| Project/Area Number |
19591921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Kiyoshi Tohoku University, 大学院・医学系研究科, 准教授 (70241594)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Satoshi 東北大学, 病院, 臨床検査技師 (40420020)
ABE Keiko 東北大学, 未来医工学治療開発センター, 臨床検査技師 (30444003)
SUZUKI Fumihiko 東北大学, 大学院・医学系研究科, 助教 (20400343)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Peroxisome Proliferator-Activated Receptor (PPAR) / 子宮内膜癌 / メタボリックシンドローム / PPAR活性剤 / アロマターゼ / レチノイド / 癌-間質相互作用 / コーヒー / Peroxisome Proliferator-Activated Receptor(PPAR) / Metabolic Syndrome / Aromatase / Green Tea / Coffee / Retinoid / Retinoic acid receptor (RAR) |
|---|
| Research Abstract |
The inspection from the viewpoint of metabolic syndrome is useful for the sorting of the endometrial cancer risk. In addition, PPARγ ligands, known as the metabolic syndrome therapeutic drugs, and the agonists of retinoid receptors forming heterodimerization with PPAR, should be important drug candidates for endocrine treatment of endometrial cancer. On the other hand, we indicated aromatase played a very important role in the local biosynthesis of estrogen in human endometrial cancer through tumor-stromal cell interactions. Therefore, aromatase inhibitors should be useful drugs especially for patients with endometrial cancers, which have aromatase activities.
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