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Development of the novel therapies targeting oncogenic signals of renal cell carcinoma

Research Project

Project/Area Number 19591864
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

NAKAIGAWA Noboru  Yokohama City University, 附属病院, 准教授 (00237207)

Co-Investigator(Kenkyū-buntansha) YAO Masahiro  横浜市立大学, 医学研究科, 准教授 (00260787)
KISHIDA Takeshi  横浜市立大学, 附属病院, 准教授 (60254166)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsトランスレーショナルリサーチ癌細胞 / 組織遺伝子 プロテオーム / トランスレーショナルリサーチ / 癌 / 細胞・組織 / 遺伝子 / プロテオーム
Research Abstract

肝細胞成長因子の受容体型チロシンキナーゼであるMET蛋白が腎細胞癌の発癌メカニズムの中で、増殖、生存能、上皮間葉転換、運動能、血管新生といった様々なstepにおいて重要な働きをしていること、このMET蛋白が腎細胞癌の新規治療標的となることを明らかにしました。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Retroperitoneoscopic nephrectomy in overweight and obese Japanese patients : complications and outcomes2008

    • Author(s)
      Makiyama K, Nakaigawa N, Miyoshi Y, Murakami T, Yao M, Kubota Y.
    • Journal Title

      Urol Int. 81(4)

      Pages: 427-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Aquaporin 1 in Primary Renal Tumors : A Prognostic Indicator for Clear-Cell Renal Cell Carcinoma2008

    • Author(s)
      Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kubota Y, Nagashima Y, Yao M
    • Journal Title

      Eur Urol.

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement on parenchymal suturing technique in laparoscopic partial nephrectomy2008

    • Author(s)
      Makiyama K, Nakaigawa N, Miyoshi Y, Murakami T, Yao M, Kubota Y.
    • Journal Title

      Int J Urol 15(9)

      Pages: 854-5

    • NAID

      10022611700

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma2008

    • Author(s)
      Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
    • Journal Title

      Int J Cancer. 123(5)

      Pages: 1126-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 非淡明細胞の臨床はどう変化する2008

    • Author(s)
      中井川昇, 岸田健, 矢尾正祐, 窪田吉信
    • Journal Title

      Urology Review 6(4)

      Pages: 78-84

    • Related Report
      2008 Final Research Report
  • [Journal Article] これからはじまる進行腎がんに対する分子標的薬治療VHLを中心に2008

    • Author(s)
      矢尾正弘, 中井川昇, 近藤慶一, 岸田健
    • Journal Title

      Urology Review 6(4)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Expression of Aquaporin 1 in Primay Renal Tumors : A Prognostic Indicator for Clear-Cell Renal Cell Carcinoma2008

    • Author(s)
      Huang Y, Murakami T, Sano F, Kondo K, Nakajgawa N, Kjshida T, Kubota Y, Nagashima Y, Yao M
    • Journal Title

      Eur Urd Epub

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A three-gene expression signature model to predict dinical outcome of dear cel renal carcinoma2008

    • Author(s)
      Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
    • Journal Title

      Int J Cancer 123

      Pages: 1126-1132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma2007

    • Author(s)
      Murakami T, Sano F, Huang Y, Komiya A, Baba M, Osada Y, Nagashima Y, Kondo K, Nakaigawa N, Miura T, Kubota Y, Yao M, Kishida T
    • Journal Title

      J Pathol 211

      Pages: 524-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High FDG uptakeon oncocytoma located in the retroperitoneum mimicking malignancy2007

    • Author(s)
      Minamimoto R, Yamanaka S, Kawamoto M, Endoh M, Nishito R, Yoshida K, Nakaigawa N, Yao M, Kubota Y, Inoue T
    • Journal Title

      Clin Nucl Med 32

      Pages: 582-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of adipose differentiation-related protein : a predictor of cancer-specific survival in clear cell renal carcinoma2007

    • Author(s)
      Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Nakaigawa N, Kishida T, Nagashima Y, Kubota Y
    • Journal Title

      Clin Cancer Res 13

      Pages: 152-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小径腎癌に対するマイクロ波組織凝固装置使用、無阻血、後腹膜鏡下腎部分切除術の検討2007

    • Author(s)
      槙山和秀, 中井川昇, 三好康秀, 村上貴之, 矢尾正祐, 窪田吉信
    • Journal Title

      Jpn J Endourol ESWL 20

      Pages: 84-88

    • NAID

      10027164645

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinguishing splenosis from local recurrence of renal cell carcinoma using a technetium sulfur colloid scan2007

    • Author(s)
      Umemoto S, Miyoshi Y, Nakaigawa N, Yao M, Takebayashi S, Kubota Y
    • Journal Title

      Int J Urol. 14

      Pages: 254-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Collecting duct carcinoma producing granulocyte-colony-stimulating factor (G-CSF)2007

    • Author(s)
      Sugiura S, Makiyama K, Nakaigawa N, Yao M, Kubota Y, Oshiro H
    • Journal Title

      Int J Urol. 14

      Pages: 555-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma.2007

    • Author(s)
      Murakami T
    • Journal Title

      J Pathol. 211

      Pages: 524-31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High FDG uptake on oncocytoma located in the retroperitoneum mimicking malignancy.2007

    • Author(s)
      Minamimoto R
    • Journal Title

      Clin Nucl Med 32

      Pages: 582-3

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy Keystone symposia Steamboat 2008 March2008

    • Author(s)
      Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
    • Related Report
      2008 Final Research Report
  • [Presentation] MET蛋白シグナルを標的とした腎細胞癌に対する新規治療の検討2008

    • Author(s)
      中井川昇, 佐野太, 和田朋子, 岸田健, 矢尾正祐, 窪田吉信
    • Organizer
      弟96回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy AACR2008

    • Author(s)
      Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
    • Organizer
      99^<th> Annual Meeting
    • Place of Presentation
      SanDiego
    • Related Report
      2008 Final Research Report
  • [Presentation] パネルディスカッション99症例より学ぶ腎がん集合間症例と骨転移を伴う症例2008

    • Author(s)
      中井川昇
    • Organizer
      第73回日本泌尿器科学会東部総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy2008

    • Author(s)
      Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy2008

    • Author(s)
      Nakaigawa N, WadaT, Ishiguro H Sano F, Yao M, Kubota Y, Christensen JG
    • Organizer
      AACR 99^<th> Annual Meeting
    • Place of Presentation
      SanDiego
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎癌細胞の増殖シグナルを標的とした新規治療法の開発.2007

    • Author(s)
      中井川昇
    • Organizer
      第45回日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 分子標的治療時代におけるサイトカイン療法2007

    • Author(s)
      中井川昇
    • Organizer
      第95回日本泌尿器科学会総会教育セミナー
    • Related Report
      2008 Final Research Report
  • [Book] RCC発生のメカニズム Year Book of RCC 20082008

    • Author(s)
      矢尾正祐, 中井川昇
    • Publisher
      メディカルレビュー社
    • Related Report
      2008 Final Research Report
  • [Book] 新しい診断と治療のABC-腎癌・膀胱癌腎癌病因特に分子腫瘍学について2007

    • Author(s)
      矢尾正祐, 中井川昇, 岸田健
    • Publisher
      気原和徳最新医学社
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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