Functional analysis of lipocalin 2 overexpression in endometrial carcinoma

• Project/Area Number: 19591929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Shinshu University
• Principal Investigator: SHIOZAWA Tanri Shinshu University, 医学部, 教授 (20235493)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Tsutomu 信州大学, 医学部・附属病院, 助教 (70418721) ; IKUO Konishi 信州大学, 医学部, 教授 (90192062)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 子宮内膜癌 / lipocalin2 / 増殖 / lipocalin 2

Research Abstract

子宮内膜癌の発生に関与する遺伝子変異を同定する目的で、正常および腫瘍性内膜組織に発現する遺伝子をマイクロアレイ解析で探索したところ、内膜癌で過剰発現している分子として従来鉄イオンの運搬に関与するとされているlipocalin2を同定した。今回の検討によってlipocalin2の過剰発現が内膜癌の増殖能と転移能の亢進に関与していることが新たに明らかとなり、lipocalin2が内膜癌に対する分子標的となりうる可能性が示唆された。

Research Products

• [Journal Article] Up-regulation of nuclear receptor corepressor(NCoR)by proges tins is associated with growth suppression of endometrial neoplasia (2009)
  • Author(s): Kashima H, Miyamoto T, Shioz awa T, et.al.(他5名)
  • Journal Title: Implication for the me chanism of progestin effect in the hormone-re sponsive neoplasia Anti-Cancer Research (in press)
  • Peer Reviewed
• [Journal Article] Autocrine stimula tion of IGF1 in estrogen-induced growth ofe ndometrial carcinoma cells: involvement of the mitogen activated proteinkinase pathway foll owed by up-regulation of cyclin D1 and cyclin E (2009)
  • Author(s): Kashima H, Shiozawa T Miya moto T, et.al.(他4名)
  • Journal Title: Endocrine Related Cancer 16(1) Pages: 113-122
  • Peer Reviewed
• [Journal Article] Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells : involvement of the mitogen-activated proteinkinase pathway followed by up-regulation of cyclin D1 and cyclin E. (2009)
  • Author(s): Kashima H, Miyamoto T, Shiozawa T, et al.
  • Journal Title: Endocrine Related Cancer Marl6(1) Pages: 113-122
  • Peer Reviewed
• [Journal Article] Up-regulation of nuclear receptor corepressor (NCoR)by progestins is associated with growth suppression of endometrial neoplasia : Impllcation for the mechanism of progestin effect in the hormone responsive neoplasia (2009)
  • Author(s): Kashima H, Miyamoto T, Shiozawa T, et al.
  • Journal Title: Anti-Cancer Research (In press)
  • Peer Reviewed
• [Journal Article] Estrogen and Endometrial Carcinoma: A New Perspective(Review) (2007)
  • Author(s): Shiozawa T, et. al.
  • Journal Title: Trends in Cancer Research 3 Pages: 15-26
• [Presentation] 他子宮内膜癌化に関わる遺伝子の検索の試 (2008)
  • Author(s): 宮本強、塩沢丹里
  • Organizer: Lipocalin2の発現と機能第40回臨床分子形態学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-10-04
• [Presentation] 子宮内膜癌化に関わる遺伝子の検索の試み : Lipocalin 2 の発現と機能 (2008)
  • Author(s): 宮本強, 塩沢丹里, 他
  • Organizer: 第40回臨床分子形態学会(シンポジウム)
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2008-10-04
• [Presentation] ほか子宮内膜癌化に関わる遺伝子の検索の試み (2007)
  • Author(s): 宮本強
  • Organizer: Lipocalin2の発現と機能第6回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2007-07-21
• [Presentation] 子宮内膜癌化に関わる遺伝子の検索の試み:Lipocalin2の発現と機能 (2007)
  • Author(s): 宮本強、ほか
  • Organizer: 第6回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 熊本 阿蘇プリンスホテル
  • Year and Date: 2007-07-21