Basic and clinical research for tailored chemotherapy aiming tumor dormancy of advanced and recurred ovarian cancers
| Project/Area Number |
19591936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
KOBAYASHI Hiroaki Kyushu University, 大学病院, 講師 (70260700)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKI Eisukie 九州大学, 大学病院, 助教 (90423508)
YAHATA Hideaki 九州大学, 大学病院, 助教 (30404065)
OGAWA Shinji 九州大学, 大学病院, 助教 (60380391)
UEOKA Yousuke 九州大学, 大学病院, 助教 (50372743)
SONODA、KENZOU 九州大学, 大学病院, 助教 (30294929)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | がん休眠療法 / テーラード化学療法 / メトロノミック化学療法 / 進行再発卵巣癌 / がん休眠療 |
|---|
| Research Abstract |
血管内皮細胞が少量の抗癌剤でも再現性良く障害されることに着目し、抗癌剤を少量頻回持続投与することで軽い副作用のままにがんを休眠状態に導こうというメトロノミック化学療法の有用性の検討を行った。ヒト卵巣がん由来の薬剤耐性腫瘍を用いた動物実験で、軽度の副作用にも関わらずがん休眠状態に導きやすいことが確認できた。臨床試験でも少数例ながら癌の進行を食い止めたと考えられる症例が得られ、治療中のQOLは良好であった。以上、基礎的にも臨床的にも今回のがん休眠化学療法の有効性が示唆された。
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Feasibility study of neoadjuvant chemotherapy followed by interval debulking surgery for stageIII/IV ovarian, tubal, and peritoneal cancers : Japan Clinical Oncology GroupStudy JCOG02062009
Author(s)
Onda, T., Kobayashi, H., Nakanishi, T.,Masayuki, H., Iwasaka, T., Konishi, I.,Shibata, T., Fukuda, H., Kamura, T.,Yoshikawa, H.
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Journal Title
Gynecologic oncology 113(1)
Pages: 57-62
Related Report
Peer Reviewed
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[Journal Article] Malignant transformation of maturecystic teratoma to squamous cell carcinomainvolves altered expression of p53-andp16/Rb-dependent cell cycle regulatorproteins2008
Author(s)
Iwasa, A., Oda, Y., Kurihara, S., Ohishi,Y., Yasunaga, M. , Nishimura, I., Takagi,E., Kobayashi, H., Wake, N., Tsuneyoshi,M.
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Journal Title
Pathology international 58(12)
Pages: 757-764
Related Report
Peer Reviewed
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[Journal Article] Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung2008
Author(s)
Yasunaga, M., Ohishi , Y., Nishimura, I.,Tamiya, S., Iwasa, A. , Takagi , E., Inoue,T., Yahata, H., Kobayashi, H., Wake, N. ,Tsuneyoshi, M.
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Journal Title
Pathology international 58(4)
Pages: 244-248
NAID
Related Report
Peer Reviewed
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[Journal Article] CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls2007
Author(s)
Ohishi, Y., Kaku, T., Oya, M., Kobayashi,H., Wake, N., Tsuneyoshi, M.
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Journal Title
Gynecologic Oncology 107(1)
Pages: 30-38
Related Report
Peer Reviewed
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