• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic and clinical research for the protection and treatment of age-related inner ear disorders by controlling age-related factors

Research Project

Project/Area Number 19591972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHiroshima University

Principal Investigator

TAKUMIDA Masaya  Hiroshima University, 病院, 講師 (00179590)

Research Collaborator HIRAKAWA Katsuhiro  広島大学, 大学院・医歯薬学総合研究科, 教授 (30144843)
ISHIBASHI Takuya  広島大学, 病院, 病院 (50448239)
HAMAMOTO Takao  広島大学, 病院, 医員 (70448249)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords内耳 / 加齢 / 老人性難聴 / 抗酸化剤 / TRP チャネル / klotho / めまい / マウス / TRPチャネル / Klotho / TRPV / メニエール病
Research Abstract

加齢性内耳障害の予防・治療を目的に、基礎的研究では内耳にklotho、SOD、TRPチャネル28個が存在し、感覚細胞の興奮伝達、内リンパの恒常性の調節や内耳障害の軽減に働くこと、加齢によりSOD、klotho、TRPV5、6の発現が低下し内耳障害が起こることを明らかにした。また、内リンパ水腫に加えてめまいを生じる動物モデルを開発し、めまい発作の発症機序を解明した。臨床的研究では老人性難聴での抗酸化剤治療の有効性を示した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (8 results)

  • [Journal Article] Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear2009

    • Author(s)
      Takumida M, Ishibashi T, Hamamoto T, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear2009

    • Author(s)
      Takumida M, Ishibashi T, Hamamoto T, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radical scavengers for elderly patients with age-related hearing loss2009

    • Author(s)
      Takumida M, Anniko M
    • Journal Title

      Acta Otolaryngol 129

      Pages: 36-44

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in transientreceptor potential vanilloid (TRPV) 1, 2, and 4 expression in mouse inner earfollowing gentamicin challenge2009

    • Author(s)
      Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 129

      Pages: 116-126

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge2009

    • Author(s)
      Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 129

      Pages: 116-126

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear2009

    • Author(s)
      Takumida M, Ishibashi T, Hamamoto T, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 129(In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear2009

    • Author(s)
      Takumida M, Ishibashi T, Hamamoto T, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 129(In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new a5. imal model foe Meniere's disease2008

    • Author(s)
      Takumida M, Akagi N, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 263-271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential vanilloid (TRPV) 1,2,3 and 4 in mouse inner ear2008

    • Author(s)
      Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 1286-1293

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of inner ear blood flow changes on the endolymphatic sac2008

    • Author(s)
      Akagi N, Takumida M, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 1187-1195

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 女性めまい患者の年齢期別臨床検討-若年期・更年期・老年期の比較-2008

    • Author(s)
      大谷真喜子、工田昌矢
    • Journal Title

      Equilibrium Res 67

      Pages: 130-140

    • NAID

      10026087292

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential vanilloid (TRPV)1, 2, 3 and 4 in mouse inner ear2008

    • Author(s)
      Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 1286-1293

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 女性めまい患者の年齢期別臨床検討-若年期・更年期・老年期の比較-2008

    • Author(s)
      大谷真喜子, 工田昌矢
    • Journal Title

      Equilibrium Res 67

      Pages: 130-140

    • NAID

      10026087292

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new animal model for Meniere's disease2008

    • Author(s)
      Takumida M, Akagi N, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 263-271

    • NAID

      120001192642

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of acute endolymphatic hydrops overload on the endolymphatic sac2008

    • Author(s)
      Akagi N, Takumida M, Anniko M
    • Journal Title

      Acta Otolaryngol 128

      Pages: 239-244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of transient receptor potential vanilloid (TRPV) 1.2.3. and 4 in mouse inner ear2008

    • Author(s)
      Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol 128(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of aquaporin-2, vasopressin type 2 receptor, transient receptor channel vanilloid (TRPV) 1 and TRPV4 in the human endolymphatic sac2007

    • Author(s)
      Taguchi D, Takeda T, Kakigi A, Takumida M, Nishioka R, Kitano H
    • Journal Title

      Laryngoscope 117

      Pages: 24-29

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of edaravone against endolymphatic hydrops2007

    • Author(s)
      Takumida M, Takeda T, Takeda S, Kakigi A, Nakatani H, Anniko M
    • Journal Title

      Acta Otolaryngol 127

      Pages: 1124-1131

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of aquaporin-2, vasopressin type 2 receptor, transient receptor potential channel vanilloid (TRPV) 1, and TRPV4 in the human endolymphatic sac2007

    • Author(s)
      Taguchi D, Takeda T, Kakigi A, Takumida M, Nishioka R, Kitano H
    • Journal Title

      Laryngoscope 117

      Pages: 24-29

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] モデル動物からみたメニエール病の病態2008

    • Author(s)
      工田昌矢、平川勝洋
    • Organizer
      第67回日本めまい平衡医学会
    • Place of Presentation
      秋田
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] マウス内耳でのTRPM、TRPA1の発現2008

    • Author(s)
      工田昌矢、石橋卓弥、平川勝洋
    • Organizer
      第17回日本耳科学
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-17
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス内耳でのTRPM、TRPA1の発現2008

    • Author(s)
      工田昌矢, 石橋卓弥, 平川勝洋
    • Organizer
      第17回日本耳科学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高齢者の感音難聴に対する抗酸化剤の治療効果2008

    • Author(s)
      工田昌矢、大谷真喜子、東稔由加里
    • Organizer
      第8回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] GM投与によるマウス内耳TRPVの発現の変化2008

    • Author(s)
      石橋卓弥、工田昌矢、濱本隆夫、立川隆治、平川勝洋
    • Organizer
      第109回日本耳鼻咽喉科学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Endolymphatic hydrops caused by treatment of aldosterone and/or lipopolysaccharide : A new animal model for Meniere's disease2008

    • Author(s)
      Takumida M, Hirakawa K, Akagi N, Anniko M
    • Organizer
      XXV Barany Society Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] メニエール病の新しい動物モデル2007

    • Author(s)
      工田昌矢、平川勝洋
    • Organizer
      第66回日本めまい平衡医学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-15
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] マウス内耳でのTRPVの発現2007

    • Author(s)
      工田昌矢、石橋卓弥、平川勝洋
    • Organizer
      第17回日本耳科学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-18
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi