basic study of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor
| Project/Area Number |
19591997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kurume University |
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Principal Investigator |
UMENO Hirohito Kurume University, 医学部, 准教授 (40203583)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Kiminori 久留米大学, 医学部, 教授 (70196228)
SHIROUZU Hidetaka 久留米大学, 医学部, 講師 (90299454)
CHITOSE Syun-ichi 久留米大学, 医学部, 講師 (20299514)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 声帯麻痺 / 声帯内脂肪注入術 / 甲状軟骨形成術I型 / 披裂軟骨内転術 / 音声検査 / ボディマスインデックス / 肝細胞増殖因子産生非増殖方アデノウイルスベクター / 血管内皮細胞 / 肝細胞増殖因子 / アデノウイルスベクター / 成犬 / 喉頭切片標本 / 免疫化学染色 / 走査型電子顕微鏡 / 喉頭枠組み手術 / 反回神経麻痺 / 神経即時再建 / 肝細胞増殖因 / 免疫科学染色 |
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| Research Abstract |
Autologous fat injection laryngoplasty was significantly found to be a more effective and reliable therapy for improving voice function in patients with vocal fold paralysis, compared with framework surgery. Injected fat volume shown a tendency to reduce in patient with Body Mass Index was high. Autologous fat injection laryngoplasty was effective in patient whose width between vocal process was large before surgery. Injection into the vocal fold of autologous fat containing an adenoviral vector expressing hepatocyte growth factor can reduce subsequent resorption of injected fat.
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Report
(4 results)
Research Products
(16 results)
