| Project/Area Number |
19591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
MIYAMOTO Toshinobu Asahikawa Medical College, 医学部, 助教 (70360998)
|
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| Co-Investigator(Kenkyū-buntansha) |
SENGOKU Kazuo 旭川医科大学, 医学部, 教授 (30163124)
石川 睦男 旭川医科大学, 医学部, 副学長 (20002131)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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|---|
| Keywords | azoospermia / mutation / SNP / spermatogenesis / meiosis / PARP-2 / SPATA17 / 無精子症 / 不妊症 / 遺伝子 / 生殖医学 / 減数分裂 / MEISETZ / HOP2 / CDK2 |
|---|
| Research Abstract |
One of the most serious social problems facing Japan today is the declining birth rate. However, it is generally not well recognized that the number of infertile couples is on the rise in advanced nations. One of the most serious causes for infertility is male factor. Therefore, we analyzed the genes causing human azoospermia, especially meiosis. It was suggested that the human MEISETZ, PARP-2 and SPATA17 play critical roles in spermatogenesis, especially meiosis.
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