Elucidation of pathophysiology in voiding dysfunction after spinal cord injury and its treatments : a study on functional roles of spinal metabotropic glutamatergic mechanism
| Project/Area Number |
19591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
YOSHIYAMA Mitsuharu University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 (20422694)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hideki 山梨大学, 大学院・医学工学総合研究部, 助教 (50402053)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 代謝型グルタミン酸受容体 / 脊髄損傷 / 膀胱 / 外尿道括約筋 / 排尿障害 / マウス |
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| Research Abstract |
本研究は、下部尿路機能調節における仙髄代謝型グルタミン酸受容体(mGluR)経路の役割を検討した。mGluR1欠損マウスを用いた研究は、mGluR1が排尿時外尿道括約筋活動に対し抑制性であり、脊損後排尿障害との類似性を示した。mGluR5の薬理実験では、脊損マウスの膀胱収縮時外尿道括約筋活動に対しmGluR5が抑制性に制御することを明らかにした。これらの結果は、脊損後排尿障害の病態にmGluRが深く関わることを示唆する。
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Report
(3 results)
Research Products
(62 results)
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[Journal Article] Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice2008
Author(s)
Yoshiyama, M., Kobayashi, H., Araki, I., Du, S., Zakoji, H., and Takeda, M.
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Journal Title
Am. J. Physiol. Regul. Integr. Comp. Physiol 295
Pages: 954-960
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Peer Reviewed
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[Journal Article] Amiloride-sensitive ion channels in urinary bladder epithelium involved in mechanosensory transduction by modulating stretch-evoked adenosine triphosphate release2007
Author(s)
Du, S., Araki, I., Mikami, Y., Zakoji, H., Beppu, M., Yoshiyama, M., and Takeda, M.
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Journal Title
Urology 69
Pages: 590-595
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Peer Reviewed
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[Presentation] Effects of a metabotropic glutamate receptor subtype 5 antagonist on lower urinary tract functions in mice with normal or transected spinal cords2008
Author(s)
Yoshiyama, M., Araki, I., Kobayashi, H., Zakoji, H., and Takeda, M.
Organizer
International Continence Society 38th Annual Meeting
Place of Presentation
Cairo, Egypt
Related Report
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[Presentation] Involvements of metabotropic glutamate receptor subtype 5 (mGluR5) in control of lower urinary tract in mice with normal or transected spinal cords2008
Author(s)
Yoshiyama, M., Araki, I., Kobayashi, H., Zakoji, H., and Takeda, M.
Organizer
The 3rd Pan-Pacific Continence Society Meeting
Place of Presentation
Kaohsiung, Taiwan
Related Report
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[Presentation] Thr expression of prostaglandin E2 receptors (EP1, 2, 3, and 4) in the human urinary bladder epithelium of normal and bladder outlet obstruction - a novel mechanism in the afferent hyperactivity of bladder2008
Author(s)
Yuanjun, J. Kobayashi, H., Sawada, N., Yoshiyama, M., Mochizuki, T., Zakoji, H., Araki, I., and Takeda, M.
Organizer
American Urological Association
Place of Presentation
Orlando, Florida, U.S.A
Related Report
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[Presentation] Contribution of acid-sensing ion channels to gender difference in mouse bladder response to acetic acid : a novel candidate for interstitial cystitis pathogenesis2008
Author(s)
Kobayashi, H., Yoshiyama, M., Araki, I., Zakoji, H., Sawada, N., Mochizuki, T., Tsuchida, T., Nomura, T., Fukasawa, M., and Takeda, M.
