Development of novel therapies based on the progression mechanism in prostate cancer involving the seminal vesicle

• Project/Area Number: 19591848
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: MIYAKE Hideaki Kobe University, 医学部附属病院, 講師 (60379435)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 前立腺癌, / 精嚢 / TGFβ / uPA / アンチセンス / 前立腺癌 / 根治的前立腺全摘除術 / 精嚢浸潤 / 微小環境 / 生化学的再発 / アンチセンスオリゴ / TGF β

Research Abstract

精嚢抽出液の添加により前立腺癌細胞の浸潤能の顕著な亢進が認められ,この現象が精嚢抽出液中のTGFβによるuPAの発現誘導によるものであることを証明した.また,前立腺癌におけるuPA/uPA receptor systemが,根治的前立腺全摘除術施行後の予後に重要な役割を果たすことを明らかにした.

Research Products

• [Journal Article] Enhanced progression of human prostate cancer PC3 cells induced by the microenvironment of the seminal vesicle. (2008)
  • Author(s): Kumano M, Miyake H, Kurahashi T, Yamanaka K, Fujisawa M
  • Journal Title: British Journal of Cancer 98 Pages: 356-362
  • Peer Reviewed
• [Journal Article] oligo DNA,siRNAによる治療の展望 (2008)
  • Author(s): 三宅秀明,藤澤正人
  • Journal Title: Urology View 6 Pages: 98-104
• [Journal Article] oligo DNA, siRNAによる治療の展望 (2008)
  • Author(s): 三宅秀明, 他1名, 1番目
  • Journal Title: Urology View 6 Pages: 98-104
• [Journal Article] Enhanced progression of human prostate cancer PC3 cells induced by the microenvironment of the seminal vesicle (2008)
  • Author(s): Miyake H(他4名, 2番目)
  • Journal Title: Br J Cancer 98巻・第2号 Pages: 335-362
  • Peer Reviewed
• [Journal Article] Expression of potential molecular markers in prostate cancer : correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
  • Author(s): Miyake H, Muramaki M, Kurahashi T, Takenaka A, Fujisawa M
  • Journal Title: Urologic Oncology Pages: 0-0
  • Peer Reviewed
• [Journal Article] Expression of urokinase-type plasminogen activator system in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
  • Author(s): Kumano M, Miyake H, Muramaki M, Furukawa J, Takenaka A, Fujisawa M
  • Journal Title: Urologic Oncology Pages: 0-0
  • Peer Reviewed
• [Journal Article] Expression of urokinase-type plasminogen activator system in prostatecancer : correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
  • Author(s): Miyake H, 他5名, 2番目
  • Journal Title: Urol Oncol (掲載確定) in press
  • Peer Reviewed
• [Journal Article] Expression of potential molecular markers in prostate cancer : correlation with clinicnpatliological outcomes in patients undergoing radical prostatectomy
  • Author(s): Miyake H, 他5名, 1番目
  • Journal Title: Urol Oncol (掲載確定) in press
  • Peer Reviewed
• [Journal Article] Expression of urokinase-type plasminogen activator system in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
  • Author(s): Miyake H(他5名, 2番目)
  • Journal Title: Urol Oncol (in press)
  • Peer Reviewed
• [Presentation] Enhanced progression of human prostate cancer PC3 cells by the microenvironment of the seminal vesicle (2008)
  • Author(s): Kumano M, Miyake H, Takenaka A, Kamidono S, Fujisawa M
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2008-05-20
• [Presentation] 精嚢微小環境による前立腺癌悪性形質の亢進 (2008)
  • Author(s): 熊野晶文,三宅秀明,田中一志,武中篤,藤澤正人
  • Organizer: 第17回泌尿器科分子・細胞研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-16