Roles of prostaglandin metabolism in the pathogenesis of upper airway allergic inflammation and development of novel therapeutic approaches

• Project/Area Number: 19591971
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: OKANO Mitsuhiro Okayama University, 大学院・医歯薬学総合研究科, 准教授 (60304359)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アレルギー性鼻炎 / 好酸球性副鼻腔炎 / プロスタグランジン / サイトカイン / 鼻茸 / DP / CRTH2 / EP / PGD2 / PGE2 / 慢性副鼻腔炎 / エンテロトキシン / ケモカイン / トロンボキサン / スギ花粉症

Research Abstract

アレルギー性鼻炎や好酸球性副鼻腔炎はアレルギーが関与する代表的な上気道の炎症性疾患である。今回我々は、これらの疾患の病態にプロスタグランジン(PG)代謝が関与するのか検討した。その結果、アレルギー性鼻炎や好酸球性副鼻腔炎の病態には、PGD2やPG2がそれぞれ促進的および抑制的に働くことを明らかにした。従ってこれら上気道アレルギー疾患の新規治療法として、PGD2とその受容体を阻害する系、あるいはPGE2とその受容体を活性化する系の開発が有望であることが示唆された。

Research Products

• [Journal Article] suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly via an EP2-mediated pathway in nasal polyps (2009)
  • Author(s): Okano, M, Fujiwara, T, et.al.
  • Journal Title: Journal of Allergy and Clinical Immunology 123 Pages: 868-874
  • Peer Reviewed
• [Journal Article] Aging exacerbates restraint stress-induced inhibition of antigen-specific antibody production in mice (2009)
  • Author(s): Ichihara, Y, Okano, M, et.al.
  • Journal Title: Allergology International 58 Pages: 119-124
  • NAID: 10025109304
  • Peer Reviewed
• [Journal Article] 好酸球性炎症におけるエンテロトキシンの作用とPGE2による制御 (2009)
  • Author(s): 岡野光博
  • Journal Title: 日鼻誌 48 Pages: 15-17
  • NAID: 130004545951
• [Journal Article] 鼻茸形成の機序とアレルギー、プロスタグランジン代謝 (2009)
  • Author(s): 岡野光博
  • Journal Title: 臨床免疫・アレルギー科 51 Pages: 179-186
  • NAID: 40016500616
• [Journal Article] アレルギー性鼻炎の薬物治療プロスタグランジンD2・トロンボキサンA2受容体拮抗薬 (2009)
  • Author(s): 岡野光博
  • Journal Title: 医薬ジャーナル 44 Pages: 903-999
• [Journal Article] アレルギー性上気道炎 (2009)
  • Author(s): 岡野光博
  • Journal Title: アレルギーの臨床 29 Pages: 24-30
• [Journal Article] PGE2 suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly via an EP2-mediated pathway in nasal polyps. (2009)
  • Author(s): Okano M, et al.
  • Journal Title: Journal of Allergy and Clinical Immunology 123 Pages: 868-874
  • Peer Reviewed
• [Journal Article] 好酸球性炎症におけるエンテロトキシンの作用とPGE2による制御 (2009)
  • Author(s): 岡野光博
  • Journal Title: 目鼻誌 48 Pages: 15-17
  • NAID: 130004545951
• [Journal Article] A randomized-double-blind comparative study of sublingual immunotherapy for cedar pollinosis (2008)
  • Author(s): Okubo, K, Goto, M, Okano, M, et.al.
  • Journal Title: Allergology International 57 Pages: 265-275
  • NAID: 10024419926
  • Peer Reviewed
• [Journal Article] Expression and characterization of PGD2 receptors in chronic rhinosinusitis : Modulation of DP and CRTH2 by PGD2 (2008)
  • Author(s): Yamamoto, M, Okano, M, et.al.
  • Journal Title: International Archives of Allergy and Immunology 148 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Expression of inflammatory mediators in the otitis media induced by Helicobacter pylori antigen in mice (2008)
  • Author(s): Kariya, S, Okano, M, et.al.
  • Journal Title: Clinical and Experimental Immunology 154 Pages: 134-140
  • Peer Reviewed
• [Journal Article] Current status of intranasal glucocoricoids in the management of allergic rhinitis (2008)
  • Author(s): Okano, M.
  • Journal Title: Clinical and Experimental Allergy Reviews 8 Pages: 57-62
  • Peer Reviewed
• [Journal Article] CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice (2008)
  • Author(s): Nomiya, R, Okano, M, et.al.
  • Journal Title: Journal of Immunology 180 Pages: 5680-5688
  • NAID: 130004505661
  • Peer Reviewed
• [Journal Article] アレルギー性鼻炎の新しい治療薬開発の現状-免疫療法薬を中心に- (2008)
  • Author(s): 岡野光博
  • Journal Title: アレルギー・免疫 15 Pages: 358-365
• [Journal Article] CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. (2008)
  • Author(s): Nomiya R, Okano M, et al.
