Investigation for ovarian cancer therapy focusing on production of human chorionic gonadotropin beta subunit
| Project/Area Number |
19591938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TASHIRO Hironori Kumamoto University, 医学部附属病院, 講師 (70304996)
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| Co-Investigator(Kenkyū-buntansha) |
KATABUCHI Hidetaka 熊本大学, 大学院・生命科学研究部, 教授 (90224451)
OHTAKE Hideyuki 熊本大学, 医学部附属病院, 助教 (60336237)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 婦人科腫瘍学 / 細胞・組織 / 遺伝子 / 癌 / 上皮性卵巣癌 / 絨毛ゴナドトロピン / βサブユニット / LH / hCG受容体 / 卵巣表層上皮 / βサブニット / 卵巣表層上皮細胞 |
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| Research Abstract |
Most patients with ovarian cancer are diagnosed at an advanced stage. Although treatment for ovarian cancer consists of surgical treatment and combination chemotherapy, there is still poor prognosis associated with drug resistance. As an experimental model system for epithelial ovarian carcinogenesis, we established immortalized human ovarian surface epithelial (OSE) cell lines. Using this system, we clarified the production of hCG α subunit and β subunit in the OSE cells, and the effect of hCG β subunit in anchorage-independent growth of the OSE cells. Moreover, many ovarian cancer tissues also expressed hCG β subunit. This discovery will provide a development of new therapeutic strategies for ovarian cancer.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.2008
Author(s)
Sangha N, Wu R, Kuick R, Powers S, Mu D, Fiander D, Yuen K, Katabuchi H, Tashiro H, Fearon ER, Cho KR.
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Journal Title
Neoplasia 10
Pages: 1362-1372
Related Report
Peer Reviewed
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