Genetic polymorphisms of cytokines and their receptors Susceptibility to endometriosis

• Project/Area Number: 19591903
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KITAWAKI Jo Kyoto Prefectural University of Medicine, 医学研究科, 教授 (00204925)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 子宮内膜症 / 遺伝子多型 / サイトカイン / HLA / Klller irllmunoglobulirhke receptor / Killer immunoglobulin-like receptor

Research Abstract

子宮内膜症は、多遺伝子性の素因のもとに環境因子が加わつて発生する慢性炎症性疾患である。natural killer (NK)細胞の機能低下が本疾患の病態と関連する。killer immunoglobulin-like receptor(KIR)はNK細胞表面に発現し、標的細胞のHLAクラスI分子を認識する。KIRと対応するHLAリガンドとの組み合わせで分析すると、活性化遺伝子型群の頻度が対照と比較して内膜症群で有意に少なく、かつ抑制性遺伝子型群の頻度が内膜症群で有意に多かった。KIRの遺伝子多型が子宮内膜症の疾患感受性に関連している可能性が示唆された。

Research Products

• [Journal Article] 子宮内膜症性嚢胞由来卵巣癌におけるPTEN 遺伝子のloss ofheterozygosity(LOH), 癌関連遺伝子変異, およびタンパク発現 (2009)
  • Author(s): 徐沐, 北脇城, 石原広章, 預田新七, 楠木泉, 伊藤良治, 中田好則, 本庄英雄
  • Journal Title: エンドメトリオーシス研究会会誌 29 Pages: 94-96
• [Journal Article] Effects of estrogens on cholinergic neurons in the rat basal nucleus (2009)
  • Author(s): Yamamoto H, Kitawaki J, Kikuchi N, Okubo T, Iwasa K, Kawata M, Honjo H
  • Journal Title: J Steroid Biochem Mol Blol 107 Pages: 70-79
  • Peer Reviewed
• [Journal Article] Maintenance therapy involving a tapering dose of danazol or mid/1ow doses Of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain (2008)
  • Author(s): Kitawaki J, IShihara H, Kiyomizu M, Honjo H.
  • Journal Title: Fertil Steril 89 Pages: 183-1835
  • Peer Reviewed
• [Journal Article] Supplementation of hydrogen- rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance (2008)
  • Author(s): Kajiyama S, Hasegawa C, Asano M,Hosoda H, Fukui M, Nakamura N,Kitawaki J, Imai s, Nakano K, Ohta M,Adachi T, Obayashi H, Yoshikawa T.
  • Journal Title: Nutr Res 28 Pages: 137-143
• [Journal Article] Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain (2008)
  • Author(s): Kitawaki J, et al.
  • Journal Title: Fertility and Sterility 89 Pages: 1831-1835
  • Peer Reviewed
• [Journal Article] 子宮内膜症性嚢胞由来卵巣癌におけるPTEN遺伝子のloss of heterozygosity (LOH), 癌関連遺伝子変異, およびタンパク発現 (2008)
  • Author(s): 徐 冰, 他
  • Journal Title: エンドメトリオーシス研究会会誌 29 Pages: 94-96
• [Journal Article] Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis (2007)
  • Author(s): Kitawaki J, Xu B, Ishihara H, Fukui M, Hasegawa C, Nakamura N, Mizuno S, Ohta M, Obayashi O, Honjo H.
  • Journal Title: Am J Reprod lmmunol 58 Pages: 481-486
  • Peer Reviewed
• [Journal Article] Differential effects of progestogens, by type and regimen (2007)
  • Author(s): XuB,Kitawaki J,Koshiba H,Ishihara H, Kiyomizu M, Teramoto M, Kitaoka Y, Honjo H.
  • Journal Title: on estrogen-metabolizing enzymes in human breast cancer cells 56 Pages: 142-152
  • Peer Reviewed
• [Journal Article] Differential effects of progestogens, by type and regimen, on estrogen-metabolizing enzymes in human breast cancer cells (2007)
  • Author(s): Xu B, Kitawaki J, Koshiba H, Ishihara H, Kiyomizu M, Teramoto M, Kitaoka Y, Honjo H
  • Journal Title: Maturitas 56 Pages: 142-152
  • Peer Reviewed
• [Journal Article] Effects of estrogens on cholinergic neurons in the rat basal nucleus (2007)
