Analysis of the effect by angiotensin II-induced oxidative stress in the development of prostate cancer

• Project/Area Number: 19591865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: UEMURA Hiroji Yokohama City University, 附属病院・結石破砕室, 准教授 (50244439)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Yoshinobu 横浜市立大学, 大学院・医学研究科泌尿器病態学, 教授 (10106312)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 前立腺癌 / アンジオテンシン2 / 酸化ストレス / アンジオテンシン

Research Abstract

前立腺癌を含め多くの癌の発生に炎症が関わっていることが提唱されている。炎症の分子メカニズムとして酸化ストレスがあり、前立腺癌の発生や進展に酸化ストレスが関与している可能性がある。この研究では、以前より解明してきたアンジオテンシンII(Ang-II)の前立腺癌に及ぼす機能のうち、Ang-IIがもつ酸化ストレス作用に注目し、前立腺癌発生への関与の可能性について解析した。研究結果から、Ang-IIが酸化ストレスを誘発して前立腺癌の発生に関与している可能性が示唆された。

Research Products

• [Journal Article] Usefulness of the 2005 International Society of Urological Pathology Gleason Grading System in Prostate Biopsy and Radical Prostatectomy Specimens. (2009)
  • Author(s): H Uetnura. K Hoshino, T Sasaki, Y Miyoshi, H Ishiguro, YInayama, Y Kubota.
  • Journal Title: BJU Int 103 Pages: 1190-1194
  • Peer Reviewed
• [Journal Article] Epithelioid angiomyolipoma of the kidney. (2009)
  • Author(s): I Kato, Y Inayama, S Yamanaka, H Ohshiro, K Gomi, S Shirai, I Aoki, H Uemura, et al.
  • Journal Title: Pathology International 59 Pages: 38-43
  • NAID: 10027378955
  • Peer Reviewed
• [Journal Article] Angiotensin II Plays a Potential Role in Prostatic Carcinogenesis by Inducing Oxidative Stress (2008)
  • Author(s): H Uemura, H Ishiguro, Y Ishiguro, K Hoshino and Y Kubota
  • Journal Title: Mol Cancer Res. 6 Pages: 250-258
• [Journal Article] Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells (2008)
  • Author(s): J Teranishi, H Ishiguro, K Hoshino, K Noguchi, Y Kubota, H Uemura
  • Journal Title: Prostate 68 Pages: 1666-1673
• [Journal Article] Antitumor Effect of Electrochemotherapy with Bleomycin on Human Prostate Cancer Xenograft. (2008)
  • Author(s): T Ueki, H Uemura, Y Nagashima, S Ohta, H Ishiguro, Y Kubota
  • Journal Title: BJU Int. (in press)
• [Journal Article] Free PSA/ total PSA ratio increases the detection rate of prostate cancer in twelve-core biopsy (2008)
  • Author(s): Y Yokomizo, Y Miyoshi, N Nakaigawa, K Makiyama, T Ogawa, M Yao, Y Kubota, H Uemura
  • Journal Title: Urol Int (in press)
• [Journal Article] Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment (2008)
  • Author(s): H Uemura, H Ishiguro and Y Kubota
  • Journal Title: Int J Urol 15 Pages: 19-26
  • NAID: 10020179797
• [Journal Article] 前立腺癌の分子標的治療薬としてのARB、糖尿病・代謝・内分泌- (2008)
  • Author(s): 上村博司、石黒斉、窪田吉信
  • Journal Title: Annual Review Pages: 229-235
• [Journal Article] 前立腺癌に対するARBの抗腫瘍効果 (2008)
  • Author(s): 上村博司、窪田吉信
  • Journal Title: Angiotensin Research 5(1) Pages: 57-62
• [Journal Article] Angiotensin II Plays a Potential Role in Prostatic Carcinogenesis by Inducing Oxidative Stress. . 2008, : (2008)
  • Author(s): H Uemura. H Ishiguro, Y Ishiguro, K Hoshino, Y Kubota.
  • Journal Title: Mol Cancer Res 6 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Reduction of prostate motion by removal of gas in rectum during radiotherapy. (2008)
  • Author(s): Ogino I, Uemura H, Inoue T, Kubota Y, Nomura K, Okamoto N.
  • Journal Title: Int J Radiation Oncology Biol. Phys. 72 Pages: 456-466
  • Peer Reviewed
• [Journal Article] Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells., 2008, : (2008)
  • Author(s): Teranishi J, Ishiguro H, Hoshino K, Noguchi K, Kubota Y, Uemura H.
  • Journal Title: Prostate 68 Pages: 1666-1673
