Morphological Investigations of cells and extracellular matrices of the human vocal fold. Functions of maculae flavae and cells in the human vocal fold mucosa.

• Project/Area Number: 19591998
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kurume University
• Principal Investigator: SATO Kiminori Kurume University, 医学部, 准教授 (70196228)
• Co-Investigator(Kenkyū-buntansha): IZUMARU Shinsuke 久留米大学, 医学部, 助教 (80352178) ; NAKASHIMA Tadashi 久留米大学, 医学部, 教授 (70117183)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 声帯 / 喉頭 / 細胞 / 細胞外マトリックス / 黄斑 / ビタミンA貯蔵星型細胞 / ビタミンA貯蔵細胞

Research Abstract

ヒト声帯の黄斑の機能と黄斑内のビタミンA貯蔵星型細胞の機能を研究した。
1)ヒト声帯黄斑のビタミンA貯蔵星型細胞を細胞培養し継代培養に成功した。
2)ヒト声帯黄斑に密に分布するビタミンA貯蔵星型細胞の機能は、声帯粘膜固有層に分布する通常の線維芽細胞と機能的に違うのかを放射線感受性の観点から研究した。
3)未熟な新生児の声帯黄斑内のビタミンA貯蔵星型細胞がどのような要因により活性化され、ヒト固有の声帯粘膜の層構造を構築し、ヒト声帯粘膜の成長・発達に関与しているかを研究した

Research Products

• [Journal Article] Stellate Cells in the Human Child Vocal Fold Macula Flava. (2009)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi
  • Journal Title: Laryngoscope 119 Pages: 203-210
  • Peer Reviewed
• [Journal Article] Stellate Cells in the Human Child Vocal Fold Macula Flava (2009)
  • Author(s): Sato Kiminori, Nakashima Tadashi
  • Journal Title: Laryngoscope 119 Pages: 203-210
  • Peer Reviewed
• [Journal Article] Histopathologic Investigations of the Unphonated Human Vocal Fold Mucosa. (2008)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi, NONAKA Satoshi,HARABUCHI Yasuaki
  • Journal Title: Acta Oto-Laryngologica 128 Pages: 694-701
  • Peer Reviewed
• [Journal Article] Cultured Stellate Cells in Human Vocal Fold Mucosa. (2008)
  • Author(s): SATO Kiminori, Yoshimi MIYAJIMA, Shinsuke Izumaru, NAKASHIMA Tadashi
  • Journal Title: The Journal of Laryngology & Otology 122 Pages: 1339-1342
  • Peer Reviewed
• [Journal Article] Irradiated Macula Flava in the Human Vocal Fold Mucosa (2008)
  • Author(s): SATO Kiminori, SHIROUZU Hidetaka, NAKASHIMA Tadashi
  • Journal Title: American Journal of Otolaryngology 29 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Effect of Irradiation on the Human Laryngeal Glands. (2008)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi
  • Journal Title: Annals of Otology, Rhinology & Laryngology 117 Pages: 734-739
  • Peer Reviewed
• [Journal Article] Irradiated Macula Flava in the Human Vocal Fold Mucosa (2008)
  • Author(s): Sato Kiminori, Shirouzu Hidetaka, Nakashima Tadashi
  • Journal Title: Am J Otolaryngol 122 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Cultured Stellate Cells in the Human Vocal Fold Mucosa (2008)
  • Author(s): SATO Kiminori, MIYAZIMA Yoshimi, IZUNARU Shinsuke, NAKASHIMA Tadashi
  • Journal Title: The Journal of Laryngology & Otology (印刷中)
  • Peer Reviewed
• [Journal Article] Histopathologic Investigations of the Unphonated Human VocaI Fold Mucosa (2008)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi, NONAKA Satoshi, HARABUCHI Yasuaki
  • Journal Title: Acta Oto-Laryngologica (印刷中)
  • Peer Reviewed
• [Presentation] Stellate Cells in the Human Child Vocal Fold (2008)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi
  • Organizer: The 129th Annual Meeting of the American Laryngological Association
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2008-05-01
• [Presentation] 小児声帯の黄斑と星型細胞 (2008)
  • Author(s): 佐藤公則, 中島 格
  • Organizer: 第20回日本喉頭科学会
  • Place of Presentation: 佐賀
  • Year and Date: 2008-03-13
• [Presentation] 人はなぜ一生発声できるのか .声帯粘膜の細胞と細胞外マトリックスの観点から (2007)
  • Author(s): 佐藤公則
  • Organizer: 第19回福岡県耳鼻咽喉科専門医会講演会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-27
• [Presentation] Cultured Stellate Cells in the Human Vocal Fold Mucosa. (2007)
  • Author(s): SATO Kiminori, MIYAJIMA Yoshimi IZUMARU Shinsuke, NAKASHIMA Tadashi
  • Organizer: The 128th Annual Meeting of the American Laryngological Association
  • Place of Presentation: San Diego, California
  • Year and Date: 2007-04-27
• [Presentation] Histopathologic Investigations of the Unphonated Human Vocal Fold Mucosa. (2007)
  • Author(s): SATO Kiminori, NAKASHIMA Tadashi, NONAKA Satoshi, HARABUCHI Yasuaki
  • Organizer: The 87th Annual Meeting of the American Broncho-Esophagological Association
  • Place of Presentation: San Diego, California
  • Year and Date: 2007-04-27
• [Presentation] Irradiated Macula Flava in the Human Vocal Fold Mucosa. (2007)
  • Author(s): SATO Kiminori,SHIROUZU Hidetaka, NAKASHIMA Tadashi
  • Organizer: The 128th Annual Meeting of the American Laryngological Association
  • Place of Presentation: San Diego, California
  • Year and Date: 2007-04-27
• [Presentation] Cultured Stellate Cells in the Human Vocal FoId Mucosast (2007)
  • Author(s): SATO Kiminori
  • Organizer: 第128回アメリカ喉頭科学会
  • Place of Presentation: サン・ディェゴ(アメリカ)
  • Year and Date: 2007-04-27
• [Presentation] Histopathologic Investigations of the Unphonated Human Vocal Fold Mucosa (2007)
  • Author(s): SATO Kiminori
  • Organizer: 第87回アメリカ気管食道科学会
  • Place of Presentation: サン・ディエゴ(アメリカ)
  • Year and Date: 2007-04-27
• [Book] 声帯の構造 新編 声の検査法 (2009)
  • Author(s): 佐藤公則
  • Publisher: 医歯薬出版、東京
• [Book] 声帯は楽器 新編 声の検査法 (2009)
  • Author(s): 佐藤公則
  • Total Pages: 129
  • Publisher: 医歯薬出版、東京
• [Book] 声帯の構造新編声の検査法 (2009)
  • Author(s): 佐藤公則
  • Publisher: 医歯薬出版、東京