Development of the novel therapies targeting oncogenic signals of renal cell carcinoma

• Project/Area Number: 19591864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: NAKAIGAWA Noboru Yokohama City University, 附属病院, 准教授 (00237207)
• Co-Investigator(Kenkyū-buntansha): YAO Masahiro 横浜市立大学, 医学研究科, 准教授 (00260787) ; KISHIDA Takeshi 横浜市立大学, 附属病院, 准教授 (60254166)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: トランスレーショナルリサーチ癌細胞 / 組織遺伝子 プロテオーム / トランスレーショナルリサーチ / 癌 / 細胞・組織 / 遺伝子 / プロテオーム

Research Abstract

肝細胞成長因子の受容体型チロシンキナーゼであるMET蛋白が腎細胞癌の発癌メカニズムの中で、増殖、生存能、上皮間葉転換、運動能、血管新生といった様々なstepにおいて重要な働きをしていること、このMET蛋白が腎細胞癌の新規治療標的となることを明らかにしました。

Research Products

• [Journal Article] Retroperitoneoscopic nephrectomy in overweight and obese Japanese patients : complications and outcomes (2008)
  • Author(s): Makiyama K, Nakaigawa N, Miyoshi Y, Murakami T, Yao M, Kubota Y.
  • Journal Title: Urol Int. 81(4) Pages: 427-30
  • Peer Reviewed
• [Journal Article] Expression of Aquaporin 1 in Primary Renal Tumors : A Prognostic Indicator for Clear-Cell Renal Cell Carcinoma (2008)
  • Author(s): Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kubota Y, Nagashima Y, Yao M
  • Journal Title: Eur Urol.
  • Peer Reviewed
• [Journal Article] Improvement on parenchymal suturing technique in laparoscopic partial nephrectomy (2008)
  • Author(s): Makiyama K, Nakaigawa N, Miyoshi Y, Murakami T, Yao M, Kubota Y.
  • Journal Title: Int J Urol 15(9) Pages: 854-5
  • NAID: 10022611700
  • Peer Reviewed
• [Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma (2008)
  • Author(s): Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
  • Journal Title: Int J Cancer. 123(5) Pages: 1126-32
  • Peer Reviewed
• [Journal Article] 非淡明細胞の臨床はどう変化する (2008)
  • Author(s): 中井川昇, 岸田健, 矢尾正祐, 窪田吉信
  • Journal Title: Urology Review 6(4) Pages: 78-84
• [Journal Article] これからはじまる進行腎がんに対する分子標的薬治療VHLを中心に (2008)
  • Author(s): 矢尾正弘, 中井川昇, 近藤慶一, 岸田健
  • Journal Title: Urology Review 6(4)
• [Journal Article] Expression of Aquaporin 1 in Primay Renal Tumors : A Prognostic Indicator for Clear-Cell Renal Cell Carcinoma (2008)
  • Author(s): Huang Y, Murakami T, Sano F, Kondo K, Nakajgawa N, Kjshida T, Kubota Y, Nagashima Y, Yao M
  • Journal Title: Eur Urd Epub
  • Peer Reviewed
• [Journal Article] A three-gene expression signature model to predict dinical outcome of dear cel renal carcinoma (2008)
  • Author(s): Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Sano F, Baba M, Kondo K, Nakaigawa N, Kishida T, Nagashima Y, Yamada-Okabe H, Kubota Y.
  • Journal Title: Int J Cancer 123 Pages: 1126-1132
  • Peer Reviewed
• [Journal Article] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma (2007)
  • Author(s): Murakami T, Sano F, Huang Y, Komiya A, Baba M, Osada Y, Nagashima Y, Kondo K, Nakaigawa N, Miura T, Kubota Y, Yao M, Kishida T
  • Journal Title: J Pathol 211 Pages: 524-31
  • Peer Reviewed
• [Journal Article] High FDG uptakeon oncocytoma located in the retroperitoneum mimicking malignancy (2007)
  • Author(s): Minamimoto R, Yamanaka S, Kawamoto M, Endoh M, Nishito R, Yoshida K, Nakaigawa N, Yao M, Kubota Y, Inoue T