  • Peer Reviewed
• [Journal Article] Antitumor Effect of Electrochemotherapy with Bleomycin on Human Prostate Cancer Xenograft. . 2008, : (2008)
  • Author(s): T Ueki, H Uemura, Y Nagashima, S Ohta, H Ishiguro, Y Kubota.
  • Journal Title: BJU Int 102 Pages: 1467-71
  • Peer Reviewed
• [Journal Article] Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment. 2008, : (2008)
  • Author(s): H Uemura. H Ishiguro, Y Kubota.
  • Journal Title: Int J Urol. 15 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Angiotensin II Plays a Potential Role in Prostatic Carcinogenesis by Inducing Oxidative Stress. (2008)
  • Author(s): H Uemura, H Ishiguro, Y Ishiguro, K Hoshino and Y Kubota.
  • Journal Title: Mol Cancer Res. 6 Pages: 250-258
  • Peer Reviewed
• [Journal Article] Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment. (2008)
  • Author(s): H Uemura, H Ishiguro and Y Kubota.
  • Journal Title: Int J Urol. 15 Pages: 19-26
  • NAID: 10020179797
  • Peer Reviewed
• [Journal Article] Progress in Cancer Drug Resistance Research. (Editors : Robert A. Parsons) Nova Science Publishers (2007)
  • Author(s): H Uemura, H Ishiguro, Y Kubota
  • Journal Title: New York
• [Journal Article] Regulation of prostate cancer cell growth and PSA expression by angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma ligand like action (2007)
  • Author(s): H Ishiguro, Y Ishiguro, Y Kubota, H Uemura
  • Journal Title: Prostate 67 Pages: 924-32
• [Journal Article] Molecular targeting therapy with angiotensin II receptor blocker for prostate cancer (2007)
  • Author(s): H Uemura, H Ishiguro, Y Kubota
  • Journal Title: Oncol Rev 1 Pages: 3-13
• [Journal Article] Promotion of bladder cancer development and progression by androgen receptor signals (2007)
  • Author(s): H Miyamoto, Z Yang, YT Chen, H Ishiguro, H Uemura, Y Kubota, Y Nagashima, YJ Chang, YC Hu, MY Tsai, S Yeh, EM Messing, C Chang.
  • Journal Title: J Natl Cancer Inst. 99 Pages: 558-68
• [Journal Article] 前立腺癌におけるAR cofactorの意義 (2007)
  • Author(s): 上村博司、石黒斉、窪田吉信
  • Journal Title: 日本臨牀 65 Pages: 86-90
• [Journal Article] アンジオテンシンIIレセプターブロッカー (2007)
  • Author(s): 石黒斉、上村博司、窪田吉信
  • Journal Title: 日本臨牀 65 Pages: 142-147
• [Journal Article] ホルモン抵抗性前立腺癌の発生機序、泌尿器疾患治療の新しいストラテジー (2007)
  • Author(s): 上村博司、窪田吉信
  • Journal Title: メジカルビュー社 Pages: 102-108
• [Journal Article] 前立腺癌に対する密封小線源治療と強度変調放射線外照射の治療後QOLの比較検討 (2007)
  • Author(s): 上村博司、三好康秀、林成彦、佐野太、井口梢、伊藤悠亮、板澤朋子、荻野伊知郎、窪田吉信
  • Journal Title: 臨床泌尿器科 61 Pages: 721-728
• [Journal Article] Regulation of prostate cancer cell growth and PSA expression by angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma ligand like action (2007)
  • Author(s): H Ishiguro, Y Ishiguro, Y Kubota, H Uemura.
  • Journal Title: Prostate 67 Pages: 924-932
  • Peer Reviewed
• [Journal Article] Usefulness of the 2005 International Society of Urological Pathology Gleason Grading System in Prostate Biopsy and Radical Prostatectomy Specimens
  • Author(s): H Uemura, K Hoshino, T Sasaki, Y Miyoshi, H Ishiguro, YInayama, Y Kubota
  • Journal Title: BJU Int (in press)
• [Presentation] 前立腺癌骨転移研究について-症例中間解析- (2009)
  • Author(s): 上村博司
  • Organizer: 横浜骨転移研究会
  • Year and Date: 2009-03-27
• [Presentation] 前立腺癌、シンポジウム「PPARの臨床」 (2009)
  • Author(s): 上村博司
  • Organizer: 第9回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-24
• [Presentation] Contrast-enhanced ultrasonography of the prostate with Sonazoid, Symposium (2008)
  • Author(s): Hiroji Uemura
