Reconstruction of lower urinary tract function by transplantation of bone marrow cells into the brain and spinal cord in rats with overactive bladder

• Project/Area Number: 19591861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: University of the Ryukyus
• Principal Investigator: SUGAYA Kimio University of the Ryukyus, 医学部, 准教授 (20179120)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 過活動膀胱 / 骨髄間質細胞 / 移植 / 脳梗塞

Research Abstract

排尿障害を呈する脳梗塞ラットまたは脊髄損傷ラットの脳脊髄髄腔内へ骨髄間質細胞を移植し、下部尿路機能の再構築の可能性について検討した。その結果、ドナー由来の移植細胞は脳や脊髄に定着し、一部のラットでは移植由来細胞は神経様細胞に分化しており、排尿障害も部分的に改善された。

Research Products

• [Journal Article] Restoration of bladder contraction by bone marrow transplantation in rats with underactive bladder (2007)
  • Author(s): Nishijima S, Sugaya K, Miyazato M,Kadekawa K, Oshiro Y, Uchida A, Hokama S, Ogawa Y.
  • Journal Title: Biomed Res 28 Pages: 275-280
  • NAID: 130004903742
  • Peer Reviewed
• [Journal Article] Restoration of bladder contraction by bone marrow transplantation in rats with underactive bladder. (2007)
  • Author(s): Nishijima S, Sugaya K, Miyazato M, Kadekawa K, Oshiro Y, Uchida A, Hokama S, Ogawa Y.
  • Journal Title: Biomed Res 28(5) Pages: 275-280
  • NAID: 130004903742
  • Peer Reviewed