Imaging analysis in men with lower urinary tract symptoms using transrectal elastography

• Project/Area Number: 19591868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OKIHARA Koji Kyoto Prefectural University of Medicine, 医学研究科, 講師 (80285270)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Terukazu 京都府立医科大学, 医学研究科, 助教 (10381964) ; UKIMURA Osamu 京都府立医科大学, 医学研究科, 講師 (70275220) ; MIZUTANI Yoichi 京都府立医科大学, 医学研究科, 准教授 (10243031) ; KAWAUCHI Akihiro 京都府立医科大学, 医学研究科, 准教授 (90240952) ; MIKI Tsuneharu 京都府立医科大学, 医学研究科, 教授 (10243239)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: ウロダイナミクス / エラストグラフィー / 前立腺肥大症 / 経直腸的超音波断層法 / 下部尿路閉塞 / 泌尿器科学 / 組織弾性 / 下部尿路

Research Abstract

今回、前立腺尿道部の経時的な開口動態に組織学的な弾性変化をみる目的で、組織弾性イメージング機能を用いて、排尿初期から終了にいたるまでの、前立腺部尿道の弾性イメージ(ひずみ値)の対比を行った。正常症例の前立腺部尿道周囲のひずみ値(elastic grade)は、他の前立腺部の領域(辺縁域、移行域、中心域、前方繊維筋脂肪組織)と対比すると明らかに低値であった。前立腺腹側のひずみ値は、膀胱頚部からより末梢に至るまで、全般的に低値であることが観察された。前立腺肥大症のelastic gradeは、正常例と対比して、高値の部分の比率が増加し、前方繊維筋脂肪組織群に相当する部分は正常例と同様にひずみ値が低値を示していたが、腺腫部分のひずみ値はheterogenous patternを示さず、比較的層別化しており、尿道部から末梢側に移行するに従い、ひずみ値は高値を示した。以上より、排尿障害の原因の一因として、尿道部、腺腫部分のひずみ値の違いが関与していることが示唆された。

Research Products

• [Journal Article] Real-time virtual ultrasonographic radiofrequency ablation of renal cell carcinoma (2008)
  • Author(s): Ukimura O, Mitterberger M, Okihara K, Miki T, Pinggera GM, Neururer R, Peschel R, Aigner F, Gradl J, Barts Colleselli D, Strasser H, Pallwein L
  • Journal Title: Frauscher FBJU 101 Pages: 707-711
• [Journal Article] Ten year trend in prostate cancer screening with high prostate specific antigen exposure rate in Japan (2008)
  • Author(s): Okihara K, Kitamura K, Okada K, Mikami K, Ukimura O, Miki T.
  • Journal Title: Int Urol. 15 Pages: 156-160
  • NAID: 10021276771
• [Journal Article] Current trends in diagnostic and therapeutic principles for prostate cancer in Japan (2008)
  • Author(s): Okihara K, Shiraishi T, Ukimura O, Mizutani Y, Kawauchi A, Miki T.
  • Journal Title: Int J Urol. 13 Pages: 239-243
  • NAID: 10024142452
• [Journal Article] Current trends in diagnostic and therapeutic principles for prostate cancer in Japan (2008)
  • Author(s): Okihara K, et al.
  • Journal Title: Int J Oncol 13 Pages: 239-243
  • NAID: 10024142452
  • Peer Reviewed
• [Journal Article] Intraoperative ultrasonography in an era of minimallyinvasive urology. (2008)
  • Author(s): Ukimura 0, Okihara K, et al.
  • Journal Title: Int J Urol. 15 Pages: 673-680
  • Peer Reviewed
• [Journal Article] Naftopidil versus tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasla with special reference to the storage symptom : a prospective randomized control led study. (2008)
  • Author(s): Ukimura 0, Okihara K, et al.
  • Journal Title: Int J Urol. 15 Pages: 1049-1054
  • Peer Reviewed
• [Journal Article] Ten year trend in prostate cancer screening with high prostate-specific antigen exposure rate in Japan. (2008)
  • Author(s): Okihara K, et. al.
  • Journal Title: International J. Urol. 15 Pages: 156-60
  • NAID: 10021276771
  • Peer Reviewed
• [Journal Article] Clinical efficacy of alternative antiandrogen therapy in japanese men with relapsed prostate cancer after first-line hormanal therapy (2007)
  • Author(s): Okihara K, Ukimura O, Kanemitsu N, Mizutani Y, Kawauchi A, Miki T
  • Journal Title: Int J Urol. 14 Pages: 128-132
• [Journal Article] Clinical efficacy of alternative antiandrogen therapy in Japanese men with relapsed prostate cancer after first-line hormon al therapy. (2007)
  • Author(s): Okihara K, et. al.
  • Journal Title: International J. Urol. 14 Pages: 128-32
  • Peer Reviewed
• [Presentation] Real-time transrectal ultrasonography during miniraparotomy radical prostatectomy (2008)
  • Author(s): Okihara K, Ukimura O, Kanazawa M, Mizutani Y, Kawauchi A. Miki T.
  • Organizer: 26th World congress of Endourology & SWL.
  • Place of Presentation: Shanghai China
  • Year and Date: 2008-12-02
• [Presentation] Real-time transrectal ultrasonography during miniraparotomy radical prostatectomy. (2008)
  • Author(s): 0kihara K, Ukimura 0, Kanazawa M, Mizutani Y, Kawauchi A, Miki T.
  • Organizer: 26th World congress of Endourology &ESWL
  • Place of Presentation: Shanghai China
  • Year and Date: 2008-12-02
• [Presentation] Can real-time transrectal elastography in combination with power Doppler sonography enhance prostate cancer detection (2007)
  • Author(s): Okihara K, Kamoi K, Ochiai A, Ukimura O, Ushijima S, Mizutani Y, Kawauchi A, Miki T.
  • Organizer: American Urological Association, Annual meeting
  • Place of Presentation: Anaheim Ca USA.
  • Year and Date: 2007-05-23
• [Presentation] Can real-time transrectal elastography in combination with power Doppler sonography enhance prostate cancer detection? (2007)
  • Author(s): Okihara K, et. al.
  • Organizer: American Urological Association, Annual meeting
  • Place of Presentation: 米国 アナハイム