  • Journal Title: Journal of Immunology 180 Pages: 5680-5688
  • NAID: 130004505661
  • Peer Reviewed
• [Journal Article] Current status of intranasal glucocoricoids in the management of allergic rhinitis. (2008)
  • Author(s): Okano M
  • Journal Title: Clinical and Experimental Allergy Reviews 8 Pages: 57-62
  • Peer Reviewed
• [Journal Article] Expression and characterization of PGD2 receptors in chronic rhinosinusitis : Modulation of DP and CRTH2 by PGD2. (2008)
  • Author(s): Yamamoto M, Okano M, et al.
  • Journal Title: International Archives of Allergy and Immunology 148 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Expression of inflammatory mediators in the otitis media induced by Helicobacter pylori antigen in mice. (2008)
  • Author(s): Kariya s, Okano M
  • Journal Title: Clinical and Experimental Immunology 154 Pages: 134-140
  • Peer Reviewed
• [Journal Article] CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. (2008)
  • Author(s): Nomiya R, Okano M, et. al.
  • Journal Title: Journal of Immunology 180 Pages: 5680-5688
  • NAID: 130004505661
  • Peer Reviewed
• [Journal Article] STAT1 is involved in pathogenesis of murine allergic rhinitis (2007)
  • Author(s): Hattori, H, Okano, M, et.al.
  • Journal Title: American Journal of Rhinology 21 Pages: 241-247
  • Peer Reviewed
• [Journal Article] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T cel responses (2007)
  • Author(s): Sugata, Y, Okano, M, et.al.
  • Journal Title: Immunology 121 Pages: 266-275
  • Peer Reviewed
• [Journal Article] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T cel responses. (2007)
  • Author(s): Sugata Y, Okano M, et. al.
  • Journal Title: Immunology 121 Pages: 266-275
  • Peer Reviewed
• [Journal Article] STAT1 is involved in pathogenesis of murine allergic rhinitis. (2007)
  • Author(s): Hattori H, Okano M, et. al.
  • Journal Title: American Journal of Rhinology 21 Pages: 241-247
  • Peer Reviewed
• [Presentation] PGE2による慢性副鼻腔炎における好酸球性炎症の制御 (2009)
  • Author(s): 牧原靖一郎、岡野光博ら
  • Organizer: 第27回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-02-14
• [Presentation] The Role of Prostaglandins in the Pathogenesis of Chronic Rhinosinusitis (2008)
  • Author(s): Okano M.
  • Organizer: KyungHee International Rhinologic Symposium
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2008-11-08
• [Presentation] 好酸球性炎症におけるエンテロトキシンの作用とPGE2による制御 (2008)
  • Author(s): 岡野光博
  • Organizer: 第47 回日本鼻科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-25
• [Presentation] 好酸球性炎症におけるエンテロトキシンの作用とPGE2による制御 (2008)
  • Author(s): 岡野光博
  • Organizer: 第47回日本鼻科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-25
• [Presentation] エンテロトキシンによる鼻茸細胞からのサイトカイン産生とCOX代謝の関与 (2008)
  • Author(s): 岡野光博ら
  • Organizer: 第109回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-17
• [Presentation] エンテロトキシンによる鼻茸細胞からのサイトカイン産生とcox代謝の関与 (2008)
  • Author(s): 岡野光博ら
  • Organizer: 第109回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-17
• [Presentation] 鼻茸形成におけるプロスタグランジン合成酵素の関与 (2007)
  • Author(s): 岡野光博
  • Organizer: 第57回日本アレルギー学会秋季学術大会(シンポジウム9)
  • Place of Presentation: 横浜
  • Year and Date: 2007-11-02
• [Presentation] 花粉症治療の未来 (2007)
  • Author(s): 岡野光博
  • Organizer: 第57回日本アレルギー学会秋季学術大会(イブニングシンポジウム11)
  • Place of Presentation: 横浜
  • Year and Date: 2007-11-02
• [Presentation] マウススギ花粉症モデルにおけるCRTH2の役割 (2007)
  • Author(s): 岡野光博
  • Organizer: 第46回日本鼻科学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2007-09-29
• [Presentation] マウススギ花粉症モデルにおけるCRTH2の役割 (2007)
  • Author(s): 岡野光博
  • Organizer: 第46回日本鼻科学会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2007-09-29
• [Book] ガイドライン外来診療2009 (2009)
  • Author(s): 岡野光博
  • Total Pages: 621
  • Publisher: 日経メディカル開発