Relation between alteration of DNA mismatch repair/tumor immunologyand sensitivities of anti-cancer drugs and hormone in endometrialcancer
| Project/Area Number |
19591943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
SUSUMU Nobuyuki Keio University, 医学部, 講師 (90206459)
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| Co-Investigator(Kenkyū-buntansha) |
BANNO Banno 慶應義塾大学, 医学部, 講師 (70265875)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRASAWA Akira 慶應義塾大学, 医学部, 助教 (90296658)
SUGANO Kokichi 栃木県立がんセンター研究所, 室長 (00171124)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 婦人科腫瘍学 / 子宮体癌 / マイクロサテライト不安定性 / 腫瘍免疫 / 抗癌剤感受性 / 黄体ホルモン |
|---|
| Research Abstract |
初期子宮体癌113例に対して妊孕性温存療法の高用量黄体ホルモン(MPA)療法を行った。病変消失率はG1腺癌で86.9%、異型増殖症で95.7%と好成績を示したが、再発率はともに約50%と高値であった。再発に影響する因子を多変量解析にて検討すると、遺伝性非ポリポーシス大腸癌関連腫瘍の家系内集積性とhMLH1蛋白発現減弱の2項目が高用量MPA療法後の再発に対する独立予後因子であることが初めて示された。
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Report
(3 results)
Research Products
(72 results)
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[Journal Article] Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes2007
Author(s)
Banno K, Yanokura M, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Tsukazaki K, Aoki D
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Journal Title
Int J Oncol 31(4)
Pages: 713-720
Related Report
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[Presentation] Outcome of fertility-preserving MPA therapy for young patients with atypical endometrial hyperplasia complex or different grades of endometrial cancer2008
Author(s)
Susumu N, Hirasawa A, Ichikawa Y, Suemori T, Kobayashi Y, Nomura H, Kataoka F, Tominaga E, Suzuki A, Tsuda H, Banno K, Aoki D
Organizer
The XIth International Gynecologic Cancer Society
Place of Presentation
Bangkok, Thailand
Year and Date
2008-10-27
Related Report
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[Presentation] Cyclooxygenase-2 expression andintra-tumor cell infiltrating CD8-positive lymphocytes (ITCIL) are associated with recurrence and prognosis in advanced endometrial cancer2007
Author(s)
Suemori T, Susumu N, Tsuruta T, Ichikawa Y , Nomura H, Kataoka F, Hirasawa A, Tominaga E, Banno K, Suzuki A, Daisuke A
Organizer
International Meeting of the European Society of Gynaecological Oncology
Place of Presentation
Berlin, Germany
Year and Date
2007-10-30
Related Report
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[Presentation] Analysis of Prognotic risk factors among patients with early endmetrial cancer after fertility-preserving high-dose MPA (Medroxy-Progesteron acetate) therapy2007
Author(s)
Ichikawa Y, Susumu N, Tsuruta T, Nomura H, Kataoka F, Hirasawa A, Tominaga E, Banno K, Suzuki A, Daisuke A
Organizer
International Meeting of the European Society of Gynaecological Oncology
Place of Presentation
Berlin, Germany
Year and Date
2007-10-30
Related Report
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