpression in response to high-fat feeding inhuman prostate cancer xenograft model (2007)
  • Author(s): Narita S, Tsuchiya N, Saito M, Inoue T,Kumazawa T, Horikawa Y, Yuasa T Matsuura S, Satoh S and Habuchi T
  • Organizer: AUA annual meeting
  • Place of Presentation: Atlanta
• [Presentation] Clinial implication of vascularendothelial growth factor (VEGF) T-460C (2007)
  • Author(s): Tsuchiya N, Fukuda H, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O. and Habuchi, T
  • Organizer: polymorphism in the risk and progression ofprostate cancer
  • Place of Presentation: AUA annual meeting, Atlanta
• [Presentation] 進行性前立腺癌の予後におけるhGH、IGF-I ならびにIL-6 遺伝子多型の関与 (2007)
  • Author(s): 土谷順彦, 成田伸太郎, 熊澤光明, 井上高光, 馬智勇, 齋藤満, 堀川洋平, 湯浅健, 松浦忍, 佐藤滋, 小川修, 羽渕友則
  • Organizer: 2007日本泌尿器科学会総会
  • Place of Presentation: 神戸
• [Presentation] A geneticpolymorphism of the Osteoprotegerin geneis associated with an increasing risk ofadvanced prostate cancer (2007)
  • Author(s): Narita N, Yuasa T, Tsuchiya N,Kumazawa T, Narita S, Saito M, Horikawa Y,Inoue T, Satoh S and Habuchi T
  • Organizer: 2007日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 進行性前立腺癌の予後におけるhGH、 IGF-IbならびにIL-6遺伝子多型の関与. (2007)
  • Author(s): 土谷順彦, 成田伸太郎, 熊澤光明, 他
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
• [Book] 前立腺癌リスクと遺伝子多型.泌尿器疾患治療の新しいストラテジー (2007)
  • Author(s): 土谷順彦
  • Publisher: メジカルビュー社
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~hinyoki/researcher/researchresults.html
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~hinyoki/researcher/rs2007.html