Development of the novel therapies targeting oncogenic signals of renal cell carcinoma
Project/Area Number |
19591864
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Yokohama City University |
Principal Investigator |
NAKAIGAWA Noboru Yokohama City University, 附属病院, 准教授 (00237207)
|
Co-Investigator(Kenkyū-buntansha) |
YAO Masahiro 横浜市立大学, 医学研究科, 准教授 (00260787)
KISHIDA Takeshi 横浜市立大学, 附属病院, 准教授 (60254166)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | トランスレーショナルリサーチ癌細胞 / 組織遺伝子 プロテオーム / トランスレーショナルリサーチ / 癌 / 細胞・組織 / 遺伝子 / プロテオーム |
Research Abstract |
肝細胞成長因子の受容体型チロシンキナーゼであるMET蛋白が腎細胞癌の発癌メカニズムの中で、増殖、生存能、上皮間葉転換、運動能、血管新生といった様々なstepにおいて重要な働きをしていること、このMET蛋白が腎細胞癌の新規治療標的となることを明らかにしました。
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma2008
Author(s)
Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
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Journal Title
Int J Cancer. 123(5)
Pages: 1126-32
Related Report
Peer Reviewed
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[Journal Article] A three-gene expression signature model to predict dinical outcome of dear cel renal carcinoma2008
Author(s)
Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
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Journal Title
Int J Cancer 123
Pages: 1126-1132
Related Report
Peer Reviewed
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[Journal Article] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma2007
Author(s)
Murakami T, Sano F, Huang Y, Komiya A, Baba M, Osada Y, Nagashima Y, Kondo K, Nakaigawa N, Miura T, Kubota Y, Yao M, Kishida T
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Journal Title
J Pathol 211
Pages: 524-31
Related Report
Peer Reviewed
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