  • Author(s): Yamamoto H, Kitawaki J, Kikuchi N, Okubo T, Iwasa K, Kawata M, Honjo H
  • Journal Title: J Steroid Biochem Mol Biol 107 Pages: 70-79
  • Peer Reviewed
• [Journal Article] Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis (2007)
  • Author(s): Kitawaki J, Xu B, Ishihara H, Fukui M, Hasegawa G, Nakamura N, Mizuno S, Ohta M, Obayashi O, Honjo H
  • Journal Title: Am J Reprod Immunol 58 Pages: 481-486
  • Peer Reviewed
• [Presentation] Management of endometriosisi Surgical treatment? Medical therapy? (2008)
  • Author(s): Kitawaki J.
  • Organizer: 110th Anniversary of the Affiliated Hospital of the Medical College of Qingdao University
  • Place of Presentation: 中国、青島市
  • Year and Date: 2008-10-15
• [Presentation] Management of endometriosis : Surgical treatment? Medical therapy? (2008)
  • Author(s): Kitawaki J
  • Organizer: 11Oth Anniversary of the Affiliated Hospital of the Medical College of Qingdao University
  • Place of Presentation: 青島市, 中国
  • Year and Date: 2008-10-15
• [Presentation] Klller cell illmunoglobulin-like receptor genotypes and human leukocyte antigen class I/II alleles in endometriosis susceptibllity (2008)
  • Author(s): Kitawaki J, Xu B, HonJo H
  • Organizer: 10th World Congress on Endometriosis
  • Place of Presentation: オーストラリア、メルボルン
  • Year and Date: 2008-03-12
• [Presentation] Killer cell immunoglobulin-like receptor genotypes and human leukocyte antigen class I/II alleles in endometriosis susceptibility (2008)
  • Author(s): Kitawaki J, Xu B, Honjo H
  • Organizer: 10th World Congress on Endometriosis
  • Place of Presentation: オーストラリア国、メルボルン市
  • Year and Date: 2008-03-12
• [Presentation] Changes ln the expresslon of steroid-associated and apoptosis- associated prOteins during malignant transformatlon of ovarlan edometriosis (2007)
  • Author(s): Kusuki I, Kitawaki J, Kiyomizu M,Ishihara H, Itoh R, Nakata Y, Honjo H.
  • Organizer: The XXth Asian and Oceanic Congress of Obstetrlcs and Gynecology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-24
• [Presentation] IL-6-634C/G and ICAM-1 469K/E polymorphisms on the susceptibility for endometriosis inJ apanese women (2007)
  • Author(s): Kiyomizu M, Kitawaki J, IShihara H, Honjo H.
  • Organizer: The XXth Asian and Oceanlc Congress of Obstetrlcs and Cynecology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-22
• [Book] Chapter 7 : Immunogenic HLA class I epitopes identified by humoral response to pregnancies. In : Terasaki PI, editor. Clinical Transplants 2008 (2009)
  • Author(s): Maruya E, et al.
  • Publisher: Terasaki Foundation Laboratory
• [Book] Chapter 7 : ImmunOgenic HLA class I epitopes identified by humoral response to pregnancies (2008)
  • Author(s): Maruya E, Sasaki N, EI-Awar N, Akaza T, Kitawaki J, Sajl H, TerasakI PI.
  • Publisher: In : Terasaki PI, editor. Clinical Transplants 2008. Terasaki Foundatlon Laboratory, Los Angelest
• [Book] Chapter 7 : HLA class l epitopesi C-10cus. In : Terasaki PI, editor. Clinical Transplants 2006. (2007)
  • Author(s): Akaza T, El-Awar N, Nguyen A, Kitawaki I, Terasaki PI.
  • Publisher: Terasaki Foundatlon Laboratory, Los Angeles