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Oocyte-Granulosa-Theca Cell Interactions during Preantral Follicular Development : A translational research for the selection of the best quality oocytes in assisted reproduction

Research Project

Project/Area Number 19591892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Fukui

Principal Investigator

ORISAKA Makoto  University of Fukui, 医学部・附属病院, 講師 (80324143)

Co-Investigator(Kenkyū-buntansha) FUKUDA Shin  福井大学, 医学部, 助教 (40397279)
TAJIMA Kimihisa  福井大学, 医学部・附属病院, 講師 (60303377)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生殖医学 / 体外受精 / 卵胞発育 / 卵胞閉鎖 / 卵子 / GDF-9 / アンドロゲン / アポトーシス / 不妊症 / 卵胞
Research Abstract

早期の卵胞(前胞状卵胞)において、卵子由来のGDF-9は、(1)莢膜細胞のアンドロゲン産生促進、および(2)顆粒膜細胞のアポトーシス抑制を介して、卵胞発育を促進するメカニズムが、明らかになった。このように、GDF-9が卵胞の生存や発育に極めて重要な物質であることから、卵子に発現するGDF-9の量、あるいはGDF-9によって制御されている様々な物質を調べることにより、卵子の質を評価できる可能性が推測された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis2009

    • Author(s)
      Orisaka M, Jiang JY, Orisaka S, Kotsuji F, Tsang BK
    • Journal Title

      Endocrinology 150(6)

      Pages: 2740-2748

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth Differentiation Factor 9 Promotes Rat Preantral Follicle Growth by Up-regulating Follicular Androgen Biosynthesis.2009

    • Author(s)
      Orisaka M
    • Journal Title

      Endocrinology (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovarian theca cells in follicular function2007

    • Author(s)
      Tajima K, Orisaka M, Mori T, Kotsuji F
    • Journal Title

      Reprod Biomed Online 15(5)

      Pages: 591-609

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin and intra-ovarian signals regulating follicle development and atresia : the delicate balance between life and death2007

    • Author(s)
      Craig J, Orisaka M, Wang H, Orisaka S, Thompson W, Zhu C, Kotsuji F, Tsang BK
    • Journal Title

      Front Biosci 12

      Pages: 3628-3639

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis2009

    • Author(s)
      Orisaka M, Tsang BK, Kotsuji F
    • Organizer
      42nd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Pittsburgh, Pennsylvania, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵特異的成長因子GDF-9による前胞状卵胞の促進メカニズム2008

    • Author(s)
      折坂誠
    • Organizer
      第60回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 卵特異的成長因子GDF-9による前胞状卵胞の発育促進メカニズム2008

    • Author(s)
      折坂誠, 折坂早苗, 福田真, 田嶋公久, 吉田好雄, 小辻文和
    • Organizer
      第60回日本産科婦人科学会総会並びに学術講演会
    • Place of Presentation
      横浜市
    • Related Report
      2008 Final Research Report
  • [Presentation] GDF-9はアンドロゲン産生を介して前胞状卵胞の発育を促進する2007

    • Author(s)
      折坂 誠
    • Organizer
      第52回日本生殖医学会
    • Place of Presentation
      秋田
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Growth Differentiation Factor-9(GDF-9)はアンドロゲン産生を介して前胞状卵胞の発育を促進する2007

    • Author(s)
      折坂誠, 福田真, 田嶋公久, 小辻文和
    • Organizer
      第52回日本生殖医学会総会・学術講演会
    • Place of Presentation
      秋田市
    • Related Report
      2008 Final Research Report
  • [Presentation] GDF9 is antiapoptotic during follicular development from preantral to early antral stage2007

    • Author(s)
      Orisaka M
    • Organizer
      The 4^<th> Canada-Japan Bilateral Workshop on Human Reproduction & Reproductive Biology
    • Place of Presentation
      弘前市
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵による卵胞発育・閉鎖調節機構の研究~Growth DifferentiationFactor-9は前胞状卵胞の閉鎖を抑制し発育を促す~2007

    • Author(s)
      折坂誠, 折坂早苗, 福田真, 田嶋公久, 小辻文和
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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