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Influence of immunotherapy with interferon-alpha and the efficacy of interferon combined with dendritic therapy on renal cell carcinoma

Research Project

Project/Area Number 19591855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKyushu University

Principal Investigator

TATSUGAM Katsunor (TATSUGAMI Katsunori)  Kyushu University, 大学病院, 講師 (90380617)

Co-Investigator(Kenkyū-buntansha) ETO Masatoshi  九州大学, 大学病院, 講師 (90315078)
HARANO Masahiko  九州大学, 大学病院, 助教 (90380451)
HAMAGUCHI Masukitsu  九州大学, 大学病院, 医員 (40419578)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腎細胞癌 / 免疫療法 / インターフェロン / 樹状細胞 / 抑制性T細胞 / 樹状細胞療法 / 分子標的治療薬 / ソラフェニブ
Research Abstract

We examined the efficacy of immunotherapy combined with cytokines (IFN-a and IL-2) and the impact of the immunotherapy on host immunity in RCC patients. We found that regulatory T cells result in inducing negative effect in recipients received with immunotherapy such as cytokine-therapy or nonmyeloablative allogeneic cell therapy. We also indicated that targeted drugs- or dendritic cells-therapy combined with IFN-a administration is feasible and safe, and the treatment has the potential for prolonging the time to progression in advanced RCC.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 4 results) Presentation (16 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients.2010

    • Author(s)
      Tatsugami K, Etc M, Naito S.
    • Journal Title

      J Interferon Cytokine Res. 30(1)

      Pages: 43-48

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma.2010

    • Author(s)
      Takeuchi A, Eto M, Tatsugami K, Yamada H, Oki T, Kiyoshima K, Yoshikai Y, Naito S.
    • Journal Title

      J Urol. 184(6)

      Pages: 2549-2556

    • Related Report
      2010 Final Research Report
  • [Journal Article] Immunotherapy for renal cell carcinoma.2010

    • Author(s)
      Itsumi M, Tatsugami K.
    • Journal Title

      Clin Dev Immunol.

      Pages: 284581-284581

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients.2010

    • Author(s)
      Tatsugami K, Eto M, Naito S
    • Journal Title

      J Interferon Cytokine Res.

      Volume: 1 Pages: 43-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma.2010

    • Author(s)
      Takeuchi A, Eto M, Tatsugami K, et al.
    • Journal Title

      J Urol.

      Volume: 1 Pages: 2549-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients2010

    • Author(s)
      Tatsugami K, Eto M, Naito S
    • Journal Title

      J Interferon Cytokine Res. 1

      Pages: 43-48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation.2009

    • Author(s)
      Hamaguchi M, Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Teshima T, Harada M, Yoshikai Y, Naito S.
    • Journal Title

      Cancer Sci 100(1)

      Pages: 138-143

    • NAID

      10025141672

    • Related Report
      2010 Final Research Report
  • [Journal Article] Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor.2009

    • Author(s)
      Kamiryo Y, Eto M, Yamada H, Yajima T, Harano M, Takeuchi A, Tatsugami K, Hamaguchi M, Naito S, Yoshikai Y.
    • Journal Title

      Cancer Res. 69(12)

      Pages: 5151-5158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor2009

    • Author(s)
      Kamiryo Y, Eto M, Yamada H, Yajima T, Harano M, Takeuchi A, Tatsugami K, Hamaguchi M, Naito S, Yoshikai Y.
    • Journal Title

      Cancer Res. 69(12)

      Pages: 5151-8

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation2009

    • Author(s)
      Hamaguchi M, Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Teshima T, Harada M, Yoshikai Y, Naito S
    • Journal Title

      Cancer Sci 100(1)

      Pages: 138-143

    • NAID

      10025141672

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dendritic cell therapy in combination with interferon-α for the treatment of metastatic renal cell carcinoma.2008

    • Author(s)
      Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito S.
    • Journal Title

      Int J Urol 15(8)

      Pages: 694-698

    • NAID

      10021939827

    • Related Report
      2010 Final Research Report
  • [Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor.2008

    • Author(s)
      Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Harada M, Kiyoshima K, Hamaguchi M, Teshima T, Tsuneyoshi M, Yoshikai Y, Naito S.
    • Journal Title

      Clin Cancer Res 14(9)

      Pages: 2833-2840

    • Related Report
      2010 Final Research Report
  • [Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor2008

    • Author(s)
      Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Harada M, Kiyoshima K, Hamaguchi M, Teshima T, Tsuneyoshi M, Yoshikai Y, Naito S
    • Journal Title

      Clin Cancer Res 14(9)

      Pages: 2833-2840

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dendritic cell therapy in combination with interferon-α for the treatment of metastatic renal cell carcinoma2008

    • Author(s)
      Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito S
    • Journal Title