  • Journal Title: Clin Nucl Med 32 Pages: 582-3
  • Peer Reviewed
• [Journal Article] Expression of adipose differentiation-related protein : a predictor of cancer-specific survival in clear cell renal carcinoma (2007)
  • Author(s): Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Nakaigawa N, Kishida T, Nagashima Y, Kubota Y
  • Journal Title: Clin Cancer Res 13 Pages: 152-60
  • Peer Reviewed
• [Journal Article] 小径腎癌に対するマイクロ波組織凝固装置使用、無阻血、後腹膜鏡下腎部分切除術の検討 (2007)
  • Author(s): 槙山和秀, 中井川昇, 三好康秀, 村上貴之, 矢尾正祐, 窪田吉信
  • Journal Title: Jpn J Endourol ESWL 20 Pages: 84-88
  • NAID: 10027164645
  • Peer Reviewed
• [Journal Article] Distinguishing splenosis from local recurrence of renal cell carcinoma using a technetium sulfur colloid scan (2007)
  • Author(s): Umemoto S, Miyoshi Y, Nakaigawa N, Yao M, Takebayashi S, Kubota Y
  • Journal Title: Int J Urol. 14 Pages: 254-7
  • Peer Reviewed
• [Journal Article] Collecting duct carcinoma producing granulocyte-colony-stimulating factor (G-CSF) (2007)
  • Author(s): Sugiura S, Makiyama K, Nakaigawa N, Yao M, Kubota Y, Oshiro H
  • Journal Title: Int J Urol. 14 Pages: 555-7
  • Peer Reviewed
• [Journal Article] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma. (2007)
  • Author(s): Murakami T
  • Journal Title: J Pathol. 211 Pages: 524-31
  • Peer Reviewed
• [Journal Article] High FDG uptake on oncocytoma located in the retroperitoneum mimicking malignancy. (2007)
  • Author(s): Minamimoto R
  • Journal Title: Clin Nucl Med 32 Pages: 582-3
  • Peer Reviewed
• [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy Keystone symposia Steamboat 2008 March (2008)
  • Author(s): Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
• [Presentation] MET蛋白シグナルを標的とした腎細胞癌に対する新規治療の検討 (2008)
  • Author(s): 中井川昇, 佐野太, 和田朋子, 岸田健, 矢尾正祐, 窪田吉信
  • Organizer: 弟96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy AACR (2008)
  • Author(s): Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
  • Organizer: 99^<th> Annual Meeting
  • Place of Presentation: SanDiego
• [Presentation] パネルディスカッション99症例より学ぶ腎がん集合間症例と骨転移を伴う症例 (2008)
  • Author(s): 中井川昇
  • Organizer: 第73回日本泌尿器科学会東部総会
  • Place of Presentation: 東京
• [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy (2008)
  • Author(s): Nakaigawa N, WadaT, Ishiguro H, Sano F, Yao M, Kubota Y , and Christensen JG
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] c-MET as a molecular target for novel clear cell renal carcinoma therapy (2008)
  • Author(s): Nakaigawa N, WadaT, Ishiguro H Sano F, Yao M, Kubota Y, Christensen JG
  • Organizer: AACR 99^<th> Annual Meeting
  • Place of Presentation: SanDiego
• [Presentation] 腎癌細胞の増殖シグナルを標的とした新規治療法の開発. (2007)
  • Author(s): 中井川昇
  • Organizer: 第45回日本癌治療学会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-25
• [Presentation] 分子標的治療時代におけるサイトカイン療法 (2007)
  • Author(s): 中井川昇
  • Organizer: 第95回日本泌尿器科学会総会教育セミナー
• [Book] RCC発生のメカニズム Year Book of RCC 2008 (2008)
  • Author(s): 矢尾正祐, 中井川昇
  • Publisher: メディカルレビュー社
• [Book] 新しい診断と治療のABC-腎癌・膀胱癌腎癌病因特に分子腫瘍学について (2007)
  • Author(s): 矢尾正祐, 中井川昇, 岸田健
  • Publisher: 気原和徳最新医学社