Influence of immunotherapy with interferon-alpha and the efficacy of interferon combined with dendritic therapy on renal cell carcinoma

• Project/Area Number: 19591855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyushu University
• Principal Investigator: TATSUGAM Katsunor (TATSUGAMI Katsunori) Kyushu University, 大学病院, 講師 (90380617)
• Co-Investigator(Kenkyū-buntansha): ETO Masatoshi 九州大学, 大学病院, 講師 (90315078) ; HARANO Masahiko 九州大学, 大学病院, 助教 (90380451) ; HAMAGUCHI Masukitsu 九州大学, 大学病院, 医員 (40419578)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腎細胞癌 / 免疫療法 / インターフェロン / 樹状細胞 / 抑制性T細胞 / 樹状細胞療法 / 分子標的治療薬 / ソラフェニブ

Research Abstract

We examined the efficacy of immunotherapy combined with cytokines (IFN-a and IL-2) and the impact of the immunotherapy on host immunity in RCC patients. We found that regulatory T cells result in inducing negative effect in recipients received with immunotherapy such as cytokine-therapy or nonmyeloablative allogeneic cell therapy. We also indicated that targeted drugs- or dendritic cells-therapy combined with IFN-a administration is feasible and safe, and the treatment has the potential for prolonging the time to progression in advanced RCC.

