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Model experiments on BPPV mechanism and estrogen receptor distribution within the vestibular organ.

Research Project

Project/Area Number 19591989
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionTokyo Medical University

Principal Investigator

SUZUKI Mamoru  Tokyo Medical University, 医学部, 教授 (80116607)

Co-Investigator(Kenkyū-buntansha) 清水 顕  東京医科大学, 医学部, 助教 (70366128)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords良性発作性頭位めまい症 / 耳石 / 前庭 / 更年期 / 卵形嚢 / 半規管 / エストロゲン / 半規管クプラ / 前庭器 / 動物モデル / 耳石器 / エストロゲン受容体 / 摘出前庭器 / マウス / 高齢者 / 発作性頭位めまい症 / クプラ / 更年期モデル / エストロゲンレセプター
Research Abstract

Estrogen receptors (ER) in the vestibular organ were investigated by immunochemical method. ER was distributed more in the female and it markedly decreased in the elderly animals. Dislodge of the otoconia due to mechanical stimulus was more pronounced in the elderly and menopausal animals, suggesting otoconial metabolic disorder contributes to emergence of benign paroxysmal positional vertigo. Stability of the otoconia placed on the utricular macula was studied using the frog model. The otoconial stability depends on condition of the utricular macula, but it became stabilized in 5 min., suggesting that the physical therapy is still useful even if the utricular macula is disturbed.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Book (1 results)

  • [Journal Article] Effects of age and sex on the expression of estrogen receptor alpha and beta in the mouse inner ear2009

    • Author(s)
      Motohashi R, Takumida M, Shimizu A, Konomi U, Fujita K, Hirakawa K, Suzuki M, Anniko M
    • Journal Title

      Acta Otolaryngologica 130

      Pages: 204-214

    • Related Report
      2009 Final Research Report
  • [Journal Article] Morphologi-cal change of the cupula due to an ototoxic agent; a comparison with semicircular canal pathology2009

    • Author(s)
      Konomi U, Suzuki M, Otsuka K, Shimizu A, Inagaki T, Hasegawa G, ShimizuS, Motohashi R
    • Journal Title

      Acta Otolaryngologica

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of age and sex on the expression of estrogen receptoralpha and beta in the mouse inner ear2009

    • Author(s)
      Motohashi R, Takumida M, Shimizu A, Konomi U, Fujita K, Hirakawa K, Suzuki M, Anniko M
    • Journal Title

      Acta Otolaryngologica 130

      Pages: 204-214

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological change of the cupula due to an ototoxic agent; a comparison with semicircular canal pathology2009

    • Author(s)
      Konomi U, Suzuki M, Otsuka K, Shimizu A, Inagaki T, Hasegawa G, Shimizu S, Motohashi R
    • Journal Title

      Acta Otolaryngologica

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内耳疾患の経過中に発症したBPPV様症候の検討2008

    • Author(s)
      稲垣太郎, 湯川久美子, 市村彰英, 萩原晃, 小川恭生, 北島尚治, 中村珠理, 鈴木衞
    • Journal Title

      Equilibrium Research 67

      Pages: 18-23

    • NAID

      10026087029

    • Related Report
      2009 Final Research Report
  • [Journal Article] 内耳疾患の経過中に発症したBPPV様症候の検討2008

    • Author(s)
      稲垣太郎, 他8名
    • Journal Title

      Equilibrium Research 67

      Pages: 18-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者の良性発作性頭位めまい症2008

    • Author(s)
      小川恭生, 他2名
    • Journal Title

      ENTONI 87

      Pages: 68-73

    • Related Report
      2008 Annual Research Report
  • [Presentation] クプラの変性が半規管反応性に及ぼす効果について2009

    • Author(s)
      大塚康司, 鈴木衛, 飯村陽一, 稲垣太郎, 清水重敬, 許斐氏元
    • Organizer
      第68回日本めまい平衡医学会
    • Place of Presentation
      徳島市
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス内耳におけるエストロゲンレセプターα、βの発現への加齢、性別の影響2009

    • Author(s)
      本橋玲, 工田昌也, 鈴木衞
    • Organizer
      第19回日本耳科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Model experiments of otoconia stabi-lity after canalith repositioning procedure of BPPV2009

    • Author(s)
      Otsuka K, Suzuki M, Shimizu S, Konomi U, Ogawa Y, Hayashi M
    • Organizer
      19th World Congress of Otorhinolaryngology
    • Place of Presentation
      Sao Paulo
    • Year and Date
      2009-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Model experiments of otoconia stability after canalith reposi-tioning procedure of BPPV2009

    • Author(s)
      Otsuka K, Suzuki M, Shimizu S, Konomi U, Ogawa Y, Hayashi M
    • Organizer
      19th World Congress of Otorhinolaryngol-ogy
    • Place of Presentation
      Sao Paulo
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 振動負荷による更年期や高齢モデルラットでの球形嚢耳石の形態変化2008

    • Author(s)
      許斐氏元, 清水顕, 本橋玲, 鈴木衞
    • Organizer
      第67回日本めまい平衡医学会
    • Place of Presentation
      秋田市
    • Year and Date
      2008-10-31
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 実験的にみたBPPV頭位療法後の耳石塊の動態について2008

    • Author(s)
      大塚康司, 鈴木衞, 清水重敬, 許斐氏元, 小川恭生, 林麻美
    • Organizer
      第67回日本めまい平衡医学会
    • Place of Presentation
      秋田市
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Morphological change of the semicircular canal cupula and its involvement in BPPV etiology2008

    • Author(s)
      Suzuki M
    • Organizer
      82th Collegium Otorhinolaryngologicum Amicitiae Sacrum Meeting
    • Place of Presentation
      Berlin
    • Year and Date
      2008-08-25
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 良性発作性頭位めまい症. 年齢による比較2008

    • Author(s)
      小川恭生, 他6名
    • Organizer
      第70回耳鼻咽喉科臨床学会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-06-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Positional and positioning vertigo. Morphological change of the cupula as a possible etiology of intractable BPPV.2008

    • Author(s)
      Suzuki M, Otsuka K, Inagaki T, Shimizu S, Konomi U, Hasegawa G, Kitajima N, Ogawa Y
    • Organizer
      25th Barany Society Meeting
    • Place of Presentation
      京都市
    • Year and Date
      2008-04-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Positional and positioning vertigo. Morphological change of the cupula as a possible etiology of intractable BPPV2008

    • Author(s)
      Suzuki M, et al.
    • Organizer
      25th Barany Society Meeting
    • Place of Presentation
      京都市
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Influence of aging on prognosis of BPPV2008

    • Author(s)
      Shimizu S, et al.
    • Organizer
      25th Barany Society Meeting
    • Place of Presentation
      京都市
    • Year and Date
      2008-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 振子様刺激によるクプラの偏位の観察2007

    • Author(s)
      大浮 康司, 鈴木 衞, 他
    • Organizer
      第108回日本耳鼻咽喉科学会
    • Place of Presentation
      金沢市
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Book] Experiments of semicircular ampulla and BPPV mechanism. Neues aus Forschung und Klinik. 6. Hennig-Symposium.2008

    • Author(s)
      Suzuki M
    • Publisher
      Springer-Verlag
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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