Functional analysis of angiotensin II in tumor angiogenesis of prostate cancer

• Project/Area Number: 19591869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: MIYAJIMA Akira Keio University, 医学部, 講師 (90245572)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Eiji 慶應義塾大学, 医学部, 助教 (10286552)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血管新生 / アンギオテンシンII / 受容体 / 前立腺癌 / 前立腺 / 膀胱癌 / 腎線維化

Research Abstract

ホルモン抵抗性前立腺癌にAT1R阻害剤は血管新生を抑制することで抗腫瘍効果を発揮することを証明してきたが、Angiotensin IIそのものの機能については不明である。本研究では、内分泌抵抗性を獲得するにつれAT1R発現、その下流ではVEGF発現に関連する転写因子(Ets-1,HIF-1α)の活性化が強まっていた。以上から前立腺癌内分泌抵抗性とともに血管新生が増強するメカニズムの一端を証明した。

Research Products

• [Journal Article] Angiotensin II type 1 receptor antagonist enhancescis-dichlorodiammineplatinum-enduced cytotoxicity in mouse xenograft model of bladder cancer (2009)
  • Author(s): Kosugi M, Miyajima A, Kikuchi E, Kosaka T, Horiguchi Y, Murai M, Oya M
  • Journal Title: Urology 73 Pages: 655-660
  • Peer Reviewed
• [Journal Article] Renal damage is inhibited in mice lacking the angiotensinogen gene subjected to unilateral ureteral obstruction (2009)
  • Author(s): Uchida Y, Miyajima A, Kikuchi E, Kozakai N, Kosaka T, Ieda M, Fukuda K, Ohigashi T, Oya M
  • Journal Title: Urology (in press)
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer (2009)
  • Author(s): Miyajima A, Kikuchi E, Kosaka T, Oya M
  • Journal Title: Reviews on Recent Clinical Trials (in press)
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonist enhances cis-dichlorodiammin eplatinum-enduced cytotoxicity in mouse xenograft model of bladder cancer. (2009)
  • Author(s): Kosugi M., et al.
  • Journal Title: Urology 73 Pages: 655-660
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer. Reviews on Recent Clinical Trials (2009)
  • Author(s): Miyajima A, et, al.
  • Journal Title: Reviews on Recent Clinical Trials (In press)
  • Peer Reviewed
• [Journal Article] Renal damage is inhibited in mice lacking the angiotensinogen gene subjected to unilateral ureteral obstruction (2009)
  • Author(s): Uchida A., et al.
  • Journal Title: Urology (In press)
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 antagonist enhances anti-cancer agent-induced cytotoxicity in a mice xenograft model of bladder cancer (2007)
  • Author(s): Kosugi M, Miyajima A, Kikuchi E, Horiguchi Y, Murai M
  • Journal Title: Hum cell 20 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 antagonist enhances anti-cancer agent-induced cytotoxicity in a mice xenograft model of bladder cancer (2007)
  • Author(s): Kosugi M, et. al.
  • Journal Title: Human Cell 20 Pages: 1-9
  • Peer Reviewed
• [Presentation] Ets-1 and HIF-1α induced by angiotensin II : novel new molecular targets of angiotensinII type-1 receptor blocker as an angiogenic inhibitor (2009)
  • Author(s): Kosaka T, Miyajima A, Kikuchi E, Mikami S, Shirotake S, Hasegawa M, Oya M
  • Organizer: The 105^<th> annual meeting of American Urological Association
  • Place of Presentation: Chicago
  • Year and Date: 2009-04-27
• [Presentation] AngiotensinII type I antagonist prevents hormone-refractory prostate cancer by inhibiting tumor angiogenesis (2009)
  • Author(s): Kosaka T, Miyajima A, Kikuchi E, Oya M.
  • Organizer: 24^<th> Annual European Association of Urology Congress
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2009-03-17
• [Presentation] 前立腺癌におけるAngiotensin II 1型受容体を標的とした治療の試み (2009)
  • Author(s): 城武卓、宮嶋哲、小坂威雄、菊地栄次、大家基嗣
  • Organizer: 第9回ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-24
• [Presentation] 前立腺癌におけるAngiotensin II 1型受容体を分子標的とした治療の試み (2008)
  • Author(s): 小坂威雄、宮嶋哲、菊地栄次、大家基嗣
  • Organizer: 第12回がん分子標的治療学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Book] アンジオテンシンII 1型受容体を標的とした泌尿器科癌治療の試み (2008)
  • Author(s): 宮嶋哲
  • Publisher: Angiotensin Research 5