Research Products

• [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients. (2010)
  • Author(s): Tatsugami K, Etc M, Naito S.
  • Journal Title: J Interferon Cytokine Res. 30(1) Pages: 43-48
• [Journal Article] Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma. (2010)
  • Author(s): Takeuchi A, Eto M, Tatsugami K, Yamada H, Oki T, Kiyoshima K, Yoshikai Y, Naito S.
  • Journal Title: J Urol. 184(6) Pages: 2549-2556
• [Journal Article] Immunotherapy for renal cell carcinoma. (2010)
  • Author(s): Itsumi M, Tatsugami K.
  • Journal Title: Clin Dev Immunol. Pages: 284581-284581
• [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients. (2010)
  • Author(s): Tatsugami K, Eto M, Naito S
  • Journal Title: J Interferon Cytokine Res. Volume: 1 Pages: 43-48
  • Peer Reviewed
• [Journal Article] Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma. (2010)
  • Author(s): Takeuchi A, Eto M, Tatsugami K, et al.
  • Journal Title: J Urol. Volume: 1 Pages: 2549-56
  • Peer Reviewed
• [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients (2010)
  • Author(s): Tatsugami K, Eto M, Naito S
  • Journal Title: J Interferon Cytokine Res. 1 Pages: 43-48
  • Peer Reviewed
• [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation. (2009)
  • Author(s): Hamaguchi M, Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Teshima T, Harada M, Yoshikai Y, Naito S.
  • Journal Title: Cancer Sci 100(1) Pages: 138-143
  • NAID: 10025141672
• [Journal Article] Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor. (2009)
  • Author(s): Kamiryo Y, Eto M, Yamada H, Yajima T, Harano M, Takeuchi A, Tatsugami K, Hamaguchi M, Naito S, Yoshikai Y.
  • Journal Title: Cancer Res. 69(12) Pages: 5151-5158
• [Journal Article] Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor (2009)
  • Author(s): Kamiryo Y, Eto M, Yamada H, Yajima T, Harano M, Takeuchi A, Tatsugami K, Hamaguchi M, Naito S, Yoshikai Y.
  • Journal Title: Cancer Res. 69(12) Pages: 5151-8
• [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation (2009)
  • Author(s): Hamaguchi M, Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Teshima T, Harada M, Yoshikai Y, Naito S
  • Journal Title: Cancer Sci 100(1) Pages: 138-143
  • NAID: 10025141672
• [Journal Article] Dendritic cell therapy in combination with interferon-α for the treatment of metastatic renal cell carcinoma. (2008)
  • Author(s): Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito S.
  • Journal Title: Int J Urol 15(8) Pages: 694-698
  • NAID: 10021939827
• [Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor. (2008)
  • Author(s): Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Harada M, Kiyoshima K, Hamaguchi M, Teshima T, Tsuneyoshi M, Yoshikai Y, Naito S.
  • Journal Title: Clin Cancer Res 14(9) Pages: 2833-2840
• [Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor (2008)
  • Author(s): Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Harada M, Kiyoshima K, Hamaguchi M, Teshima T, Tsuneyoshi M, Yoshikai Y, Naito S
  • Journal Title: Clin Cancer Res 14(9) Pages: 2833-2840
• [Journal Article] Dendritic cell therapy in combination with interferon-α for the treatment of metastatic renal cell carcinoma (2008)
  • Author(s): Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito S
  • Journal Title: Int J Urol 15(8) Pages: 694-698
  • NAID: 10021939827
• [Journal Article] Dendritic cell therapy in combination with interferon-alpha for the treatment of metastatic renal cell carcinoma. (2008)
  • Author(s): Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito s.
  • Journal Title: International Journal of Urology 8 Pages: 694-698
  • Peer Reviewed
• [Journal Article] Cyclophosphamide-using nonmyeloablative allogeneic cell therapy against renal cancer with a reduced risk of graft-versus-host disease. (2007)
  • Author(s): Eto M, Harano M, Tatsugami K, Harada M, Kamiryo Y, Kiyoshima K, Hamaguchi M, Tsuneyoshi M, Yoshikai Y, Naito S.
  • Journal Title: Clin Cancer Res 13(3) Pages: 1029-1035
• [Presentation] マウス膀胱癌に対するcyclophosphamideを用いたミニ移植モデルにおいてホストの制御性T細胞の抑制は重要である (2009)
  • Author(s): 江藤正俊, ら
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
• [Presentation] Mechanistic analysis of synergistic antitumor effects of interferon-α and sorafenib in renal cell carcinoma. (2009)
  • Author(s): 江藤正俊, et al.
  • Organizer: The 104th Annual Meeting AUA Chicago
  • Place of Presentation: USA
• [Presentation] 腎細胞癌患者に対するインターフェロン療法による抑制性T細胞への影響 (2008)
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 腎細胞m患者に対するインターフェロン療法による抑制性T細胞への影響 (2008)
  • Author(s): 立神勝則, 江藤正俊, 内藤誠二
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] In vitro and in vivo analysis of synergistic antitumor effects of interferon-α and sorafenib in renal cell carcinoma. (2008)
  • Author(s): 江藤正俊, et al.
  • Organizer: 44th Annual Meeting of the American Society of Clinical Oncology Chicago
  • Place of Presentation: Illinois
• [Presentation] マウス固形癌に対するcyclophosphamideを用いたミニ移植モデルにおいてホストの制御性T細胞の抑制は重要である (2008)
  • Author(s): 江藤正俊, ら
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 腎細胞癌患者に対するインターフェロン療法による抑制性T細胞への影響 (2008)
  • Author(s): 立神勝則, ら
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Sorafenib、Interferon-α併用による抗腫瘍効果増強の作用機序の基礎的検討 (2008)
  • Author(s): 江藤正俊, ら
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 腎癌に対するサイトカイン療法が抑制性T細胞に与える影響についての検討 (2007)
  • Organizer: 日本泌尿器科学会西日本総会
  • Place of Presentation: 松山・松山全日空ホテル
  • Year and Date: 2007-11-10
• [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討 (2007)
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都・国立京都国際会館
  • Year and Date: 2007-10-26
• [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討 (2007)
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 神戸・神戸国際展示場
  • Year and Date: 2007-04-14
• [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響たついての検討 (2007)
  • Author(s): 立神 勝則
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 神戸・神戸国際展示場
  • Year and Date: 2007-04-14
• [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響について (2007)
  • Author(s): 立神勝則, ら
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
• [Presentation] Vaccination of donors with tumor antigen peptides enhances the antitumor effect on solid tumors in recipient mice with nonmyeloablative allogeneic hemopoietic cell transplantation. (2007)
  • Author(s): 江藤正俊, et al.
  • Organizer: The 102th AUA Annual Meeting Anaheim
  • Place of Presentation: USA
• [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討 (2007)
  • Author(s): 立神勝則, ら
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
• [Presentation] 腎癌に対するサイトカイン療法が抑圧性T細胞に与える影響について (2007)
  • Author(s): 立神勝則, ら
  • Organizer: 第59回日本泌尿器科学会西日本総会
  • Place of Presentation: 松山
• [Book] 腎細胞癌に対する免疫細胞療法腎と透析66(6) (2009)
  • Author(s): 立神勝則、江藤正俊
  • Total Pages: 1028
• [Book] 泌尿器科専門医にきく最新の臨床(腎癌に対する細胞免疫療法-LAK療法から樹状細胞療法、ミニ移植まで-について教えて下さい) (2008)
  • Author(s): 立神勝則、江藤正俊
• [Book] 腎細胞癌に対する細胞療法の展望泌尿器科疾患の新しいストラテジー (2007)
  • Author(s): 立神勝則、江藤正俊、内藤誠二
• [Remarks] ホームページ等