Organizer
American Urological Association May
Place of Presentation
Orlando, Florida, U.S.A
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[Presentation] Irradiation induces detrusor overactivity studied acutely using a mouse model of radiation cystitis2007
Author(s)
Zabbarova, I., Roppolo, J., Yoshiyama, M., Ikeda, Y., McCarthy, C., Hagedorn, N., Birder, L., Fry, C., de Groat, W., and Kanai, A
Organizer
International Continence Society 37^<th> Annual Meeting
Place of Presentation
Rotterdam, The Netherlands
Related Report
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[Presentation] Acid-sensing ion channel : expression changes in the urinary bladder following chronic bladder inflammation2007
Author(s)
Kobayashi, H., Araki, I., Zakoji, H., Du, S., Sawada, N., Mochizuki, T., Yoshiyama, M., Tsuchida, T., Nomura, T., Fukasawa, M., Takihana, Y., and Takeda, M.
Organizer
International Continence Society 37^<th> Annual Meeting, Rotterdam
Place of Presentation
The Netherlands
Related Report
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[Presentation] The expression and the role of BK channels in the urinary bladder : the alteration of subunit expression profile in association with bladder outlet obstruction, and the affect of BK channel on afferent pathway in lower urinary tract2007
Author(s)
Zakoji, H., Araki, I., Beppu, M., Yoshiyama, M., Du, S., Kobayashi, H., Mochizuki, T., and Takeda, M.
Organizer
International Continence Society 37^<th> Annual Meeting, Rotterdam
Place of Presentation
The Netherlands
Related Report
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[Presentation] Additive control by metabotropic glutamate receptors 1 and 5 in bladder afferent mechanosensory transmission2007
Author(s)
Yoshiyama, M., Araki, I., Zakoji, H., Kobayashi, H., Du, S., Aiba, A., and Takeda, M.
Organizer
International Continence Society 37^<th> Annual Meeting
Place of Presentation
Rotterdam, The Netherlands
Related Report
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[Presentation] Photo-stimulating effects of low reactive level laser on micturition function in rats2007
Author(s)
Uchiyama, T., Sakakibara, R., Yoshiyama, M., Lui, Z., Yamamoto, T., Ito, T., Yamaguchi, C, Awa, Y., Yamanishi, T., and Hattori, T.
Organizer
International Continence Society 37^<th> Annual Meeting
Place of Presentation
Rotterdam, The Netherlands
Related Report
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[Presentation] Different cystometric responses between male and female mice to the lower urinary tract irritation by acetic acid2007
Author(s)
Yoshiyama, M., Araki, I., Kobayashi, H., Zakoji, H., Du, S., and Takeda, M.
Organizer
International Continence Society 37^<th> Annual Meeting
Place of Presentation
Rotterdam, The Netherlands
Related Report
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[Presentation] Role of metabotropic glutamate receptor subtype 1 in afferent processing of reflex micturition in mice2007
Author(s)
Yoshiyama, M., Araki, I., Zakoji, H. Kobayashi, H., Du, S., Aiba, A., and Takeda, M.
Organizer
American Urological Association
Place of Presentation
Anaheim, California, U.S.A.
Related Report
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[Presentation] The expression and role of large conductance, voltage- and Ca^<2+>-activated K^+ (BK) channels in the urinary bladder : the alteration of subunit expression profile in association with bladder outlet obstruction, and the affect of BK channel on the afferent ex2007
Author(s)
Zakoji, H., Araki, I., Beppu, M., Yoshiyama, M., Kobayashi, H., Du, S., Sawada, N., Mochizuki, T., Fukasawa, M., Takihana, Y., and Takeda, M.
Organizer
American Urological Association
Place of Presentation
Anaheim, California, U.S.A.
Related Report
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[Presentation] Amiloride-sensitive ion channels in urinary bladder epithelium involved in mechanosensory transduction by modulating stretch-evoked ATP release2007
Author(s)
Du, S., Araki, I., Mikami, Y., Yoshiyama, M., and Takeda, M.
Organizer
American Urological Association
Place of Presentation
Anaheim, California, U.S.A.
Related Report
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[Presentation] Agonists of transient receptor potential channel A1 cause hyper-reflexic micturition by affecting bladder afferent activity in rats2007
Author(s)
Du, S., Araki, I., Nomura, T., Yoshiyama, M., and Takeda, M.
Organizer
American Urological Association
Place of Presentation
Anaheim, California, U.S.A.
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