A study on the role of prostaglandin metabolic clearance genes in erectile function

• Project/Area Number: 19591879
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: University of Yamanashi
• Principal Investigator: NOMURA Teruhisa University of Yamanashi, 医学部・附属病院, 講師 (10252040)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Masayuki 山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: アンドロロジー / 陰茎勃起 / プロスタグランジン分解代謝系遺伝子群

Research Abstract

プロスタグランジン取り込み輸送体PGT、細胞内代謝酵素PGDH、合成酵素COX1、COX2のヒト海綿体組織における発現プロファイルを検索した。いずれも対ss-actin比10^(-2)~10^(-4)程度の強い発現を認め、陰茎、尿道、亀頭海綿体それぞれに特有の発現パターンを呈していた。プロスタノイドが海綿体機能維持に大きな役割を果たしていることを示唆するとともに、各組織における働きの違いを示すものと想定された。

Research Products

• [Journal Article] Male Voiding Dysfunction, BPH and Didactic Urological Videos 1. Modified Retropubic Open Prostatectomy Using a Vessel Sealing System (2008)
  • Author(s): Teruhisa Nomura, Makoto Kawaguchi, Takashi Yamagishi, Hiroshi Nakagomi, Masami Aikawa, Isao Araki, Masayuki Takeda
  • Journal Title: AUA/Boehringer IngelheimDVD Library 2008 Disk1 Session 1
  • Peer Reviewed
• [Journal Article] Differential impact of lower urinary tract symptoms on generic and disease-specific quality of life in men and women (2008)
  • Author(s): Isao Araki, Takayuki Tsuchida, Teruhisa Nomura, Mizuya Fukasawa, Yoshio Takihana, Nobuyuki Koyama, Masayuki Takeda
  • Journal Title: Urologia Internationalis 81 Pages: 60-65
  • Peer Reviewed
• [Journal Article] 3.α1受容体遮断薬を使用中の患者におけるLUTSとEDとの関連↓-LUTSとEDに共通する新しい薬剤の可能性-泌尿器外科 (2008)
  • Author(s): 小室三津夫、荒木勇雄、野村照久、別府正典、武田正之、藪崎昇、内山秀行
  • Journal Title: 21(臨時増刊) Pages: 275-277
  • Peer Reviewed
• [Journal Article] 山梨大学における根治的腎摘除術の術式による手術成績の比較検討と若手医師を対象に行った術式に関するアンケート調査-体腔鏡下手術とミニマム創内視鏡下手術- (2008)
  • Author(s): 座光寺秀典、野村照久、深澤瑞也、土田孝之、澤田智史、神家満学、間庭章光、三神裕紀、小林英樹、荒木勇雄、武田正之
  • Journal Title: Jpn Endourol ESWL 21 Pages: 363-368
  • NAID: 10024373067
  • Peer Reviewed
• [Journal Article] Male Voiding Dysfunction, BPH and Didactic Urological Videos 1. Modified Retropubic Open Prostatectomy Using a Vessel Sealing System (2008)
  • Author(s): Teruhlsa Nomura, Makoto Kawaguchi, Masayuki Takeda, et. al.
  • Journal Title: AUA/Boehringer Ingelheim DVD Library 2008 Diskl
  • Peer Reviewed
• [Journal Article] Differential impact of lower urinary tract symptoms on generic and disease-specifie quality of life in men and women (2008)
  • Author(s): Isao Araki, Teruhisa Nomura, Masayuki Takeda, et. al.
  • Journal Title: UROLOGIA INTERNATIONALIS 81 Pages: 60-65
  • Peer Reviewed
• [Journal Article] Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-Fiber pathway (2007)
  • Author(s): Du Shuqi, Isao Araki, Mitsuharu Yoshiyama, Teruhisa Nomura, Masayuki Takeda
  • Journal Title: Urology 70(4) Pages: 826-831
  • Peer Reviewed
• [Journal Article] Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-Fiber pathway (2007)
  • Author(s): DU SHUQI Teruhisa Nomura Masayuki Takeda, et. al.
  • Journal Title: UROLOGY 70(4) Pages: 826-831
  • Peer Reviewed
• [Presentation] Contribution of acid-sensing ionbladder response to acetic acid : A novel candidate for interstitial cystitis pathogenesis (2008)
  • Author(s): Hideki Kobayashi, Mitsuharu Yoshiyama, Isao Araki, Hidenori Zakoji, Norifumi Sawada, Noboru Yabusaki, Takayuki Tsuchida, Teruhisa Nomura, Mizuya Fukasawa, Masayuki Takeda
