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The role of laminin peptides for acquirement of metastasis of the free floating of ovarian cancer spheroids

Research Project

Project/Area Number 19591928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Fukui

Principal Investigator

YOSHIDA Yoshio  University of Fukui, 医学部, 准教授 (60220688)

Co-Investigator(Kenkyū-buntansha) SAWAMURA Yoko  福井大学, 医学部・産婦人科, 助教 (40436845)
SHINAGAWA Akiko  福井大学, 医学部・産婦人科, 助教 (90444223)
Research Collaborator HYNDA H  Kleinmann, NIH, 教授
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords卵巣がん / laminin peptide syndecan-1 cisplatin / 浮遊増殖細胞 / 分子治療開発 / 分子標的
Research Abstract

AG73T laminin peptideはシスプラチンの作用を増強し、卵巣がんの新たな治療法になる可能性がある

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin2008

    • Author(s)
      Yoshida Y, Kurokawa T, Nishikawa Y, Orisa M, Kleinman HK, Kotsuji F
    • Journal Title

      Int J Oncol 32(3)

      Pages: 673-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin2008

    • Author(s)
      Yoshda Y tetuji kurokawa Yukiko nishikawa makoto Orisaka hynda k kleinmann Fumikazu kotsuji
    • Journal Title

      Int. J. Oncology 32

      Pages: 673-681

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin2008

    • Author(s)
      Yoshida Yoshio, et. al.
    • Journal Title

      Int. J. Oncol 32

      Pages: 673-681

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hynda K Kleinmann A potent peptide antagonist to an active laminin-1 sequence and cisplatin synergize in down regulation of Bcl-2/Bax ratios induction of apoptosis in human ovarian cancer cells2008

    • Author(s)
      Yoshida Y, Kurokawa T, Kotsuji F
    • Organizer
      13 World Congress on Advances in Oncology
    • Place of Presentation
      Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Hynda K Kleinmann Laminin-1 derived AG73 peptides inhibited formation of multicellular spheroids of free-floating ovarian cancer cells2007

    • Author(s)
      Yoshida Y, Yagihara A, Kurokawa T, Kotsuji F
    • Organizer
      Proceedings of American
    • Place of Presentation
      USA
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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