  • Organizer: 10th International symposium on ultrasound contrast imaging
  • Place of Presentation: 東京
  • Year and Date: 2008-12-13
• [Presentation] 酸化ストレスによる前立腺の癌化とARBの抑制効果 (2008)
  • Author(s): 上村博司
  • Organizer: 第24回前立腺シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-10
• [Presentation] 前立腺癌に対するアンジオテンシンII受容体拮抗薬の臨床応用、前立腺癌基礎から臨床へ新たな治療法の探索シンポジウム、 (2008)
  • Author(s): 上村博司
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 前立腺癌に対するアンジオテンシンII受容体措抗薬の臨床応用、前立腺癌 基礎から臨床へ 新たな治療法の探索 シンポジウム (2008)
  • Author(s): 上村博司
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Antitumor potency of angiotensin II receptor blocker for prostate cancer (2008)
  • Author(s): Hiroji Uemura
  • Organizer: 2nd World Conference on Magic Bullets (Ehrlich II)
  • Place of Presentation: Nurnberg
  • Year and Date: 2008-10-04
• [Presentation] Antitumor potency of angiotensin II receptor blocker for prostate cancer (2008)
  • Author(s): Hiroji Uemura
  • Organizer: 2nd World Conference on Magic Bullets (Ehrlich II)
  • Place of Presentation: ニュルンベルク
  • Year and Date: 2008-10-04
• [Presentation] 早期前立腺癌に対する密封小線源の再発症例についての検討 (2008)
  • Author(s): 上村博司
  • Organizer: 第73回日本泌尿器科学会東部総会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-19
• [Presentation] CHEMOPREVENTIVE ACTIVITY WITH ANGIOTENSIN II RECEPTOR BLOCKER FOR PROSTATE CANCER (2008)
  • Author(s): Hiroji Uemura
  • Organizer: UICC 08, world congress
  • Place of Presentation: Geneva
  • Year and Date: 2008-08-29
• [Presentation] CHEMOPREVENTIVE ACTIVITY WITH ANGIOTENSIN II RECEPTOR BLOCKER FOR PROSTATE CANCER (2008)
  • Author(s): Hiroji Uemura
  • Organizer: UICC 08 world congress
  • Place of Presentation: ジュネーブ
  • Year and Date: 2008-08-29
• [Presentation] 前立腺癌におけるアンジオテンシンIIIとAminopeptidase の機能解析 (2008)
  • Author(s): 上村博司
  • Organizer: 第27回分子病理研究会
  • Place of Presentation: 葉山
  • Year and Date: 2008-08-02
• [Presentation] 前立腺癌におけるアンジオテンシンIIIとAminopeptidaseの機能解析 (2008)
  • Author(s): 上村博司
  • Organizer: 第27回分子病理研究会
  • Place of Presentation: 葉山
  • Year and Date: 2008-08-02
• [Presentation] アンジオテンシンIIレセプターブロッカーによる前立腺全摘後PSA再発の延長効果 (2008)
  • Author(s): 上村博司
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-25
• [Presentation] 小線源治療 (2008)
  • Author(s): 上村博司
  • Organizer: 第6回横浜泌尿器科カンファレンス、シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-02-21
• [Presentation] Oxidative stress in prostate epithelial cells by prostate specific antigen (PSA) (2007)
  • Author(s): Uemura H
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 前立腺生検と前立腺全摘標本におけるISUP consensusのGleason scoreとclassical Gleason scoreとの比較 (2007)
  • Author(s): 上村博司
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-30
• [Presentation] 前立腺癌におけるアンジオテンシンIIレセプターブロッカーの可能性 (2007)
  • Author(s): 上村博司
  • Organizer: 第26回日本アンドロロジー学会、イブニングセミナー
  • Place of Presentation: 千葉
  • Year and Date: 2007-07-05
• [Presentation] 前立腺癌に対するホルモン耐性の分子生物学的機序とそれに基づいた治療 (2007)
  • Author(s): 上村博司
  • Organizer: 第1回Organon Framingam Forum
  • Place of Presentation: 東京
  • Year and Date: 2007-06-09
• [Presentation] 再燃前立腺癌に関わるアンドロゲン受容体とその他の因子について (2007)
  • Author(s): 上村博司
  • Organizer: 第7回関東ホルモンと癌研究会、シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-05-26
• [Presentation] 再燃前立腺癌に対するARBの作用機序と効果 (2007)
  • Author(s): 上村博司
  • Organizer: 第95回日本泌尿器科学会総会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-17
• [Book] Progress in Cancer Drug Resistance Research. (2007)
  • Author(s): Uemura H(Ed: Robert A. Parsons)
  • Total Pages: 208
  • Publisher: Nova Science Publishers