  • Organizer: The 3^<rd> Pan-Pacific Continence Society Meeting
  • Place of Presentation: Taiwan
  • Year and Date: 2008-09-26
• [Presentation] Laparoscopic adrenalectomy ↓ ↓ Adrenal incidentaloma (2008)
  • Author(s): Masayuki Takeda, Hidenori Zakoji, Takayuki Tsuchida, Yuuki Mikami, Takashi Yamagishi, Teruhisa Nomura, Mizuya Fukasawa, Isao Araki
  • Organizer: 11^<th> World Congress of Endoscopic Surgery
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-03
• [Presentation] High incidence of non-detected tumor(pT0)after neoadjuvant endocrine treatment and radical prostatectomy was not correlated with lower incidence of PSA recurrence in localized prostatic carcinoma in yamanashi, Japan (2008)
  • Author(s): Takashi Yamagishi, Hidenori Zakoji, Mizuya Fukasawa, Teruhisa Nomura, Takayuki Tsuchida, Yoshio Takihana, Isao Araki, Masayuki Takeda
  • Organizer: AUA 2008 annual meetin
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2008-05-20
• [Presentation] Male Voiding Dysfunction, BPH and Didactic Urological Videos 1. Modified Retropubic Open Prostatectomy Using a Vessel Sealing System (2008)
  • Author(s): Teruhisa Nomura, Makoto Kawaguchi, Takashi Yamagishi, Hiroshi Nakagomi, Masami Aikawa, Isao Araki, Masayuki Takeda
  • Organizer: AUA 2008 annual meeting
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2008-05-18
• [Presentation] Efficacy and safety of paclitaxel and gemcitabine combination as the chemotherapy for advanced/mrtastatic urothelial cancer in a single center in japan (2008)
  • Author(s): Akihiro Maniwa, Manabu Kamiyama, Yuuki Mikami, Yasuhisa Furuya, Hidenori Zakoji, Takayuki Tsuchida, Teruhisa Nomura, Mizuya Fukasawa, Yoshio Takihana, Isao Araki, Masayuki Takeda
  • Organizer: AUA 2008 annual meeting
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2008-05-18
• [Presentation] 腎腫瘍に対する腎部分切除術の検討-開放手術・体腔鏡下手術・ミニマム創手術の比較- (2008)
  • Author(s): 萱沼賢司、野村照久、山岸敬、間庭章光、三神裕紀、座光寺秀典、土田孝之、深澤瑞也、荒木勇雄、武田正之
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-27
• [Presentation] ヒト前立腺癌におけるprostaglandin分解代謝系遺伝子発現異常の検討 (2008)
  • Author(s): 野村照久, 間庭章光, 萱沼賢司, 山岸敬, 武田正之
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-25
• [Presentation] ミニマム創内視鏡下前立腺全摘除術における両行性アプローチの改良 (2008)
  • Author(s): 野村照久、間庭章光、三神裕紀、山岸敬、羽根田破、萱沼賢司、荒木勇雄、武田正之
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-25
• [Presentation] ヒト膀胱および前立腺における温度感受性イオンチャネル(TRPA1とTRPM8)の発現様式とBOO/BPHによる発現変化 (2008)
  • Author(s): 荒木勇雄、都書、姜元軍、澤田智史、望月勉、小林英樹、野村照久、武田正之
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-25
• [Presentation] Modified Retropubic Open Prostatectomy Using a Vessel Sealing System (2008)
  • Author(s): Teruhisa Nomura, Makoto Kawaguchi, et. al.
  • Organizer: An annual meeting of American Urologic al Association
  • Place of Presentation: Orlando, florida USA
• [Presentation] High incidence of non-detected tumor (pT0) after neoadjuvant endocrine treatment and radical prostatectomy was not correlated with lower incidence of psa recurrence in localized prostatic carcinoma in yamanashi, Japan (2008)
  • Author(s): Takashi Yamagishi, Teruhisa Nomura, Masayuki Takeda, et. al.
  • Organizer: An annuaal meeting of American Urological Association
  • Place of Presentation: Orlando, florida USA