      Int J Urol 15(8)

      Pages: 694-698

    • NAID

      10021939827

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dendritic cell therapy in combination with interferon-alpha for the treatment of metastatic renal cell carcinoma.2008

    • Author(s)
      Tatsugami K, Eto M, Harano M, Hamaguchi M, Miyamoto T, Morisaki T, Furue M, Akashi K, Naito s.
    • Journal Title

      International Journal of Urology 8

      Pages: 694-698

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclophosphamide-using nonmyeloablative allogeneic cell therapy against renal cancer with a reduced risk of graft-versus-host disease.2007

    • Author(s)
      Eto M, Harano M, Tatsugami K, Harada M, Kamiryo Y, Kiyoshima K, Hamaguchi M, Tsuneyoshi M, Yoshikai Y, Naito S.
    • Journal Title

      Clin Cancer Res 13(3)

      Pages: 1029-1035

    • Related Report
      2010 Final Research Report
  • [Presentation] マウス膀胱癌に対するcyclophosphamideを用いたミニ移植モデルにおいてホストの制御性T細胞の抑制は重要である2009

    • Author(s)
      江藤正俊, ら
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanistic analysis of synergistic antitumor effects of interferon-α and sorafenib in renal cell carcinoma.2009

    • Author(s)
      江藤正俊, et al.
    • Organizer
      The 104th Annual Meeting AUA Chicago
    • Place of Presentation
      USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎細胞癌患者に対するインターフェロン療法による抑制性T細胞への影響2008

    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 腎細胞m患者に対するインターフェロン療法による抑制性T細胞への影響2008

    • Author(s)
      立神勝則, 江藤正俊, 内藤誠二
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] In vitro and in vivo analysis of synergistic antitumor effects of interferon-α and sorafenib in renal cell carcinoma.2008

    • Author(s)
      江藤正俊, et al.
    • Organizer
      44th Annual Meeting of the American Society of Clinical Oncology Chicago
    • Place of Presentation
      Illinois
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス固形癌に対するcyclophosphamideを用いたミニ移植モデルにおいてホストの制御性T細胞の抑制は重要である2008

    • Author(s)
      江藤正俊, ら
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎細胞癌患者に対するインターフェロン療法による抑制性T細胞への影響2008

    • Author(s)
      立神勝則, ら
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Sorafenib、Interferon-α併用による抗腫瘍効果増強の作用機序の基礎的検討2008

    • Author(s)
      江藤正俊, ら
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎癌に対するサイトカイン療法が抑制性T細胞に与える影響についての検討2007

    • Organizer
      日本泌尿器科学会西日本総会
    • Place of Presentation
      松山・松山全日空ホテル
    • Year and Date
      2007-11-10
    • Related Report
      2009 Self-evaluation Report 2007 Annual Research Report
  • [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討2007

    • Organizer
      日本癌治療学会
    • Place of Presentation
      京都・国立京都国際会館
    • Year and Date
      2007-10-26
    • Related Report
      2009 Self-evaluation Report 2007 Annual Research Report
  • [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討2007

    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      神戸・神戸国際展示場
    • Year and Date
      2007-04-14
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響たついての検討2007

    • Author(s)
      立神 勝則
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      神戸・神戸国際展示場
    • Year and Date
      2007-04-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響について2007

    • Author(s)
      立神勝則, ら
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Vaccination of donors with tumor antigen peptides enhances the antitumor effect on solid tumors in recipient mice with nonmyeloablative allogeneic hemopoietic cell transplantation.2007

    • Author(s)
      江藤正俊, et al.
    • Organizer
      The 102th AUA Annual Meeting Anaheim
    • Place of Presentation
      USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎癌に対するIFN-α療法が抑制性T細胞に与える影響についての検討2007

    • Author(s)
      立神勝則, ら
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎癌に対するサイトカイン療法が抑圧性T細胞に与える影響について2007

    • Author(s)
      立神勝則, ら
    • Organizer
      第59回日本泌尿器科学会西日本総会
    • Place of Presentation
      松山
    • Related Report
      2010 Final Research Report
  • [Book] 腎細胞癌に対する免疫細胞療法腎と透析66(6)2009

    • Author(s)
      立神勝則、江藤正俊
    • Total Pages
      1028
    • Related Report
      2010 Final Research Report
  • [Book] 泌尿器科専門医にきく最新の臨床(腎癌に対する細胞免疫療法-LAK療法から樹状細胞療法、ミニ移植まで-について教えて下さい)2008

    • Author(s)
      立神勝則、江藤正俊
    • Related Report
      2010 Final Research Report
  • [Book] 腎細胞癌に対する細胞療法の展望泌尿器科疾患の新しいストラテジー2007

    • Author(s)
      立神勝則、江藤正俊、内藤誠二
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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