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Actin related proteins in the mechanoelectrical transduction of the hair cells and hereditary hearing loss DFNA20/26

Research Project

Project/Area Number 19591953
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionTohoku University

Principal Investigator

KATORI Yukio  Tohoku University, 大学院・医学系研究科, 非常勤講師 (20261620)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Daisuke  東北大学, 大学院・医学系研究科, 非常勤講師 (70361102)
渡邊 健一  東北大学, 病院, 助教 (10431579)
宮崎 浩充  東北大学, 大学院・医学系研究科, 非常勤講師 (70431575)
Research Collaborator DAVID N Furness  Keele University, United Kingdom, Director of electron microscopic unit
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords神経科学 / 細胞組織 / 蛋白質 / 細胞・組織
Research Abstract

モルモット蝸牛試料を界面活性剤で脱膜処理後に細胞質可溶性成分を除外して電界放射型走査電子顕微鏡により観察し、従来に無い広い範囲での不動毛細胞骨格の超微細構造の観察を可能にした。音受容に関係する有毛細胞不動毛のアクチンおよび関連蛋白分子の三次元的配列を明らかにした。加えて細胞外カルシウム濃度によるそれらの構造の変化を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] 2008) The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium2008

    • Author(s)
      Furness DN, Katori Y, Kumar N, and Hackney CM
    • Journal Title

      Neuroscience 154

      Pages: 10-21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium2008

    • Author(s)
      Furness DN, Katori Y, Kumar N and Hackney CM
    • Journal Title

      Neuroscience 154(1)

      Pages: 10-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of Exposure to Different Concentrations of Extracellular Calcium on Tip-Link Dimensions2008

    • Author(s)
      David Furness, Nirmal Kumar, Yukio Katori, Carole Hackney
    • Organizer
      34th annual Midwinter meetion of the Association Research in Otolaryngology
    • Place of Presentation
      Phoenix, Arizona, USA
    • Year and Date
      2008-02-17
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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