Effects of functional electrical stimulation on reinnervation of intrinsic laryngeal muscles

• Project/Area Number: 19591951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KATADA Akihiro Asahikawa Medical College, 医学部, 講師 (90281899)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 再生医学 / 神経科学 / 機能的電気刺激 / 喉頭科学

Research Abstract

本研究では、機能的電気刺激の内喉頭筋再支配に対する影響について基礎的な実験成績を収集した。ラット下腿をモデルとした実験では、機能的電気刺激によって1) 脱神経後に生じる廃用性筋萎縮が抑制されること、2) 脱神経後の神経再支配が促進されること、3) 神経再支配が起こったときの神経終末とアセチルコリンレセプターとの機能的接続が増加することが示された。イヌの喉頭を用いた実験では、完全埋め込み型の電気刺激装置と刺激電極によって喉頭運動を回復させることに成功した。

Research Products

• [Journal Article] Evaluation of a deep brain stimulation electrode for laryngeal pacing (2008)
  • Author(s): Katada A, Himbergen DV, Kunibe I, Nonaka S, Harabuchi Y, Huang S, Billante C, Zealear DL
  • Journal Title: Annals of Otology, Rhinology & Laryngology 117(8) Pages: 621-629
  • Peer Reviewed
• [Journal Article] Laryngeal pacing with an advanced generation implantable stimulator (2008)
  • Author(s): Katada A, Ota R, Arakawa T, Nomura K, Kunibe I, Billante C, Zealear DL, Harabuchi Y
  • Journal Title: 15th World Congress for Bronchology (WBC) and 15th World Congress for Bronchoesophagology (WCBE) Proceedings Pages: 113-137
• [Journal Article] Evaluation of a deep brain stimulation electrode for Laryngeal pacing (2008)
  • Author(s): Katada A, et.al.
  • Journal Title: Annals of Otology, Rhinology & Laryngology 117 Pages: 621-629
  • Peer Reviewed
• [Journal Article] Laryngeal oacing with an advanced generation implantable stimulator (2008)
  • Author(s): Katada A, et.al.
  • Journal Title: 15th World Congress for Bronchology (WBC) and 15th World Congress for Bronchoesophagology (WCBE) 1 Pages: 133-137
• [Journal Article] Evaluation of a deep brain stimulation electrode for Laryngeal pacing (2008)
  • Author(s): Katada A, et. al.
  • Journal Title: Annals of Otology, Rhinology & Laryngology (In Press)
  • Peer Reviewed
• [Journal Article] Fos expression in the brainstem nuclei evoked by nasal air-jet stimulation in rats (2007)
  • Author(s): Kunibe I, et. al.
  • Journal Title: American Journal of Rhinology 21 Pages: 128-132
  • Peer Reviewed
• [Journal Article] Inducible nitric oxide synthase expression in various laryngeal lesions in relation to carcinogenesis, angiogenesis, and patients' prognosis (2007)
  • Author(s): Shigyo H, et. al.
  • Journal Title: Acta Oto-laryngologica 127 Pages: 970-979
  • Peer Reviewed
• [Presentation] 両側反回神経麻痺に対する埋め込み型電気刺激装置による喉頭ペーシング治療の有用性 (2009)
  • Author(s): 國部勇、他
  • Organizer: 第21回日本喉頭科学会
  • Place of Presentation: 前橋市
• [Presentation] Effects of electrical stimulation on neuromuscular junctions in denervated muscles (2008)
  • Author(s): Nomura K. Katada A, Ota R, Kunibe I, Harabuchi Y
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience, Washington DC
  • Place of Presentation: USA
• [Presentation] Rehabilitation of the bilaterally paralyzed canine larynx with an implantable stimulation device (2008)
  • Author(s): Kunibe I, Bekeny J, Singh V, Himbergen DV, Katada A, Nomura K, Huang S, Harabuchi Y, Billante C, Zealear DL
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience, Washington DC
  • Place of Presentation: USA
• [Presentation] The effects of chronic electrical stimulation on denervated laryngeal muscles (2008)
