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Differentiation of multipotent stem cells into inner hair cells for regeneration of inner ear

Research Project

Project/Area Number 19591985
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagoya City University

Principal Investigator

OZEKI Masashi  Nagoya City University, 大学院医学研究科, 研究員 (80315887)

Co-Investigator(Kenkyū-buntansha) HAMAJIMA Yuki  名古屋市立大学, 大学院医学研究科, 助教 (30343403)
NAKAMURA Yoshihisa  名古屋市立大学, 大学院医学研究科, 助教 (90360023)
TAKAHASHI Mariko  名古屋市立大学, 大学院医学研究科, 助教 (00336687)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords多能幹細胞 / 内耳再生 / 内耳性難聴 / 難聴 / 組織幹細胞 / 感覚器再生 / 内耳多能幹細胞 / 鼻腔粘膜多能幹細胞 / Nestin / mathl / レチノン酸 / ビタミンB12 / ヘパリン
Research Abstract

胎生18 日齢のマウスから蝸牛を取り出し、組織由来多能幹細胞を培養、分離し、セルラインとして確立した。また、音響傷害性難聴モデルマウスの作成に成功した。
しかし、多能幹細胞へのマイコプラズマの感染により、実験は終了となった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Directed differentiation of mouse cochlear neural progenitors in vitro.2008

    • Author(s)
      Lin J
    • Journal Title

      Am J Physiol Cell Physiol. 296(3)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Idl Induces the Proliferation of Cochlear Sensory epithelial cells via the NF-κB/Cyclin D1 Pathway in vitro2007

    • Author(s)
      小関 晶嗣
    • Journal Title

      J neurosci Res 85(3)

      Pages: 515-524

    • Related Report
      2008 Final Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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