• [Presentation] Efficacy and safety of paclitaxel and gemcitabine combi nation as the chemotherapy for advanced/ mrtastatic urothelial caner in a single center in japan (2008)
  • Author(s): Akihiro Maniwa, Teruhisa Nomura, Masayuki Takeda, et. al.
  • Organizer: An annuaal meeting of American Urological Association
  • Place of Presentation: Orlando, florida USA
• [Presentation] A questionnaire-based survey of opinions about radical nephrectomy among young urologists at University of Yamanashi (2007)
  • Author(s): Hidenori Zakoji, Teruhisa Nomura, Takayuki Tsuchida, Mizuya Fukasawa, Yuuki Mikami, Akimitsu Maniwa, Isao Araki, Masayuki Takeda
  • Organizer: 第21回日本endourology・ESWL学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-28
• [Presentation] Comparison of laparoscopic surgery and portless endoscopic surgery for renal cell cancer at University of Yamanashi (2007)
  • Author(s): Hidenori Zakoji, Teruhisa Nomura, Takayuki Tsuchida, Mizuya Fukasawa, Yuuki Mikami, Akimitsu Maniwa, Isao Araki, Masayuki Takeda
  • Organizer: 第21回日本endourology・ESWL学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-28
• [Presentation] Expression profiles of prostaglandin E2 receptor subtypes in human bladder mucosa with bladder outlet obstruction (2007)
  • Author(s): Jiang Yuan Jun, Hideki Kobayashi, Norifumi Sawada, Mitsuharu Yoshiyama, Hidenori Zakoji, Teruhisa Nomura, Mizuya Fukasawa, Isao Araki, Masayuki Takeda
  • Organizer: The 2^<nd> Pan-Pacific continence society meeting
  • Place of Presentation: soul, Korea
  • Year and Date: 2007-10-19
• [Presentation] Expression profiles of prostaglandin E2 receptor subtypes in human bladder mucosa with bladder outlet obstruction (2007)
  • Author(s): Jiang Yuan Jun Hideki Kobayashi Norifumi SAWADA Mitsuharu Yoshiyama Hidenori Zakoji Teruhisa Nomura
  • Organizer: The 2nd Pan-Pacific continence society meeting
  • Place of Presentation: seoul, Korea
  • Year and Date: 2007-10-19
• [Presentation] ベッセルシーリングシステムLigaSure TM Xtdを用いた恥骨後式前立腺皮膜下摘除術の工夫 (2007)
  • Author(s): 野村照久、川口真琴、山岸敬、羽根田破、間庭章光、荒木勇雄、武田正之、相川雅美、中込宙史、寺本咲子、滝花義男
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-30
• [Presentation] Expression profiles of prostaglandin E2 receptor subtypes in human bladder mucosa with bladder outlet obstruction (2007)
  • Author(s): Hideki Kobayashi, Isao Araki, Hidenori Zakoji, Du Shuqi, Norifumi Sawada, Tsutomu Mochizuki, Mitsuharu Yoshiyama, Takayuki Tsuchida, Teruhisa Nomura, Mizuya Fukasawa, Yoshio Takihana, Masayuki Takeda
  • Organizer: 37^<th> ICS 2007
  • Place of Presentation: Rotterdam, The Netherlands
  • Year and Date: 2007-08-22
• [Presentation] Agonists of transient receptor potential channel a1 cause hyper-reflexic micturition by affecting bladder afferent activity in rats (2007)
  • Author(s): Du Shuqi, Isao Araki, Teruhisa Nomura, Mitsuharu Yoshiyama, Masayuki Takeda
  • Organizer: AUA 2007 annual meeting
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2007-05-21
• [Presentation] ミニマム創内視鏡下前立腺全摘除術の工夫 (2007)
  • Author(s): 野村照久、中込宙史、川口真琴、三神裕紀、間庭章光、望月勉、高木孝治、澤田智史、石川覚之、荒木勇雄、武田正之
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-16
• [Presentation] ミニマム創内視鏡下前立腺全摘除術-逆行性アプローチと順行性アプローチの比較検討 (2007)
  • Author(s): 川口真琴、野村照久、高木孝治、石川覚之、中込宙史、間庭章光、三神裕紀、澤田智史、土田孝之、深澤瑞也、滝花義男、荒木勇雄、武田正之
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-15