  • Author(s): Katada A, Kunibe I, Arakawa T, Ota R, Nomura K, Zealear DL, Harabuchi Y
  • Organizer: Society for Neuroscience 38th Annual Meeting, Washington DC
  • Place of Presentation: USA
• [Presentation] 長期間の機能的電気刺激による内喉頭筋筋線維の変化 (2008)
  • Author(s): 片田彰博, 國部勇, 野村研一郎, 高原幹, 片山昭公, 坂東伸幸, 林達哉, 原渕保明
  • Organizer: 第60回日本気管食道科学会
  • Place of Presentation: 熊本市
• [Presentation] Glycogen Depletion for Study of Neuromuscular Connectivity (2008)
  • Author(s): Kunibe I, Singh V, Bekeny J, Nomura K, Harabuchi Y, Billante C, Katada A, Zealear DL
  • Organizer: The 112th Annual meeting of AAO-HNS, Chicago
  • Place of Presentation: USA
• [Presentation] Effects of electrical stimulation on neuromuscular junctions in denervated muscles (2008)
  • Author(s): Nomura K. Katada A, Ota R, Kunibe I, Harabuchi Y
  • Organizer: 15th World Congress for Bronchology (WBC) and 15th World Congress for Bronchoesophagology (WCBE)
  • Place of Presentation: Tokyo
• [Presentation] Laryngeal pacing with an advanced generation implantable stimulator (2008)
  • Author(s): Katada A, Ota R, Nomura K, Kunibe I, Billante C, Zealear DL, Harabuchi Y
  • Organizer: 15th World Congress for Bronchology (WBC) and 15th World Congress for Bronchoesophagology (WCBE)
  • Place of Presentation: Tokyo
• [Presentation] Glvcoaen Deoletion for Study of Neuromuscular Connectivity (2008)
  • Author(s): Kunibe I, et.al.
  • Organizer: Annual meeting of AAO-HNS
  • Place of Presentation: Chicago USA
• [Presentation] The effects of chronic electrical stimulation on denervated laryngeal muscles (2008)
  • Author(s): Katada A, et.al.
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] Rehabilitation of the bilaterally paralyzed canine larynx with an implantable stimulation device (2008)
  • Author(s): Kunibe I, et.al.
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington DC. USA
• [Presentation] Effects of electircal stimulation on neuromuscular junctions in denervated muscles (2008)
  • Author(s): Nomura K, et.al.
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington DC. USA
• [Presentation] 長期的な機能的電気刺激が筋へ及ぼす影響 (2007)
  • Author(s): 國部勇, 片田彰博, 野村研一郎, 坂東伸幸, 林達哉, 原渕保明
  • Organizer: 第26回頭頸部自律神経研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-08-23
• [Presentation] Progressive barbiturate anesthesia and isometric loading insures glycogen depletion of any muscle fiber type when studying neuromuscular connectivity (2007)
  • Author(s): Kunibe I, Singh V, Bekeny JR, Huang S, Billante CR, Katada A, Zealear DL
  • Organizer: The 37th Society for Neuroscience Annual Meeting.
  • Place of Presentation: San Diego. USA
• [Presentation] Laryngeal pacing with a new implantable stimulator (2007)
  • Author(s): Katada A, Himbergen D, Billante C, Kunibe I, Harabuchi Y, Zealear DL
  • Organizer: acute canine study The 37th Society for Neuroscience Annual Meeting
  • Place of Presentation: San Diego. USA
• [Presentation] 機能的電気刺激による神経筋接合部の変化についての検討 (2007)
  • Author(s): 野村研一郎, 片田彰博, 太田亮, 國部勇, 原渕保明
  • Organizer: 第59回日本気管食道科学会
  • Place of Presentation: 前橋市
• [Presentation] 埋め込み型電気刺激装置を用いた喉頭ペーシング (2007)
  • Author(s): 片田彰博, 太田亮, 國部勇, 原渕保明
  • Organizer: 第108回日本耳鼻咽喉科学会総会
  • Place of Presentation: 金沢市
• [Presentation] Laryngeal pacing with a new implantable stimulator: acute canine study (2007)
  • Author(s): Katada A, et. al.
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA