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Activated local immunity by chemokine CCL19-transfected embryonic endothelial progenitor cells suppresses metastasis of murine ovarian cancer

Research Project

Project/Area Number 19591932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

MANDAI Masaki  Kyoto University, 医学研究科, 講師 (80283597)

Co-Investigator(Kenkyū-buntansha) FUKUHARA Ken  京都大学, 医学研究科, 講師 (00362533)
YAGI Haruhiko  京都大学, 医学研究科, 助教 (70402857)
SUZUKI Ayako  京都大学, 医学研究科, 助教 (90378696)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords婦人科腫瘍学 / 腫瘍免疫 / 卵巣癌 / 免疫療法 / 転移 / 血管内皮前駆細胞 / 婦人科腫瘍 / ケモカイン / 遺伝子導入 / 卵巣癌細胞 / 肺転移 / 腫瘍血管
Research Abstract

本研究は卵巣癌の転移巣や播種巣において、局所における腫瘍の免疫環境を積極的に改善することで免疫療法の効果を高めることを目的としている。近年、腫瘍において末梢中の血管内皮前駆細胞が取り込まれて血管新生に利用されていることが知られてきているが、我々はこれをキャリアとして利用し、免疫活性化因子を導入し病巣にターゲティングすることで、効果的に局所の腫瘍免疫を活性化するという新しい免疫標的治療のモデルを開発した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2009 2008 2007 2006

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (14 results)

  • [Journal Article] Classification using hierarchical clustering of tumor infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression2009

    • Author(s)
      Liu M, Matsumura N, Mandai M, et.al.
    • Journal Title

      Mod Pathol 22(3)

      Pages: 373-84

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer2009

    • Author(s)
      Li K, Mandai M, Hamanishi J, et.al.
    • Journal Title

      Cancer Immunol Immunother 58(5)

      Pages: 641-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer.2008

    • Author(s)
      Li K, Mandai M, Hamanishi J, et al.
    • Journal Title

      Cancer Immunol Immunother.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression.2008

    • Author(s)
      Liu M, Matsumura N, Mandai M, et al.
    • Journal Title

      Mod Pathol.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunostimulatory effect of Fms-like tyrosine kinase 3 ligand on peripheral monocyte-derived dendritic cells2008

    • Author(s)
      Matsumura N, Mandai M, Hamanishi J, Yamaguchi K, Fukuhara K, Yagi
    • Journal Title

      Oncol Rep. 19

      Pages: 505-15

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.2007

    • Author(s)
      Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E,
    • Journal Title

      Biochem Biophys Res Commun. 360

      Pages: 363-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition.2007

    • Author(s)
      Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E,
    • Journal Title

      Gynecol Oncol 105

      Pages: 703-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 卵巣癌腹膜播種の新生血管を標的として、ケモカイン遺伝子(CCL19)導入胚性血管内皮前駆細胞を用いて局所免疫賦活を目指した新規免疫療法開発の基礎的検討2009

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾、小西郁生
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Activated local immunity by chemokine CCL19-transduced embryonic endothelial progenitor cells suppresses lung metastasis of murine ovarian cancer2009

    • Author(s)
      Hamanishi J, Mandai M, Higuchi T, Yamaguchi K, Takakura K, Fujii S, Konishi I
    • Organizer
      40th Annual Meeting of Women's Cancer
    • Place of Presentation
      San Antonio, Texas
    • Year and Date
      2009-02-06
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 卵巣癌の新生血管を標的としてケモカイン遺伝子(CCL19)導入血管内皮前駆細胞を用いた局所免疫賦活療法2008

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾、小西郁生
    • Organizer
      第44回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌におけるNK細胞活性化受容体のリガンド発現とその意義2008

    • Author(s)
      濱西潤三、李奎、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Activated local immunity by CCL19-transduced endothelial progenitor cells suppresses lung metastasis2008

    • Author(s)
      Hamanishi J, Mandai , Higuchi T, Yamaguchi K, Takakura K, Fujii S, M Konishi I
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌の新生血管での局所免疫賦活を目指した胚性血管内皮前駆細胞によるターゲティング療法2007

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
    • Organizer
      第12回生殖医療フォーラム
    • Place of Presentation
      奈良
    • Year and Date
      2007-06-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Programmed cell death-1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are independent parognostic factors2007

    • Author(s)
      万代昌紀
    • Organizer
      COE international symposium 2007
    • Place of Presentation
      京都
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 卵巣癌の新生血管での局所免疫賦活を目指した胚性血管内皮前駆細胞によるターゲティング療法2007

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 免疫抑制性補助シグナル分子PD-L1発現は卵巣癌の予後と相関する2007

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Prognostic significance of programmed cell death-1 ligand and tumor- infiltrating CD8+ lymphocytes in human ovarian cancer2006

    • Author(s)
      Junzo Hamanishi, Masaki Mandai. Taku Okazaki, Tasuku Honjo, Shingo Fujii
    • Organizer
      21century COE Colloquium on Immunology 2006
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Targeting of tumor vessels and activation of local tumor immunity using embryonic endothelial progenitor cells(eEPCs)lead to tumor suppression in lung metastatic model of ovarian cancer2006

    • Author(s)
      Junzo Hamanishi, Masaki Mandai, Shingo Fujii
    • Organizer
      21century COE Colloquium on Immunology 2006
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌における免疫抑制性補助シグナル分子PD-L1発現と予後との相関2006

    • Author(s)
      濱西潤三、万代昌紀、樋口壽宏、刈谷方俊、高倉賢二、藤井信吾
    • Organizer
      第40回日本婦人科腫瘍学会学術講演会シンポジウム
    • Place of Presentation
      岐阜
    • Year and Date
      2006-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 婦人科癌再発症例に対する拡大手術の試み-難治性子宮頚癌再発症例に対する骨盤半截術の経験-2006

    • Author(s)
      濱西潤三、樋口壽宏、福原健、由良茂夫、万代昌紀、刈谷方俊、高倉賢二、藤井信吾
    • Organizer
      第58回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2006-04-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌におけるProgrammed cell death - Ligand 1(PD-L1)蛋白の発現2006

    • Author(s)
      濱西潤三、万代昌紀、岡崎拓、本庶佑、藤井信吾
    • Organizer
      21世紀COEコロキウム京都大学大学院医学研究科「病態解明における基礎・臨床連携の進捗」
    • Place of Presentation
      京都
    • Year and Date
      2006-02-21
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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