| Project/Area Number |
19591873
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
SUZUKI Koji Kanazawa Medical University, 医学部, 教授 (70064615)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Katsuhito 金沢医科大学, 医学部, 准教授 (60219772)
MORIYAMA Manabu 金沢医科大学, 医学部, 講師 (50278131)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Thrombin / Protease-activated receptor (PAR) / Urolithiasis / Calcium oxalate / PARs / Calcium Oxalate |
|---|
| Research Abstract |
We evaluated the expression of mRNA and protein of Protease-activated receptor (PAR) as thrombin receptor in renal epithelial cells, and whether or not oxalate initiate signal transduction via this pathway. Gene and protein expression was clearly shown in HK-2 cells, which originated human tubular epithelium by PCR and Western blotting. Oxalate exposure caused up-regulation of intra-cellular calcium ion and Interleukin 6 production.
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