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Implication of FGFR in loss of hormone dependency of prostate cancer and its application to new therapy for prostate cancer

Research Project

Project/Area Number 19591852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionHiroshima University

Principal Investigator

MATSUBARA Akio  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (10239064)

Co-Investigator(Kenkyū-buntansha) MITA Koji  広島大学, 病院, 講師 (70304425)
TEISHIMA Jun  広島大学, 大学院・医歯薬学総合研究科, 助教 (20397962)
HASEGAWA Yasuhisa  広島大学, 病院, 助教 (90403568)
OHARA Shinya  広島大学, 病院, 医員 (70444693)
YASUMOTO Hiroaki  広島大学, 大学院・医歯薬学総合研究科, 助教 (20314750)
Research Collaborator SEKI Mitsuhiro  広島大学, 大学院・医歯薬学総合研究科, 助教 (80372697)
HAYASHI Tetsutaro  広島大学, 大学院・医歯薬学総合研究科, 大学院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords線維芽細胞成長因子 / FGFR / チロシンキナーゼ / 増殖抑制 / 分化 / 前立腺癌 / 放射線治療 / 遺伝子治療 / 線維芽細胞成長因子受容体
Research Abstract

本研究者らはホルモン不応性前立腺がんに対してチロシンキナーゼの1つFGFR2を移入することによって増殖が有意に抑制されると共にホルモン依存性の特性を部分的に回復する実験結果をもとに、これまでホルモン不応性前立腺がんに対するFGFR2導入療法の前臨床試験を行ってきた。一方、ホルモン不応性前立腺がんとFGFR2の遺伝子変異の関係も合わせて検討してきたが、現時点では予想される結果は得られていない。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (22 results)

  • [Journal Article] Restoration of FGF receptor type 2 enhances radiosensitivity of hormone-refractory human prostate carcinoma PC-3 cells2009

    • Author(s)
      Matsubara Akio, Teishima Jun, Mirkhat Suichinov, Yasumoto Hiroaki, Seki Mitsuhiro
    • Journal Title

      Anticancer Res 21

      Pages: 2141-2146

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utilityas serum tumor marker2009

    • Author(s)
      Hayashi Tetsutaro, Matsubara Akio, Ohara Shinya, Mita Koji, Hasegawa Yasuhisa
    • Journal Title

      Oncol Rep 21

      Pages: 95-100

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of FGF receptor type 2 enhances radiosensitivity of hormone-refractory human prostate carcinoma PC-3 cells.2009

    • Author(s)
      Matsubara A
    • Journal Title

      Anticancer Res. 21

      Pages: 2141-2146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker.2009

    • Author(s)
      Hayashi T
    • Journal Title

      Oncol Rep. 21

      Pages: 95-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer2008

    • Author(s)
      Ohara Shinya, Matsubara Akio, Mita Koji, Hasegawa Yasuhisa, Hayashi Tetsutaro
    • Journal Title

      Cancer Sci 99

      Pages: 1570-1577

    • NAID

      10024009713

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer.2008

    • Author(s)
      Ohara S
    • Journal Title

      Cancer Sci. 99

      Pages: 1570-1577

    • NAID

      10024009713

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer2007

    • Author(s)
      Hasegawa Yasuhisa, Matsubara Akio, Jun Teishima, Seki Mitsuhiro
    • Journal Title

      Cancer Sci 98

      Pages: 32-36

    • NAID

      120000875846

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer2007

    • Author(s)
      HASEGAWA YASUHISA
    • Journal Title

      Cancer Sci 98

      Pages: 32-36

    • NAID

      120000875846

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Implication of FGFR in loss of hormone dependency of prostate cancer and its application to new therapy for prostate cancer2009

    • Author(s)
      Akio Matsubara
    • Organizer
      The international Workshop on biodental education & research
    • Place of Presentation
      Hiroshima
    • Related Report
      2008 Final Research Report
  • [Presentation] Implication of FGFR in loss of hormone dependency of prostate cancer and its application to new therapy for prostate cancer.2009

    • Author(s)
      Akio Matsubara
    • Organizer
      The international Workshop on biodental education & research
    • Place of Presentation
      Hiroshima
    • Related Report
      2008 Annual Research Report
  • [Presentation] Search for secreted and transmembrane protein in prostate cancer using CAST2008

    • Author(s)
      Tetsutaro Hayashi
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Final Research Report
  • [Presentation] RegIV expression in cancer of the prostate, kidoney,and urinary tract : frequent expression of RegIV in prostate cancer2008

    • Author(s)
      Shinya Ohara
    • Organizer
      第67回日本癌学会総
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Final Research Report
  • [Presentation] 前立腺癌におけるRegIVとEGFRの発現関連2008

    • Author(s)
      大原慎也
    • Organizer
      第97回日本病理学会総
    • Place of Presentation
      金沢市
    • Related Report
      2008 Final Research Report
  • [Presentation] 尿路系腫瘍におけるRegIVの発現と神経内分泌への分化に関する検討2008

    • Author(s)
      林哲太郎
    • Organizer
      第97回日本病理学会総
    • Place of Presentation
      金沢市
    • Related Report
      2008 Final Research Report
  • [Presentation] RegIV expression in cancer of the prostate, kidoney, and urinary tract : frequent expression of RegIV in prostate cancer2008

    • Author(s)
      Shinya Ohara
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Search for secreted and transmembrane protein in prostate cancer using CAST.2008

    • Author(s)
      Tetsutaro Hayashi
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前立腺癌におけるRegIVとEGFRの発現の関連2008

    • Author(s)
      大原 慎也
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 尿路系腫瘍におけるRegIVの発現と神経内分泌への分化に関する検討2008

    • Author(s)
      林 哲太郎
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Guanine nucleotide binding protein-like 3 はestrogen-related receptorγの転写活性を阻害する2007

    • Author(s)
      安本博晃
    • Organizer
      第15回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-11-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 線維芽細胞成長因子受容体2と放射線, ドセタキセルの併用によるヒト前立腺癌細胞の増殖抑制2007

    • Author(s)
      亭島淳
    • Organizer
      第15回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-11-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 線維芽細胞成長因子受容体2と放射線、ドセタキセルの併用によるヒト前立腺癌細胞の増殖抑制2007

    • Author(s)
      亭島 淳
    • Organizer
      第15回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Guanine nucleotide binding protein-like 3はestrogen-related receptor γの転写活性を阻害する2007

    • Author(s)
      安本博晃
    • Organizer
      第15回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Reg IV is an independent prognostic indicator of relapse of prostate cance2007

    • Author(s)
      Shinya Ohara
    • Organizer
      The 17th international symposium of Hiroshima cancer seminar Hiroshima
    • Place of Presentation
      広島市
    • Year and Date
      2007-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Reg IV is an independent prognostic indicator of relapse of prostate cancer2007

    • Author(s)
      S. Ohara,
    • Organizer
      The 17th international symposium of Hiroshima cancer seminar Hiroshima
    • Place of Presentation
      Hiroshima
    • Year and Date
      2007-11-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impact of radiation and docetaxel on anti-tumor effects of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) inhormone-refractory human prostate cancer cells2007

    • Author(s)
      Akio Matsubara
    • Organizer
      98th AACR (American Association for Cancer Research) Annual Meeting
    • Place of Presentation
      Los Angeles, CA USA
    • Year and Date
      2007-04-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Impact of radiation and docetaxel on anti-tumor effects of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in hormone-refractory human prostate cancer cells2007

    • Author(s)
      A. Matsubara
    • Organizer
      98th AACR (American Association for Cancer Research) Annual Meeting
    • Place of Presentation
      Los Angeles, CA USA
    • Year and Date
      2007-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前立腺癌におけるRIZ1遺伝子の発現とDNA メチル化の解析2007

    • Author(s)
      長谷川泰久
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸市
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト前立腺癌細胞の放射線感受性およびDocetaxel の抗癌効果に及ぼすIGFBP-rP1の効果2007

    • Author(s)
      石光広
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸市
    • Related Report
      2008 Final Research Report
  • [Presentation] 前立腺癌におけるRIZ1遺伝子の発現とDNAメチル化の解析2007

    • Author(s)
      長谷川泰久
    • Organizer
      第95向日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト前立腺癌細胞の放射線感受性およぴDocetaxelの抗癌効果に及ぼすIGFBP-rP1の効果2007

    • Author(s)
      石 光広
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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